公开(公告)号：US06797947B2

公开(公告)日：2004-09-28

申请号：US10664512

申请日：2003-09-16

Applicant: Charles W. Russ, IV ,  Steven M. Fischer

Inventor： Charles W. Russ, IV ,  Steven M. Fischer

IPC: H01J4910

CPC classification number: H01J49/0009 ,  H01J49/004

Abstract: An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is provided. A source of lock mass ions adjacent the ion optics creates lock mass ions within the ion optics. Lock mass ions mix with the analyte ions in the ion optics prior to mass analysis. The source of lock mass ions may include various means for ionizing lock mass molecules including but not limited to photoionization, field desorption-ionization, electron ionization, and thermal ionization means. An apparatus and method of mass calibrating a tandem mass spectrometer is also provided. The mass calibration apparatus includes a collision cell for fragmenting analyte ions and a source of lock mass ions adjacent said collision cell for creating lock mass ions in the collision cell.

Abstract translation: 提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。 与离子光学器件相邻的锁定质量离子源产生离子光学器件内的锁定质子离子。 在质量分析之前，将质子离子与离子光学中的分析物离子混合。 锁定质量离子的来源可以包括用于电离锁定质量分子的各种装置，包括但不限于光电离，场解吸电离，电子离子化和热电离装置。 还提供了质量校准串联质谱仪的装置和方法。 质量校准装置包括用于碎裂分析物离子的碰撞单元和邻近所述碰撞室的锁定质量离子源，用于在碰撞室中产生锁定质量离子。

公开(公告)号：US06734421B2

公开(公告)日：2004-05-11

申请号：US10092026

申请日：2002-03-06

Applicant: Armin Holle ,  Jochen Franzen

Inventor： Armin Holle ,  Jochen Franzen

IPC: H01J4910

CPC classification number: H01J49/164 ,  H01J49/40

Abstract: The invention concerns a time-of-flight mass spectrometer for the analysis of a large number of samples on a sample carrier using laser desorption and associated analytical procedures. The invention uses a special beam focusing system for the pulsed laser beam in a time-of-flight mass spectrometer to generate a firm pattern of focal points, inserts a pattern of samples on a sample carrier into the pattern of focal points, and focuses the ions generated in the laser focal points by an ion-optical imaging system onto one or more ion detectors in such a way that the samples in the focus pattern are measured simultaneously or quasi-simultaneously. The pattern of pulsed focal points can be created simultaneously through spatially splitting the beam, or by a temporal sequence of different deflections towards the firm locations of the pattern.

Abstract translation: 本发明涉及飞行时间质谱仪，用于使用激光解吸和相关分析程序分析样品载体上的大量样品。 本发明在飞行时间质谱仪中使用用于脉冲激光束的特殊光束聚焦系统来产生牢固的焦点图案，将样品载体上的样本图案插入焦点图案，并将焦点 在激光焦点中通过离子光学成像系统在一个或多个离子检测器上产生的离子，使得聚焦图案中的样品同时或准同时测量。 脉冲焦点的图案可以通过空间分割光束或通过不同偏转的时间序列朝着图案的固定位置同时产生。

公开(公告)号：US06630664B1

公开(公告)日：2003-10-07

申请号：US09596307

申请日：2000-06-14

Applicant: Jack A. Syage ,  Karl A. Hanold ,  Matthew D. Evans ,  Yong Liu

Inventor： Jack A. Syage ,  Karl A. Hanold ,  Matthew D. Evans ,  Yong Liu

IPC: H01J4910

CPC classification number: H01J49/162 ,  H01J49/107 ,  H01J49/165

Abstract: A monitor that can detect a trace molecule that is ionized at approximately one atmosphere. The molecule is ionized with a photoionizer and detected by a detector. The monitor may include a number of techniques to introduce a sample into the photoionizer at approximately one atmosphere. One technique includes creating an electrically charged spray that is directed into the ionizer. The photoionizer may include a plurality of light sources that each ionize the sample with a different radiation energy.

Abstract translation: 可以检测大约一个大气电离的痕量分子的监测器。 分子用光电离器离子化，并由检测器检测。 监测器可以包括在大约一个大气压下将样品引入光离子化器的许多技术。 一种技术包括产生引导到电离器中的带电喷雾。 光离子化器可以包括多个光源，每个光源以不同的辐射能量离子化样品。

公开(公告)号：US06236054B1

公开(公告)日：2001-05-22

申请号：US09269801

申请日：1999-12-15

Applicant: Arpád Barna ,  Dezsö Szigethy

Inventor： Arpád Barna ,  Dezsö Szigethy

IPC: H01J4910

CPC classification number: H01J27/04 ,  H01J2237/08 ,  H01J2237/3114

Abstract: An ion source for generating ions of a gas or vapor, especially for thinning solid state samples, includes a housing, an arrangement for introducing the gas or vapor into the housing and an anode positioned within the housing. The anode has a rotationally symmetrical cavity which is open at both sides along the axis of the source. First and second electrooptical mirrors are disposed along the source axis and define therebetween a space in which the anode is positioned The mirrors produce an electrostatic field to cause electrons to oscillate between them. At least one of the mirrors is apertured for exit therethrough of a fraction of ions generated in the space. An electron generating arrangement is disposed at one side of the cavity externally of the space between the mirrors and further, an arrangement causes the electrons to move into the cavity.

Abstract translation: 用于产生气体或蒸气的离子的离子源，特别是用于稀释固态样品的离子源包括壳体，用于将气体或蒸气引入壳体中的装置和位于壳体内的阳极。 阳极具有旋转对称的空腔，其沿着源的轴线在两侧敞开。 第一和第二电光镜沿着源轴设置并且在其间限定放置阳极的空间。反射镜产生静电场以使电子在它们之间振荡。 至少一个反射镜是有孔的，用于从空间中产生的一部分离子穿过其中。 电子产生装置设置在反射镜之间的空间外部的空腔的一侧，并且进一步地，电子移动到空腔中。

公开(公告)号：US06818909B2

公开(公告)日：2004-11-16

申请号：US10703165

申请日：2003-11-07

Applicant: Adrian Murrell ,  Peter Michael Banks ,  Andrew Allen ,  Neil L. Clarke ,  Matthew Peter Dobson

Inventor： Adrian Murrell ,  Peter Michael Banks ,  Andrew Allen ,  Neil L. Clarke ,  Matthew Peter Dobson

IPC: H01J4910

CPC classification number: H01J37/08 ,  H01J37/3171

Abstract: The invention relates to an ion source for an ion implanter in which source material for providing desired ions is provided in the form of a plate or liner which can be fitted into the reactant chamber of the ion source.

Abstract translation: 本发明涉及一种用于离子注入机的离子源，其中用于提供期望离子的源材料以可装配到离子源的反应物室中的板或衬里的形式提供。

公开(公告)号：US06812648B2

公开(公告)日：2004-11-02

申请号：US10419990

申请日：2003-04-22

Applicant: Henry A. Luten ,  Vijayen S. Veerasamy ,  Maximo Frati ,  Denis Shaw

Inventor： Henry A. Luten ,  Vijayen S. Veerasamy ,  Maximo Frati ,  Denis Shaw

IPC: H01J4910

CPC classification number: H01J27/143

Abstract: A method and/or system for cleaning an ion source is/are provided. In certain embodiments of this invention, both the anode and cathode of the ion source are negatively biased during at least part of a cleaning mode. Ions generated are directed toward the anode and/or cathode in order to remove undesirable build-ups from the same during cleaning.

Abstract translation: 提供了用于清洁离子源的方法和/或系统。 在本发明的某些实施例中，离子源的阳极和阴极在清洁模式的至少部分期间是负偏压的。 生成的离子指向阳极和/或阴极，以便在清洁期间从其中除去不期望的堆积物。

公开(公告)号：US06462336B1

公开(公告)日：2002-10-08

申请号：US09214359

申请日：1999-09-16

Applicant: Stevan Bajic

Inventor： Stevan Bajic

IPC: H01J4910

CPC classification number: H01J49/067 ,  H01J49/04

Abstract: An ion source for a mass spectrometer operating at a low pressure has an atmospheric pressure sample ioniser which provides a sample flow containing desired sample ions. These ions are usually entrained with undesired gas and droplets. An interface chamber is held by a vacuum pump at a pressure between atmospheric and the operating pressure of the mass spectrometer. Sample ions with entrained gas are collected through an entrance orifice forming a stream of gas into the interface chamber. Sample ions exit the interface chamber through an exit orifice to the mass spectrometer. The interface chamber disrupts the stream of gas entering the interface chamber to provide a dead region having no net gas flow direction and the exit orifice is located in this dead region. The exit orifice should have no line of sight path to the entrance orifice or should be at least 30° off the flow axis of the stream entering the interface chamber through the entrance orifice. A flow disrupting pin is located in the interface chamber to disrupt the flow of the stream of gas entering through the entrance orifice.

Abstract translation: 用于在低压下操作的质谱仪的离子源具有提供含有所需样品离子的样品流的大气压样品离子发生器。 这些离子通常携带不想要的气体和液滴。 界面室由真空泵在大气压和质谱仪的工作压力之间的压力下保持。 具有夹带气体的样品离子通过形成气流的入口孔收集到界面室中。 样品离子通过出口孔离开界面室至质谱仪。 界面室破坏进入界面室的气体流，以提供没有净气体流动方向的死区，并且出口孔位于该死区。 出口孔应没有到入口孔的视线路线，或者应该离开通过入口孔进入界面室的流的流动轴线至少30°。 流动破坏销位于界面室中，以破坏通过入口孔进入的气流的流动。

公开(公告)号：US06437327B2

公开(公告)日：2002-08-20

申请号：US09859508

申请日：2001-05-18

Applicant: Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

Inventor： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

IPC: H01J4910

CPC classification number: H01J49/165 ,  G01N30/7266 ,  H01J49/168

Abstract: A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to or at an angle with respect to a center axis of the aperture, and a tip of the needle is disposed facing to an electrode having the aperture.

Abstract translation: 一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔 设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。 由喷雾器引起的喷雾方向几乎与孔的中心轴垂直或成一定角度，并且针的尖端面向具有孔的电极。

公开(公告)号：US06432311B1

公开(公告)日：2002-08-13

申请号：US09745779

申请日：2000-12-21

Applicant: James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: H01J4910

Abstract: An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may -be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US06245227B1

公开(公告)日：2001-06-12

申请号：US09156037

申请日：1998-09-17

Applicant: James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: H01J4910

CPC classification number: G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

Abstract translation: 公开了电喷雾装置，液相色谱装置和电喷雾 - 液相色谱系统。 电喷雾装置包括：基材，其限定在喷射表面上的入口孔与喷射表面上的出口孔之间的通道;由从出射孔周围的喷射表面凹陷的部分限定的喷嘴;以及用于施加电 对基板进行优化和产生电喷雾的潜力; 和可选的附加电极以进一步改变电喷雾。 所述液相色谱装置包括分隔衬底，所述分离衬底限定入口孔和贮存器之间的引入通道以及所述储存器和出口孔之间的分离通道，所述分离通道具有垂直于所述流体流动的分离柱; 覆盖基板，其结合到分离基板以封闭储存器和与盖基板相邻的分离通道; 和可选地用于向流体施加电势的电极。 液相色谱装置的出口可以与电喷雾装置的入口孔均匀地接合，以形成一个集成的单一系统。 多个系统的阵列可以制造在单个单片芯片中，用于快速顺序流体处理和产生用于后续分析的电喷雾，例如通过将电喷雾装置的出口孔定位在质谱仪的采样孔附近。