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    Monoclonal antibody
    12.
    发明申请
    Monoclonal antibody 有权
    单克隆抗体

    公开(公告)号：US20090017041A1

    公开(公告)日：2009-01-15

    申请号：US12213007

    申请日：2008-06-12

    申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

    发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

    IPC分类号： A61K39/395 ,  C07K16/18 ,  A61K39/00 ,  G01N33/566 ,  C12N5/16 ,  C07H21/04

    CPC分类号： G01N33/6896 ,  A61K39/0007 ,  A61K39/3955 ,  A61K47/6911 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76 ,  G01N2333/4709 ,  G01N2800/2821

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉状蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供新的方法和组合物，其包含具有特异性识别和结合来自β-淀粉样蛋白范围的特异性表位的能力的高度特异性和高效抗体。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

    Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
    14.
    发明授权
    Polynucleotides encoding an anti-beta-amyloid monoclonal antibody 有权
    编码抗β-淀粉样蛋白单克隆抗体的多核苷酸

    公开(公告)号：US09146244B2

    公开(公告)日：2015-09-29

    申请号：US13272603

    申请日：2011-10-13

    申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs

    发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs

    IPC分类号： C07H21/04 ,  C07K16/18 ,  G01N33/68 ,  A61K39/395 ,  A61K39/00 ,  A61K47/48

    CPC分类号： G01N33/6896 ,  A61K39/0007 ,  A61K39/3955 ,  A61K47/6911 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/76 ,  G01N2333/4709 ,  G01N2800/2821

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供包含高度特异性和高效抗体的方法和组合物，其具有特异性识别并结合来自一系列淀粉样蛋白质的特定表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白斑形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

    Methods of treating and monitoring disease with antibodies
    15.
    发明授权
    Methods of treating and monitoring disease with antibodies 有权
    用抗体治疗和监测疾病的方法

    公开(公告)号：US08124353B2

    公开(公告)日：2012-02-28

    申请号：US12311505

    申请日：2007-10-02

    申请人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

    发明人： Andrea Pfeifer ,  Maria Pihlgren ,  Andreas Muhs ,  Ryan Watts

    IPC分类号： G01N33/53

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  G01N33/6896

    摘要： The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of j3-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

    摘要翻译： 本发明涉及用于治疗和诊断用途的方法和组合物，所述方法和组合物用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白质引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样蛋白相关的一组障碍和异常，例如 阿尔茨海默氏病。 本发明提供包含高度特异性和高效抗体的新型方法和组合物，其具有特异性识别并结合来自一系列j3-淀粉样蛋白质的特异性表位的能力。 通过本发明的教导实现的抗体特别可用于治疗由淀粉样蛋白或淀粉样蛋白样蛋白引起或与之相关的疾病和病症，包括淀粉样变性，与淀粉样斑块形成相关的一组疾病和病症，包括继发性淀粉样变性 和年龄相关的淀粉样变性病，包括但不限于神经障碍如阿尔茨海默病（AD）。

    Method for therapeutic use
    17.
    发明申请
    Method for therapeutic use 审中-公开
    治疗用途的方法

    公开(公告)号：US20100285108A1

    公开(公告)日：2010-11-11

    申请号：US12661628

    申请日：2010-03-18

    申请人： Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren

    发明人： Andrea Pfeifer ,  Andreas Muhs ,  Maria Pihlgren

    IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K39/385 ,  A61P25/28 ,  A61P37/04 ,  A61P31/18 ,  A61P25/00 ,  A61P25/16

    CPC分类号： C07K14/4711 ,  A61K39/0007 ,  A61K2039/55555 ,  A61K2039/6018

    摘要： The present invention is related to methods for the therapeutic use in the treatment of diseases and disorders where T-helper independent antibody responses are beneficial. In particular, the present invention relates to a method wherein these diseases and disorders above are treated in immunocompromised or autoimmune diseased animals or humans. Even more particular the present invention relates to the treatment of Alzheimer's disease in immunocompromised or autoimmune diseased animals or humans or where inflammatory reactions need to be specifically avoided.

    摘要翻译： 本发明涉及治疗用于治疗T辅助者独立抗体应答有益的疾病和病症的方法。 特别地，本发明涉及一种方法，其中在免疫受损或自身免疫疾病的动物或人中治疗上述这些疾病和病症。 更具体地，本发明涉及在免疫受损或自身免疫疾病的动物或人中治疗阿尔茨海默病，或者需要特别避免炎症反应。