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    CRYSTALLINE FORMS AND POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS SUCCINATE SALTS
    15.
    发明申请
    CRYSTALLINE FORMS AND POLYMORPHS OF N-(3-(DIMETHYLAMINO)PROPYL)-4-(4-(3-FLUORO-4-METHOXYPHENYL) PYRIMIDIN-2-YLAMINO) BENZENESULFONAMIDE AS SUCCINATE SALTS 审中-公开
    N-（3-（二甲基氨基）丙基）-4-（4-（3-氟-4-甲氧基苯基）嘧啶-2-基氨基）苯甲酰胺作为磺酸盐的结晶形式和聚合物

    公开(公告)号：US20080262008A1

    公开(公告)日：2008-10-23

    申请号：US12105443

    申请日：2008-04-18

    申请人： Mahmoud Mirmehrabi ,  Sreenivasulu Megati ,  Abdolsamad Tadayon ,  Subodh Deshmukh

    发明人： Mahmoud Mirmehrabi ,  Sreenivasulu Megati ,  Abdolsamad Tadayon ,  Subodh Deshmukh

    IPC分类号： A61K31/505 ,  C07D239/42 ,  A61P35/00

    CPC分类号： C07D239/42

    摘要： The present invention relates to methods for preparing and manufacturing a crystalline form or polymorph of a compound of formula I: in the form of pharmaceutically acceptable salts and polymorphs thereof. The present invention is directed to methods for preparing and manufacturing crystalline polymorphs or forms of specific anilino-pyrimidine benzenesulfonamide compounds. Methods for converting one crystalline form or polymorph of compounds of formula I as their pharmaceutically acceptable salt polymorph to other different crystalline polymorphs of compounds of formula I as their corresponding pharmaceutically acceptable salt are also disclosed.

    摘要翻译： 本发明涉及制备和制备式I化合物的结晶形式或多晶型物的方法：其药学上可接受的盐和多晶型物。 本发明涉及制备和制备结晶多晶型物或特定苯胺基嘧啶苯磺酰胺化合物形式的方法。 还公开了将式I化合物的一种结晶形式或多晶型物作为其药学上可接受的盐多晶型物转化为式I化合物的其它不同结晶多晶型物作为其相应的药学上可接受的盐的方法。