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    Antibody that binds to cluster w-4 polypeptide of human small cell lung carcinoma cells
    5.
    发明授权
    Antibody that binds to cluster w-4 polypeptide of human small cell lung carcinoma cells 失效
    结合人小细胞肺癌细胞簇w-4多肽的抗体

    公开(公告)号：US5952471A

    公开(公告)日：1999-09-14

    申请号：US776694

    申请日：1997-02-03

    Applicant: Alastair David Griffiths Lawson

    Inventor： Alastair David Griffiths Lawson

    IPC: C07K14/705 ,  C07K16/30 ,  C07K16/00

    CPC classification number: C07K16/3023 ,  C07K14/705

    Abstract: Binding agents, such as antibodies, are described which selectively bind to the cluster-w4 polypeptide of human small cell lung carcinoma cells at a site located at and around valine-57 of the cluster-w4 polypeptide. The binding agents, either alone or linked to a reporter or effector molecule are of use in the diagnosis or treatment of human small cell lung carcinoma. Also described are peptides (A).sub.m -(T).sub.n -(T).sub.o -(K).sub.p -V-(A).sub.q -(G).sub.r -(G).sub.s -(A).sub.t -(L).sub.u having at least one of the core structures K-V-A, T-K-V, or V-A-G for use in the identification and/or preparation of binding agents according to the invention, as diagnostic reagents, or as immunostimulants.

    Abstract translation: PCT No.PCT / GB95 / 01795 Sec。 371日期1997年2月3日 102（e）1997年2月3日PCT PCT 1995年7月31日PCT公布。 出版物WO96 / 04312 日期1996年2月15日描述了结合剂，例如抗体，其选择性地结合位于群-W4多肽缬氨酸-57周围及其周围的人小细胞肺癌细胞的簇-W4多肽。 单独或与报告物或效应分子连接的结合剂可用于诊断或治疗人类小细胞肺癌。 还描述了具有在（A）m-（T）n-（T）o-（K）pV-（A）q-（G）r-（G）s-（A）t-（L） 用于鉴定和/或制备根据本发明的结合剂的核心结构KVA，TKV或VAG中的至少一种作为诊断试剂或作为免疫刺激剂。

    Antibody-Guided Fragment Growth
    7.
    发明申请
    Antibody-Guided Fragment Growth 审中-公开
    抗体指导片段生长

    公开(公告)号：US20110275857A1

    公开(公告)日：2011-11-10

    申请号：US13143747

    申请日：2010-01-12

    Applicant: Alastair David Griffiths Lawson

    Inventor： Alastair David Griffiths Lawson

    IPC: C07C233/00 ,  C07C39/00 ,  G01N33/68

    CPC classification number: C07K16/24 ,  C07K2299/00 ,  C07K2317/55 ,  C07K2317/76 ,  G01N33/6803 ,  G01N2500/04 ,  G16B15/00 ,  G16C99/00

    Abstract: The present invention relates to an improved method for drug discovery comprising using contact residue information derived from antibody-protein target interactions to help to direct the growth of small molecule fragments during the synthesis of a drug candidate. In particular, the present invention relates to the use of atomic structural information derived from anti-body-protein interactions to guide the growth of small molecular fragments during lead optimisation, thus generating small molecule compounds which can alter the biological activity of a target protein.

    Abstract translation: 本发明涉及用于药物发现的改进方法，其包括使用衍生自抗体 - 蛋白质靶相互作用的接触残基信息来帮助指导药物候选物合成期间小分子片段的生长。 特别地，本发明涉及在铅优化期间衍生自抗体 - 蛋白质相互作用的原子结构信息用于引导小分子片段的生长，从而产生可改变靶蛋白的生物活性的小分子化合物。

    Methods for producing antibodies
    8.
    发明授权
    Methods for producing antibodies 有权
    产生抗体的方法

    公开(公告)号：US07790414B2

    公开(公告)日：2010-09-07

    申请号：US10558572

    申请日：2004-05-24

    Applicant: Alastair David Griffiths Lawson ,  Daniel John Lightwood

    Inventor： Alastair David Griffiths Lawson ,  Daniel John Lightwood

    IPC: C12P21/08 ,  G01N33/577

    CPC classification number: C07K16/244 ,  C07K16/00

    Abstract: The invention relates to a method of obtaining an antibody with a desired function, the method comprising: a) bringing a population of B cells into contact with a capturing agent; b) separating the captured B cells from the uncaptured B cells; c) culturing a plurality of captured B cells wherein said B cells have not been sorted into single B cells immediately prior to culturing; d) screening a plurality of the cultured cells to identify cells capable of producing an antibody with the desired function; and e) obtaining the desired antibody therefrom.

    Abstract translation: 本发明涉及一种获得具有所需功能的抗体的方法，该方法包括：a）使B群体与捕获剂接触; b）将捕获的B细胞与未捕获的B细胞分离; c）培养多个捕获的B细胞，其中所述B细胞在培养之前立即未分选成单个B细胞; d）筛选多个培养细胞以鉴定能够产生具有所需功能的抗体的细胞; 和e）从其获得所需的抗体。

    Methods for obtaining antibodies
    9.
    发明申请
    Methods for obtaining antibodies 有权
    获得抗体的方法

    公开(公告)号：US20090275056A1

    公开(公告)日：2009-11-05

    申请号：US12387153

    申请日：2009-04-28

    Applicant: Alastair David Griffiths Lawson ,  Meryn Ruth Griffiths

    Inventor： Alastair David Griffiths Lawson ,  Meryn Ruth Griffiths

    IPC: G01N33/53

    CPC classification number: G01N33/582 ,  G01N33/56972

    Abstract: The invention is directed towards a method of enriching a population of cells in those cells that produce an antibody which recognises an antigen of interest. In particular, an untagged antigen is used in conjunction with a polyclonal antibody to isolate cells recognizing said antigen.

    Abstract translation: 本发明涉及一种富集产生识别感兴趣的抗原的抗体的那些细胞中的细胞群的方法。 特别地，未标记的抗原与多克隆抗体结合使用以分离识别所述抗原的细胞。

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