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公开(公告)号：US20060014727A1
公开(公告)日：2006-01-19
申请号：US11158291
申请日：2005-06-20
申请人： Aly Karsan , Michel Roberge , Raymond Andersen , Ingrid Pollet
发明人： Aly Karsan , Michel Roberge , Raymond Andersen , Ingrid Pollet
CPC分类号： G01N33/5064 , A61K31/575 , A61K38/1825 , A61K38/1866 , C07J31/00 , C07J31/006 , G01N33/5008 , G01N33/5017 , G01N33/5026 , A61K2300/00
摘要： The invention provides sterol sulphate compounds and compositions that are capable of promoting angiogenesis. The invention also provides methods and uses for these compounds.
摘要翻译： 本发明提供能够促进血管生成的硫酸固醇化合物和组合物。 本发明还提供了这些化合物的方法和用途。
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公开(公告)号：US20130217674A1
公开(公告)日：2013-08-22
申请号：US13817106
申请日：2011-08-22
IPC分类号： C07C43/23 , C07C49/747 , C07C215/64 , C07C69/734 , C07C251/44 , C07D223/32 , C07C41/18 , C07C45/30 , C07C45/65 , C07C213/02 , C07C67/08 , C07C249/08 , C07C39/17 , C07C37/50 , C07C49/753
CPC分类号： C07C43/23 , A61K31/045 , C07B2200/07 , C07C37/50 , C07C39/17 , C07C41/18 , C07C45/30 , C07C45/65 , C07C49/747 , C07C49/753 , C07C67/08 , C07C69/65 , C07C69/734 , C07C213/02 , C07C215/44 , C07C215/64 , C07C249/08 , C07C251/44 , C07C2603/40 , C07D223/32
摘要： Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed.
摘要翻译： 结构（I）的化合物：包括立体异构体及其药学上可接受的盐，其中R1，R2和A如本文所定义。 这些化合物具有增强的水溶性并且具有作为SHIP1调节剂的活性，因此可用于治疗将受益于SHIP1调节的各种疾病，病症或病症中的任何一种。 还公开了用于制备结构（I）化合物的对映选择性方法，包含结构（I）化合物与药学上可接受的载体或稀释剂的组合物的组合物以及通过将这些化合物施用于有需要的动物的SHIP1调节方法。
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13.发明申请Small-Molecule Hepatitis C Virus (HCV) NS3/4A Serine Protease Inhibitors 审中-公开小分子丙型肝炎病毒（HCV）NS3 / 4A丝氨酸蛋白酶抑制剂公开(公告)号：US20100168225A1
公开(公告)日：2010-07-01
申请号：US12594790
申请日：2008-04-18
申请人： Francois Jean , Raymond Andersen
发明人： Francois Jean , Raymond Andersen
IPC分类号： A61K31/37 , C07D311/20 , A61P31/14
CPC分类号： C07D311/16
摘要： Compounds of Formula 5 and prodrug compounds of Formula 5 wherein G1 is H or OH; G2 is H, R′, or CO2R′; G3, G4 and G5, are each independently selected from the group consisting of: H, R′, OH, OR′, F, Cl, Br, I, NH2, NHR′,NR′2, CN, SH, SR′, SO3H, SO3R′, SO2R′, OSO3R′, and NO2; and R′ is a one to four carbon alkyl group are provided. Uses of these compounds and methods of medical treatment involving these compounds for the treatment of hepatitis C are also provided.
摘要翻译： 式5的化合物和式5的前药化合物，其中G 1是H或OH; G2是H，R'或CO 2 R'; G3，G4和G5各自独立地选自：H，R'，OH，OR'，F，Cl，Br，I，NH 2，NHR'，NR'2，CN，SH，SR' SO3H，SO3R'，SO2R'，OSO3R'和NO2; 并且提供R'为1-4个碳烷基。 还提供了这些化合物的使用和涉及这些化合物用于治疗丙型肝炎的医学治疗方法。
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14.发明申请Motorized RF wireless controlled tubing storage device for home therapeutic oxygen use patients 审中-公开用于家庭治疗氧用患者的电动RF无线控制管道储存装置公开(公告)号：US20060186254A1
公开(公告)日：2006-08-24
申请号：US10906530
申请日：2005-02-23
IPC分类号： B65H75/38
CPC分类号： B65H75/4486 , A61M2209/08 , B65H2551/13
摘要： Therapeutic oxygen tubing length is controlled with this device, using a wireless RF remote, utilizing a low voltage motor, a torque activated clutch for rewind/free-wheeling unwind operation and has a simple spool/tubing change out process without the need of tools.
摘要翻译： 使用无线射频遥控器，利用低压电机，用于倒带/续轮退绕操作的转矩激活离合器来控制治疗氧气管长度，并且在不需要工具的情况下具有简单的阀芯/管道更换过程。
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公开(公告)号：US08431541B2
公开(公告)日：2013-04-30
申请号：US12738273
申请日：2008-10-16
CPC分类号： C07H15/26 , A23G4/12 , A23L33/105 , A23V2002/00 , A23V2200/312 , A23V2200/316 , A23V2250/2116
摘要： Particular naturally occurring glycosylated acyl-flavonols are now shown to be effective mammalian α-amylase inhibitors. Such compounds can be obtained from plants of the genus Crocosmia and the compounds are useful in controlling starch digestion such as for management of glycemia in pre-diabetic or diabetic subjects, for management of obesity or for inhibiting oral caries or plaque formation.
摘要翻译： 特别是天然存在的糖基化酰基黄酮醇现在被证明是有效的哺乳动物α-淀粉酶抑制剂。 这些化合物可以从Crocosmia属的植物中获得，并且该化合物可用于控制淀粉消化，例如用于治疗糖尿病前期或糖尿病患者的血糖，用于管理肥胖症或抑制口腔龋齿或斑块形成。
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16.发明申请公开(公告)号：US20110189107A1
公开(公告)日：2011-08-04
申请号：US12738273
申请日：2008-10-16
CPC分类号： C07H15/26 , A23G4/12 , A23L33/105 , A23V2002/00 , A23V2200/312 , A23V2200/316 , A23V2250/2116
摘要： Particular naturally occurring glycosylated acyl-flavonols, e.g. montbretin A (of the formula below wherein R1, R2, R3, R5, R5′, and R7 is OH each, X is β-D-glucopyranosyl), are now shown to be effective mammalian α-amylase inhibitors Such compounds can be obtained from plants of the genus Crocosmia The compounds and their analogs of the formula below are useful in controlling starch digestion such as for management of glycemia in pre-diabetic or diabetic subjects, for management of obesity or for inhibiting oral caries or plaque formation R1, R2, R3, R5, R5′ and R7 are independently H, OH or OR, wherein R is C1-C6 alkyl, X is H, OH, or glucopyranosyl moiety each
摘要翻译： 特别是天然存在的糖基化酰基黄酮醇，例如 现在显示，montbretin A（其中R 1，R 2，R 3，R 5，R 5'和R 7是OH，各自为X，R'，D-吡喃葡萄糖基），这些化合物可以是有效的哺乳动物α-淀粉酶抑制剂 从Crocosmia植物获得的化合物及其类似物可用于控制淀粉消化，如用于管理糖尿病前期或糖尿病患者的血糖，用于管理肥胖或抑制口腔龋齿或斑块形成R1， R2，R3，R5，R5'和R7独立地为H，OH或OR，其中R为C1-C6烷基，X为H，OH或吡喃葡糖基部分
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17.发明申请公开(公告)号：US20100280004A1
公开(公告)日：2010-11-04
申请号：US12667284
申请日：2008-07-03
申请人： Raymond Andersen , Robert Keyzers , Christopher Anthony Gray , David Y. Thomas , John W. Hanrahan , Graeme W. Carlile
发明人： Raymond Andersen , Robert Keyzers , Christopher Anthony Gray , David Y. Thomas , John W. Hanrahan , Graeme W. Carlile
IPC分类号： A61K31/55 , C07D487/04 , A61P5/00
CPC分类号： A61K31/55 , C07D487/14
摘要： This invention provides compounds of Formula I. The compounds are correctors of ΔF508 CFTR trafficking. Also provided are uses of compounds of Formula I for treatment, as well as methods of treatment, of cystic fibrosis.
摘要翻译： 本发明提供了式I化合物。化合物是“Fgr”F508 CFTR转运的校正剂。 还提供了式I化合物用于治疗的用途以及治疗囊性纤维化的方法。
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公开(公告)号：US07579323B1
公开(公告)日：2009-08-25
申请号：US09581511
申请日：1998-12-13
申请人： Raymond Andersen , Edward Piers , James Nieman , John Coleman , Michel Roberge
发明人： Raymond Andersen , Edward Piers , James Nieman , John Coleman , Michel Roberge
IPC分类号： C07K5/06
CPC分类号： C07K5/0205 , A61K38/00 , C07C271/22
摘要： This invention provides analogs of hemiasterlin, methods of synthesis of the analogs and use of the analogs as cytotoxic and anti-mitotic agents.
摘要翻译： 本发明提供半精球蛋白类似物，合成类似物的方法和类似物作为细胞毒性和抗有丝分裂剂的用途。
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公开(公告)号：US20060252705A1
公开(公告)日：2006-11-09
申请号：US11477730
申请日：2006-06-29
IPC分类号： A61K31/704 , G01N33/53 , C12P19/02 , C12P33/00
CPC分类号： A01K67/027 , A01K2227/105 , A01K2267/0318 , G01N33/6896 , G01N33/92 , G01N2400/02 , G01N2800/28 , Y10T436/143333
摘要： The invention relates to the identification of sterol glucoside toxins, and provides methods for detecting and detoxifying the compounds, as well as therapeutic methods for treating subjects exposed to such toxins. In alternative embodiments, the toxins may for example include beta-sitostrol-beta-D-glucoside (5-cholesten-24b-ethyl-3b-ol-D-glucoside) or cholesterol glucoside (5-cholesten-3b-ol-3b-D-glucoside).
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公开(公告)号：US06291447B1
公开(公告)日：2001-09-18
申请号：US09258991
申请日：1999-02-26
申请人： Raymond Andersen , Michel Roberge , Jasbinder Sanghera , Daniel Leung , Edward Piers , Roberto GS Berlinck , Robert Britton
发明人： Raymond Andersen , Michel Roberge , Jasbinder Sanghera , Daniel Leung , Edward Piers , Roberto GS Berlinck , Robert Britton
IPC分类号： C07D48714
CPC分类号： C07D487/14 , C07H9/06 , C07H19/044 , C07H19/23
摘要： Novel granulatimide compounds and pharmaceutical formulations thereof are provided. Compounds of this invention have the general formula: wherein are independently R or Z as defined below, or in combination F and F′ is Ar1 as defined below; Ar1 is a monocyclic, bicyclic or tricyclic, fully or partially aromatic system containing five or six membered carbocyclic or, oxygen, nitrogen or sulphur containing heterocyclic rings, optionally substituted with R or Z; W is selected from the group consisting of formula (i); (ii) or (iii), wherein the structures are as follows:
摘要翻译： 提供了新的颗粒酰亚胺化合物及其药物制剂。 本发明的化合物具有以下通式：其中独立地为如下定义的R或Z，或者组合F和F'如下定义的Ar 1; Ar 1是单环，双环或三环，全部或部分芳族体系，其含有五或六个 任选被R或Z取代的W，W选自由式（ⅰ）组成的组; （ii）或（iii），其中结构如下：
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