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公开(公告)号：US20240050430A1
公开(公告)日：2024-02-15
申请号：US18213464
申请日：2023-06-23
Applicant: Amgen Inc.
Inventor： John Gordon ALLEN , Jennifer Rebecca ALLEN , Ana Elena MINATTI , Qiufen XUE , Ryan Paul WURZ , Christopher M. TEGLEY , Alexander J. PICKRELL , Thomas T. NGUYEN , Vu Van MA , Patricia LOPEZ , Longbin LIU , David John KOPECKY , Michael J. FROHN , Ning CHEN , Jian Jeffrey CHEN , Aaron C. SIEGMUND , Albert AMEGADZIE , Nuria A. TAMAYO , Shon BOOKER , Clifford GOODMAN , Mary WALTON , Nobuko NISHIMURA , Youngsook SHIN , Jonathan D. LOW , Victor J. CEE , Anthony B. REED , Hui-Ling WANG , Brian Alan LANMAN
IPC: A61K31/517 , A61P35/00 , A61K31/4985 , A61K39/395 , C07D403/04 , C07D471/04
CPC classification number: A61K31/517 , A61P35/00 , C07D471/04 , A61K39/39558 , C07D403/04 , A61K31/4985
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20220002298A1
公开(公告)日：2022-01-06
申请号：US17482230
申请日：2021-09-22
Applicant: Amgen Inc.
Inventor： Jian CHEN , Nuria A. TAMAYO , Longbin LIU , Hui-Ling WANG , Brian Alan LANMAN , Ryan Paul WURZ , Youngsook SHIN , Victor J. CEE
IPC: C07D471/04 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20210009577A1
公开(公告)日：2021-01-14
申请号：US17031607
申请日：2020-09-24
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN
IPC: C07D417/04 , A61K38/07 , C07D487/08 , C07D417/12 , C07D513/04 , C07D487/10 , C07D487/04 , C07D471/04 , C07D401/04 , C07D239/80 , C07D401/14 , C07D237/34 , C07D403/04 , A61K31/496 , A61K31/416 , A61K31/55 , A61K31/454 , A61K31/517 , A61K31/519 , A61K31/502 , A61K31/5025 , A61P35/00 , A61K31/7068 , C07D275/04 , C07D475/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20180334454A1
公开(公告)日：2018-11-22
申请号：US15984855
申请日：2018-05-21
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , David John KOPECKY , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Nobuko NISHIMURA , Youngsook SHIN , Nuria A. TAMAYO , John Gordon ALLEN , Jennifer Rebecca ALLEN
IPC: C07D417/04 , C07D275/04 , C07D487/08 , C07D417/12 , C07D513/04 , C07D487/10 , C07D487/04 , C07D471/04 , C07D401/04 , C07D239/80 , C07D401/14 , C07D237/34 , C07D403/04 , A61K31/496 , A61K31/416 , A61K31/55 , A61K31/454 , A61K31/517 , A61K31/519 , A61K31/502 , A61K31/5025 , A61P35/00 , A61K31/7068 , A61K38/07
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20140066430A1
公开(公告)日：2014-03-06
申请号：US14045715
申请日：2013-10-03
Applicant: Amgen Inc.
Inventor： Victor J. CEE , Holly L. DEAK , Bingfan DU , Stephanie D. GEUNS-MEYER , Brian L. HODOUS , Hanh Nho NGUYEN , Philip R. Olivieri , Vinod F. Patel , Karina ROMERO , Laurie Schenkel
IPC: C07D401/14 , C07D491/048 , C07D417/14 , C07D409/14 , C07D471/04 , C07D495/04
CPC classification number: C07D401/14 , C07D237/30 , C07D239/42 , C07D401/04 , C07D409/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04 , C07D497/04
Abstract: The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating Aurora kinase protein activity, thereby influencing various disease states and conditions related to the activities of Aurora kinase proteins. For example, the compounds are capable of influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, processes of preparing compounds of the invention, synthetic intermediates and methods of treatment of conditions related to the activity of Aurora kinase.
Abstract translation: 本发明涉及具有通式I的化合物，其中A1，A2，C1，C2，D，L1，L2，Z和R3，R4，R6，R7和R8如本文所定义，其能够调节极光激酶蛋白 活动，从而影响与Aurora激酶蛋白活性相关的各种疾病状态和病症。 例如，化合物能够影响细胞周期和细胞增殖的过程，以治疗癌症和与癌症有关的疾病。 本发明还包括药物组合物，制备本发明化合物的方法，合成中间体和治疗与Aurora激酶活性有关的病症的方法。
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Patent Agency Ranking
公开(公告)号：US20240287068A1
公开(公告)日：2024-08-29
申请号：US18640641
申请日：2024-04-19
Applicant: Amgen Inc.
Inventor： Brian Alan LANMAN , Shon BOOKER , Clifford GOODMAN , Anthony B. REED , Jonathan D. LOW , Hui-Ling WANG , Ning CHEN , Ana Elena MINATTI , Ryan WURZ , Victor J. CEE
IPC: C07D471/04 , A61K31/519 , A61K31/7068 , A61K38/07 , A61P35/00
CPC classification number: C07D471/04 , A61K31/519 , A61P35/00 , A61K31/7068 , A61K38/07 , A61K2300/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20240190862A1
公开(公告)日：2024-06-13
申请号：US17769631
申请日：2020-10-22
Applicant: AMGEN INC.
Inventor： Hui-Ling WANG , Victor J. CEE
IPC: C07D471/04 , A61K45/06 , C07D519/00
CPC classification number: C07D471/04 , A61K45/06 , C07D519/00
Abstract: Provided herein are KRAS G12C and KRAS G12D inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20220175782A1
公开(公告)日：2022-06-09
申请号：US17579359
申请日：2022-01-19
Applicant: AMGEN INC.
Inventor： John Gordon ALLEN , Brian Alan LANMAN , Jian CHEN , Anthony B. REED , Victor J. CEE , Longbin LIU , Patricia LOPEZ , Ryan Paul WURZ , Thomas T. NGUYEN , Shon BOOKER , Jennifer Rebecca ALLEN , Margaret CHU-MOYER , Albert AMEGADZIE , Ning CHEN , Clifford GOODMAN , Jonathan D. LOW , Vu Van MA , Ana Elena MINATTI , Nobuko NISHIMURA , Alexander J. PICKRELL , Hui-Ling WANG , Youngsook SHIN , Aaron C. SIEGMUND , Kevin C. YANG , Nuria A. TAMAYO , Mary WALTON , Qiufen XUE
IPC: A61K31/519 , A61K31/551 , A61K39/395 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20220168280A1
公开(公告)日：2022-06-02
申请号：US17589163
申请日：2022-01-31
Applicant: AMGEN INC.
Inventor： Brian Alan LANMAN , Victor J. CEE , Alexander J. PICKRELL , Anthony B. REED , Kevin C. YANG , David John KOPECKY , Hui-Ling WANG , Patricia LOPEZ , Kate ASHTON , Shon BOOKER , Christopher M. TEGLEY
IPC: A61K31/428 , A61K31/496 , A61K31/519 , A61P35/00 , A61K31/5025 , A61K31/502 , A61K31/517 , C07D275/04 , C07D471/08 , C07D403/04 , C07D401/04 , C07D513/04 , C07D487/04 , C07D417/04 , C07D239/80 , C07D487/10 , C07D471/04
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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公开(公告)号：US20200165231A1
公开(公告)日：2020-05-28
申请号：US16687546
申请日：2019-11-18
Applicant: Amgen Inc.
Inventor： Youngsook SHIN , Victor J. CEE , Christopher M. TEGLEY , Brian Alan LANMAN , Ryan Paul WURZ , Kevin C. YANG , Vu Van MA , Daniel ERLANSON , Joon Won JEONG , Raymond V. FUCINI , Jeffrey IWIG
IPC: C07D403/14 , C07D487/04 , C07D403/12 , C07D498/04 , C07D471/04 , C07D417/14 , C07D401/14 , A61P35/00
Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
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