公开(公告)号：US5729014A

公开(公告)日：1998-03-17

申请号：US678742

申请日：1996-07-11

申请人： Alex Mordehai ,  Sidney E. Buttrill, Jr.

发明人： Alex Mordehai ,  Sidney E. Buttrill, Jr.

IPC分类号： H01J49/26 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/4295 ,  H01J49/424

摘要： A method of ion collection over a wide mass-to-charge range from continuous ion source into a quadrupole ion trap filled with a buffer gas directing an ion beam, from an external ion source to a radio frequency ion trap through a gating device for a predetermined period of accumulation time to allow the beam to enter the trap, trapping ions over a range of masses by applying a radio frequency voltage to the trap and changing an amplitude of the radio frequency voltage adiabatically to achieve a uniform trapping efficiency for ions over a predetermined mass range. The predetermined period of accumulation time may be divided into a plurality of segments, and the amplitude of the radio-frequency voltage is changing adiabatically within each segment.

摘要翻译： 一种在从连续离子源到充满缓冲气体的四极离子阱的宽质量 - 电荷范围内的离子收集方法，该缓冲气体从外部离子源到射频离子阱通过选通装置引导离子束 预定的累积时间，以允许光束进入陷阱，通过向陷阱施加射频电压而在一定范围的质量范围内捕获离子，并绝热地改变射频电压的振幅，以实现离子超过一定的捕获效率 预定质量范围。 累积时间的预定周期可以被划分成多个段，并且射频电压的幅度在每个段内都是绝热的。

公开(公告)号：US07166837B2

公开(公告)日：2007-01-23

申请号：US11069629

申请日：2005-02-28

申请人： Alex Mordehai

发明人： Alex Mordehai

IPC分类号： B01D59/44

CPC分类号： H01J49/4205 ,  H01J49/0063

摘要： A mass analyzer for isolating, fragmenting and scanning ions. The mass analyzer includes an ion trap having a first electrode, a second electrode adjacent to the first electrode, and a third electrode interposed between the first electrode and the second electrode, a first RF source electrically connected to the first electrode and second electrode and a second RF voltage source electrically connected to the third electrode. The second RF voltage source provides for a second electrical field for fragmenting ions and broadens the potential application of the fragmentation cut-off of the device allowing for analysis of peptides and other complex molecules. The mass analyzer may be used independently or in combination with a mass spectrometry system. A method of ion fragmentation and cut-off is also disclosed.

摘要翻译： 用于分离，分段和扫描离子的质量分析仪。 质量分析器包括具有第一电极，与第一电极相邻的第二电极和插在第一电极和第二电极之间的第三电极的离子阱，与第一电极和第二电极电连接的第一RF源和 电连接到第三电极的第二RF电压源。 第二RF电压源为第二电场提供了用于分离离子的能力，并扩大了器件的断裂截止点的潜在应用，从而可以分析肽和其他复杂分子。 质量分析仪可以独立使用或与质谱系统组合使用。 还公开了一种离子断裂和截止的方法。

公开(公告)号：US06914242B2

公开(公告)日：2005-07-05

申请号：US10314409

申请日：2002-12-06

申请人： Alex Mordehai

发明人： Alex Mordehai

IPC分类号： H01J49/42 ,  H01J49/26

CPC分类号： H01J49/063 ,  H01J49/004 ,  H01J49/061 ,  H01J49/40

摘要： Apparatus for delivering ions to a mass analyzer. The apparatus includes a time of flight ion guide, a pulsing device for receiving a continuous ion stream containing ions of different atomic mass and for delivering pulses of ions to the ion guide wherein ions in each of the pulses of ions exit the ion guide in ascending order of their atomic mass, and a gating device at the exit end of the ion guide for allowing ions of a predetermined atomic mass to pass to the mass analyzer.

摘要翻译： 用于将离子输送到质量分析器的装置。 所述装置包括飞行时间离子引导件，用于接收含有不同原子质量的离子的连续离子流的脉冲装置，用于将离子脉冲输送到离子导向器，其中每个离子脉冲中的离子以升序离开离子导向器 以及在离子导向件的出口端的选通装置，用于允许预定原子质量的离子通过质量分析器。

公开(公告)号：US06703610B2

公开(公告)日：2004-03-09

申请号：US10061465

申请日：2002-02-01

申请人： Alex Mordehai

发明人： Alex Mordehai

IPC分类号： H01J4000

CPC分类号： H01J49/04 ,  H01J49/067

摘要： The present invention relates to a method and apparatus for a mass spectrometer. The skimmer of the present invention has a surface to reduce the overall interaction and deposition of unwanted compounds. The surface of the skimmer may be formed from an inorganic conductive nitride or may be applied to a substrate as a coating. The invention also includes a method for reducing the interaction or deposition of compounds on a mass spectrometer skimmer by application or coating the skimmer with an inert conductive material.

摘要翻译： 本发明涉及质谱仪的方法和装置。 本发明的撇渣器具有减少不想要的化合物的整体相互作用和沉积的表面。 撇渣器的表面可以由无机导电氮化物形成，或者可以作为涂层施加到基板上。 本发明还包括通过用惰性导电材料施加或涂覆撇渣器来减少化合物在质谱分离器上的相互作用或沉积的方法。

公开(公告)号：US06624409B1

公开(公告)日：2003-09-23

申请号：US10208441

申请日：2002-07-30

申请人： Alex Mordehai ,  Jian Bai

发明人： Alex Mordehai ,  Jian Bai

IPC分类号： H01J4910

CPC分类号： H01J49/164 ,  G01N33/54393 ,  H01J49/0418

摘要： A substrate for matrix assisted laser desorption ionization mass spectrometry. The substrate has a layer of a nitride composition on the surface of the substrate. The nitride composition is a major amount by weight from the group of titanium nitride, zirconium nitride and hafnium nitride.

摘要翻译： 基质辅助激光解吸电离质谱法。 衬底在衬底的表面上具有氮化物组合物层。 氮化物组合物是来自氮化钛，氮化锆和氮化铪的重量的主要量。