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公开(公告)号：US07052876B1
公开(公告)日：2006-05-30
申请号：US09959085
申请日：2000-04-17
Applicant: Helene Margaret Finney , Alastair David Griffiths Lawson
CPC classification number: C12N15/1093 , C07K14/7051 , C07K14/70521 , C07K14/70535 , C07K14/70596 , C07K2319/02 , C12N15/10 , C12N15/102 , C12N15/66
Abstract: A method of generating novel nucleic acid molecules, by applying a combinatorial approach to the assembly of blocks of nucleic acid sequence, is described. By using restriction endonucleases having different recognition sites but which produce compatible cleavage products, a library of DNA molecules, of varying length and sequence, may be generated in a desired orientation.
Abstract translation: 描述了通过将组合方法应用于核酸序列嵌段的组装产生新的核酸分子的方法。 通过使用具有不同识别位点但产生相容的切割产物的限制性内切核酸酶，可以以期望的方向产生不同长度和序列的DNA分子文库。
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公开(公告)号：US10479824B2
公开(公告)日：2019-11-19
申请号：US12374213
申请日：2007-07-24
Applicant: Alastair David Griffiths Lawson , Paul Edward Stephens
Inventor： Alastair David Griffiths Lawson , Paul Edward Stephens
IPC: C07K16/00
Abstract: The present invention relates to single chain polypeptides comprising one or more immunoglobulin Fc domains. In particular the present invention relates to single-chain Fc polypeptides in which at least one functional Fc domain is formed within the polypeptide chain.
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公开(公告)号：US09394357B2
公开(公告)日：2016-07-19
申请号：US11910612
申请日：2006-04-04
Applicant: Alastair David Griffiths Lawson
Inventor： Alastair David Griffiths Lawson
IPC: C07K16/00
CPC classification number: C07K16/00 , C07K2317/56 , C07K2317/565 , C07K2317/92
Abstract: A method of obtaining at least one recombinant antibody with improved affinity for a selected antigen from a family of antibodies which bind the selected antigen comprising: a) obtaining a family of two or more antibodies which bind the same antigen in which the VH CDR3 amino acid sequence of each antibody in the family is the same length and greater than 60% identical at the amino acid level; b) re-pairing the VH region of an antibody obtained in step (a) with the VL region from a different antibody obtained in step (a) to produce a new recombinant antibody; and c) screening the recombinant antibody produced in step (b) and selecting said antibody if it has improved affinity for the selected antigen compared to any one of the antibodies obtained in step (a).
Abstract translation: 一种从结合所选抗原的抗体家族获得至少一种对所选抗原亲和力的重组抗体的方法，包括：a）获得结合相同抗原的两个或多个抗体的家族，其中所述抗体的VH CDR3氨基酸 家族中每种抗体的序列与氨基酸水平相同，长度大于60％; b）将步骤（a）中获得的抗体的VH区与来自步骤（a）中获得的不同抗体的VL区重新配对以产生新的重组抗体; 和c）筛选步骤（b）中产生的重组抗体，如果与步骤（a）中获得的任何一种抗体相比，对所选择的抗原具有改善的亲和力，则选择所述抗体。
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公开(公告)号：US08580265B2
公开(公告)日：2013-11-12
申请号：US13348456
申请日：2012-01-11
Applicant: Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
Inventor： Ralph Adams , Terence Seward Baker , Alastair David Griffiths Lawson
IPC: A61K39/395
CPC classification number: C07K16/244 , C07K2317/33 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。
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15.发明授权公开(公告)号：US08465744B2
公开(公告)日：2013-06-18
申请号：US12569700
申请日：2009-09-29
Applicant: Alastair David Griffiths Lawson , Andrew George Popplewell
IPC: A61K39/395
CPC classification number: C07K16/245 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1β, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
Abstract translation: 本发明涉及对IL-1β的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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Patent Agency Ranking
公开(公告)号：US20100158913A1
公开(公告)日：2010-06-24
申请号：US12569700
申请日：2009-09-29
Applicant: Alastair David Griffiths Lawson , Andrew George Popplewell
IPC: A61K39/395 , A61P37/00
CPC classification number: C07K16/245 , A61K47/60 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565
Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-1β, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.
Abstract translation: 本发明涉及对IL-1和bgr的抗原决定簇具有特异性的抗体分子;抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号：US20100093977A1
公开(公告)日：2010-04-15
申请号：US12443599
申请日：2007-09-28
CPC classification number: A61K49/0058 , A61K47/60 , A61K49/0041 , C07K16/00 , C07K16/3092 , C07K2317/52
Abstract: This invention relates to engineering of antibodies and more specifically provides altered antibodies of the IgG class to which one or more effector molecules are attached. The invention further relates to methods for the production of such conjugated antibodies.
Abstract translation: 本发明涉及抗体的工程，更具体地提供与一个或多个效应分子连接的IgG类别的改变的抗体。 本发明还涉及生产这种缀合抗体的方法。
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18.发明授权公开(公告)号：US09840556B2
公开(公告)日：2017-12-12
申请号：US11791498
申请日：2005-11-24
Applicant: Derek Thomas Brown , Hishani Kirby , Helene Margaret Finney , Alastair David Griffiths Lawson
Inventor： Derek Thomas Brown , Hishani Kirby , Helene Margaret Finney , Alastair David Griffiths Lawson
IPC: A61K39/395 , C07K16/28 , C07K16/24
CPC classification number: C07K16/241 , C07K2317/56 , C07K2317/76
Abstract: The present invention provides anti-TNFα antibodies which selectively inhibit TNFα signalling through the p55R. In particular the present invention provides anti-TNFα antibodies which selectively inhibit TNFα signalling through the p55R relative to the p75R.
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公开(公告)号：US08734798B2
公开(公告)日：2014-05-27
申请号：US12913145
申请日：2010-10-27
Applicant: Helene Margaret Finney , Terence Seward Baker , Alastair David Griffiths Lawson , Karen Margrete Miller , Marc Roger de Ryck , Christian Gilbert J Wolff
Inventor： Helene Margaret Finney , Terence Seward Baker , Alastair David Griffiths Lawson , Karen Margrete Miller , Marc Roger de Ryck , Christian Gilbert J Wolff
IPC: A61K39/395 , C12P21/08 , C07K16/00
CPC classification number: C07K16/28 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
Abstract: A Nav1.7 binding entity that after binding functionally modifies the activity of the ion channel, in particular an anti-Nav1.7 antibody or binding fragment thereof, pharmaceutical compositions comprising said antibodies, use of the antibodies and compositions comprising the same, in treatment, for example in the treatment/modulation of pain and processes for generating and preparing said antibodies.
Abstract translation: 结合后的Nav1.7结合实体功能性地修饰离子通道的活性，特别是抗Nav1.7抗体或其结合片段，包含所述抗体的药物组合物，使用抗体及其组合物在治疗中 ，例如在疼痛的治疗/调节中以及产生和制备所述抗体的方法。
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公开(公告)号：US08614295B2
公开(公告)日：2013-12-24
申请号：US12706993
申请日：2010-02-17
Applicant: Alastair David Griffiths Lawson , Andrew Malcolm Nesbitt , Andrew George Popplewell , Stevan Graham Shaw , Diana Shpektor , Yi Zhang
Inventor： Alastair David Griffiths Lawson , Andrew Malcolm Nesbitt , Andrew George Popplewell , Stevan Graham Shaw , Diana Shpektor , Yi Zhang
IPC: C07K16/00 , A61K39/395 , C07H21/04 , C12N5/16
CPC classification number: C07K16/2878 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/70578 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
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