公开(公告)号：US10683256B2

公开(公告)日：2020-06-16

申请号：US16326940

申请日：2016-08-22

Applicant: BASF SE

Inventor： Xiaoming Xu ,  Chao Huang ,  Timo Frassetto

IPC: C07C201/12 ,  C07C205/12 ,  C07B37/04 ,  C07F9/6568 ,  B01J31/24

Abstract: The present invention relates to a process for preparing substituted biphenyls via Suzuki coupling using specific phosphorus ligands and a solvent mixture containing water, a non-polar organic solvent and a polar aprotic co-solvent.

公开(公告)号：US10273216B2

公开(公告)日：2019-04-30

申请号：US15751349

申请日：2016-08-02

Applicant: BASF SE

Inventor： Eric George Klauber ,  Timo Frassetto ,  Reinhold Niemes ,  Ralf Bauer ,  Jochen Schroeder

IPC: C07D231/22 ,  C07D231/04 ,  C07D231/24

Abstract: The present invention relates to a process for preparing crystalline methyl N-[2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl]-N-methoxycarbamate (I), comprising a) reacting a compound of formula II with an alkylating agent in the presence of a base in the presence of a polar solvent selected from alcohols and ketons; b) the addition of water.

公开(公告)号：US09556141B2

公开(公告)日：2017-01-31

申请号：US14359446

申请日：2012-11-20

Applicant: BASF SE

Inventor： Maximilian Dochnahl ,  Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch

IPC: C07D401/14 ,  C07D471/10 ,  C07D401/04

CPC classification number: C07D401/04 ,  C07D471/10

Abstract: The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carboxylate compound of the formula (I-A) comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined in the description and the claims, with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a carbonylation by reacting it with a reagent selected from the group consisting carbon dioxide or a carbon dioxide equivalent, to obtain a compound of formula (I-A); and it relates to further conversions to yield a N-substituted 1H-pyrazole-5-carbonyl chloride compound of the formula (I)

Abstract translation: 本发明涉及制备式（IA）的N-取代的1H-吡唑-5-羧酸酯化合物的方法，包括以下步骤：i）将式（II）的化合物去质子化，其中变量R1，R2和 r各自如说明书和权利要求中所定义，其中镁 - 有机碱具有碳结合的镁; 和ii）通过使步骤（i）中获得的产物与选自二氧化碳或二氧化碳当量的试剂反应来进行羰基化，得到式（I-A）化合物; 并且涉及进一步转化得到式（I）的N-取代的1H-吡唑-5-碳酰氯化合物，

公开(公告)号：US09518045B2

公开(公告)日：2016-12-13

申请号：US14421351

申请日：2013-08-09

Applicant: BASF SE

Inventor： Maximilian Dochnahl ,  Roland Goetz ,  Joachim Gebhardt ,  Uwe Josef Vogelbacher ,  Timo Frassetto ,  Michael Rack ,  Volker Maywald ,  Bernd Wolf

IPC: C07D413/04 ,  C07D265/36 ,  C07C335/28

CPC classification number: C07D413/04 ,  C07C335/28 ,  C07D265/36

Abstract: The present invention relates to a process for manufacturing benzoxazinones of formula (I), wherein the variables are defined according to the description, by reacting carbamates of formula (II) are reacted with carbamat-benzoxazinones of formula (III) in the presence of a base.

公开(公告)号：US09409894B2

公开(公告)日：2016-08-09

申请号：US14421321

申请日：2013-07-29

Applicant: BASF SE

Inventor： Maximilian Dochnahl ,  Roland Götz ,  Joachim Gebhardt ,  Uwe Josef Vogelbacher ,  Timo Frassetto ,  Michael Rack ,  Volker Maywald ,  Bernd Wolf

IPC: C07C335/28 ,  C07C275/60 ,  C07D265/36 ,  C07D413/04

CPC classification number: C07D413/04 ,  C07C275/60 ,  C07C335/28 ,  C07D265/36

Abstract: The present invention relates to carbamates of formula (I), wherein the variables are defined according to the description, as well as to a process for manufacturing carbamates of formula (I), and to the use of carbamates of formula (I) in manufacturing benzoxazinones of formula (VII).

Abstract translation: 本发明涉及式（I）的氨基甲酸酯，其中根据描述定义变量，以及制备式（I）的氨基甲酸酯的方法，以及式（I）的氨基甲酸酯在制造中的用途 式（VII）的苯并恶嗪酮。

公开(公告)号：US09126905B2

公开(公告)日：2015-09-08

申请号：US14415265

申请日：2013-07-08

Applicant: BASF SE

Inventor： Michael Rack ,  Maximilian Dochnahl ,  Volker Maywald ,  Bernd Wolf ,  Joachim Gebhardt ,  Timo Frassetto ,  Uwe Josef Vogelbacher ,  Roland Götz

IPC: C07C37/62 ,  C07C37/76 ,  C07C17/35 ,  C07C17/093 ,  C07C41/22 ,  C07C51/363 ,  C07C209/74 ,  C07D213/73

CPC classification number: C07C37/62 ,  C07C17/093 ,  C07C17/35 ,  C07C37/76 ,  C07C41/22 ,  C07C51/363 ,  C07C209/74 ,  C07C245/20 ,  C07D213/73 ,  C07C39/27

Abstract: The present invention relates to a process for manufacturing fluoroaromatics of formula (I), A-F   (I) comprising step a) diazotization of aminoaromatics of formula (II) in anhydrous HF with an aqueous solution of a diazotizing agent; followed by step b) thermic decomposition of the diazonium salt of formula (III) resulting from step a); wherein the variables are defined according to the description.

Abstract translation: 本发明涉及一种制备式（I）的氟代芳族化合物的方法，A-F（I）包括步骤a）将式（II）的氨基芳族化合物在无水HF中的重氮化与重氮化剂的水溶液重氮化; 然后步骤b）由步骤a）得到的式（III）的重氮盐的热分解; 其中根据描述定义变量。

公开(公告)号：US20150087843A1

公开(公告)日：2015-03-26

申请号：US14359446

申请日：2012-11-20

Applicant: BASF SE

Inventor： Maximilian Dochnahl ,  Karsten Koerber ,  Prashant Deshmukh ,  Florian Kaiser ,  Michael Rack ,  Timo Frassetto ,  Gemma Veitch

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07D471/10

Abstract: The present invention relates to a process for preparing an N-substituted 1H-pyrazole-5-carboxylate compound of the formula (I-A) comprising the steps of i) deprotonating a compound of the formula (II) in which the variables R1, R2 and r are each as defined in the description and the claims, with a magnesium-organic base having a carbon bound magnesium; and ii) subjecting the product obtained in step (i) to a carbonylation by reacting it with a reagent selected from the group consisting carbon dioxide or a carbon dioxide equivalent, to obtain a compound of formula (I-A); and it relates to further conversions to yield a N-substituted 1H-pyrazole-5-carbonyl chloride compound of the formula (I)

Abstract translation: 本发明涉及制备式（IA）的N-取代的1H-吡唑-5-羧酸酯化合物的方法，包括以下步骤：i）将式（II）的化合物去质子化，其中变量R1，R2和 r各自如说明书和权利要求中所定义，其中镁 - 有机碱具有碳结合的镁; 和ii）通过使步骤（i）中获得的产物与选自二氧化碳或二氧化碳当量的试剂反应来进行羰基化，得到式（I-A）化合物; 并且涉及进一步转化得到式（I）的N-取代的1H-吡唑-5-碳酰氯化合物，

公开(公告)号：US20140316131A1

公开(公告)日：2014-10-23

申请号：US14364160

申请日：2012-12-20

Applicant: BASF SE

Inventor： Bernd Wolf ,  Volker Maywald ,  Uwe Josef Vogelbacher ,  Michael Rack ,  Maximilian Dochnahl ,  Michael Keil ,  Timo Frassetto ,  Joachim Gebhardt

IPC: C07D413/04

CPC classification number: C07D413/04 ,  A01N43/84

Abstract: The present invention relates to a process for manufacturing triazinon-benzoxazinones of formula (I), by reacting amino-benzoxazinones of formula (II) with 1,1′-carbonyldiimidazole (CDI) and a (thio)urea compound of formula (III); wherein the variables are defined according to the description.

Abstract translation: 本发明涉及通过使式（II）的氨基 - 苯并嗪酮与1,1'-羰基二咪唑（CDI）和式（III）的（硫代）脲化合物反应制备式（I）的三嗪酮 - 苯并恶嗪酮的方法， ; 其中根据描述定义变量。