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公开(公告)号：US07893264B2
公开(公告)日：2011-02-22
申请号：US11825606
申请日：2007-07-06
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D221/18 , C07F9/02 , A61K38/12
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08420597B2
公开(公告)日：2013-04-16
申请号：US13598430
申请日：2012-08-29
申请人： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： A61K38/00
CPC分类号： C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20130053577A1
公开(公告)日：2013-02-28
申请号：US13598430
申请日：2012-08-29
申请人： Aesop Cho , Michael O' Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Aesop Cho , Michael O' Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： C07D207/16
CPC分类号： C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US08178491B2
公开(公告)日：2012-05-15
申请号：US12215605
申请日：2008-06-26
申请人： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
发明人： Aesop Cho , Michael O'Neil Hanrahan Clarke , Choung U. Kim , John O. Link , Hyung-jung Pyun , Xiaoning C. Sheng , Qiaoyin Wu
IPC分类号： A61K38/00
CPC分类号： C07D417/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D487/04 , C07K5/0804 , C07K5/0808 , C07K5/0819 , C07K5/0821
摘要： The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20110081314A1
公开(公告)日：2011-04-07
申请号：US12913692
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： A61K38/21 , C07D245/04 , A61K31/675 , A61K31/70 , A61K31/7056 , A61K31/7068 , A61P31/14
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US08586744B2
公开(公告)日：2013-11-19
申请号：US12913704
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D221/18 , C07F9/02 , A61K38/12
CPC分类号： C07F9/65583
摘要： The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.
摘要翻译： 本发明涉及通过向个体施用包含治疗有效量的抗病毒次膦酸盐化合物的药物组合物来治疗与丙型肝炎相关的疾病的方法。
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公开(公告)号：US08674088B2
公开(公告)日：2014-03-18
申请号：US12913692
申请日：2010-10-27
申请人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
发明人： Anthony Casarez , Kleem Chaudhary , Aesop Cho , Michael Clarke , Edward Doerffler , Maria Fardis , Choung U. Kim , Hyungjung Pyun , Xiaoning C. Sheng , Jianying Wang
IPC分类号： C07D487/00
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US07642339B2
公开(公告)日：2010-01-05
申请号：US11184429
申请日：2005-07-18
IPC分类号： A61K38/00
CPC分类号： C07K5/0827 , A61K38/00 , C07F9/572 , C07F9/65583 , C07K5/06191 , C07K5/0808
摘要： The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20080311077A1
公开(公告)日：2008-12-18
申请号：US11632180
申请日：2005-07-18
IPC分类号： A61K38/21 , A61K31/70 , A61K31/4439 , A61K31/40 , A61K31/403 , A61K31/4709 , A61K31/675 , C07F9/06 , C07D401/02 , C07D403/02 , A61P31/12
CPC分类号： C07K5/0827 , A61K38/00 , C07F9/572 , C07F9/65583 , C07K5/06191 , C07K5/0808
摘要： The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译： 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US5840918A
公开(公告)日：1998-11-24
申请号：US704664
申请日：1997-03-19
申请人： Michael D. Lewis , James J. Kowalczyk , Amy E. Christuk , Rulin Fan , Edmund M. Harrington , Xiaoning C. Sheng , Hu Yang , Ana Maria Garcia , Ieharu Hishinuma , Takeshi Nagasu , Kentaro Yoshimatsu
发明人： Michael D. Lewis , James J. Kowalczyk , Amy E. Christuk , Rulin Fan , Edmund M. Harrington , Xiaoning C. Sheng , Hu Yang , Ana Maria Garcia , Ieharu Hishinuma , Takeshi Nagasu , Kentaro Yoshimatsu
IPC分类号： C07D295/18 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/535 , A61K31/5375 , A61K38/00 , A61P35/00 , C07C323/27 , C07C323/52 , C07C323/54 , C07C323/56 , C07C323/58 , C07C323/59 , C07C323/60 , C07D213/40 , C07D277/04 , C07D277/14 , C07D277/16 , C07D307/54 , C07D333/22 , C07D333/24 , C07D417/10 , C07D417/12 , C07K5/06 , C07K5/065 , C07K5/078 , C07C233/00 , C07C321/00 , C07D307/02
CPC分类号： C07D417/10 , C07C323/27 , C07C323/59 , C07C323/60 , C07D277/04 , C07D307/54 , C07D333/24 , C07K5/06034 , C07K5/06043 , C07K5/06078 , C07K5/06139 , A61K38/00
摘要： Peptidomimetic compounds useful in the treatment of Ras-associated human cancers, and other conditions mediated by farnesylated or geranylgeranylated proteins; and synthetic intermediates thereof.
摘要翻译： PCT No.PCT / US95 / 03387第 371日期1997年3月19日 102（e）1997年3月19日PCT PCT 1995年3月15日PCT公布。 公开号WO95 / 25086 日期1995年9月21日可用于治疗Ras相关人类癌症的拟肽化合物，以及由法呢基化或香叶基香叶基化蛋白质介导的其他病症; 及其合成中间体。
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