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公开(公告)号：US09498480B2
公开(公告)日：2016-11-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , C07D487/04 , A61K31/522 , A61K45/06 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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公开(公告)号：US08921377B2
公开(公告)日：2014-12-30
申请号：US13851373
申请日：2013-03-27
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Walter Kroh , Andreas Knorr , Eva-Maria Becker , Frank Wunder , Volkhart Min-Jian Li , Elke Hartmann , Joachim Mittendorf , Karl-Heinz Schlemmer , Rolf Jautelat , Donald Bierer
IPC分类号： A61K31/53 , A01N43/64 , C07D239/02 , C07D513/02
CPC分类号： A61K31/506 , A61K45/06 , C07C57/145 , C07C309/04 , C07C309/05 , C07D471/04
摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的5-氟-1H-吡唑并吡啶，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及它们用于制备用于治疗和/ 或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2017/04/18/US09624214B2/abs.jpg.150x150.jpg)
公开(公告)号：US09624214B2
公开(公告)日：2017-04-18
申请号：US14070180
申请日：2013-11-01
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haβfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： A61K31/4353 , C07D471/04 , A61K31/437 , A61K31/439 , A61K31/4985 , A61K45/06 , C07D471/08 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D519/00
CPC分类号： A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![Amino-substituted imidazo[1,2-A] pyridinecarboxamides and their use](/abs-image/US/2020/05/26/US10662185B2/abs.jpg.150x150.jpg)
公开(公告)号：US10662185B2
公开(公告)日：2020-05-26
申请号：US16025087
申请日：2018-07-02
发明人： Alexandros Vakalopoulos , Markus Follman , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haßfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： C07D471/04 , A61K31/437 , A61K31/439 , A61K31/4985 , A61K45/06 , C07D471/08 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D519/00 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/55 , A61K31/4375 , A61K31/4725
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides of the general formula (I) to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![N-substituted 8-[(2,6-difluorobenzyl)oxy]-2,6- dimethylimidazo[1,2-a]pyrazin-3-carboxamide derivatives as stimulators of soluble guanylate cyclase (SGC) for the treatment of cardiovascular diseases](/abs-image/US/2018/12/11/US10150773B2/abs.jpg.150x150.jpg)
公开(公告)号：US10150773B2
公开(公告)日：2018-12-11
申请号：US15548310
申请日：2016-02-02
发明人： Alexandros Vakalopoulos , Damian Brockschnieder , Frank Wunder , Johannes-Peter Stasch , Tobias Marquardt , Lisa Dietz , Min Jian Volkhart Li
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/695 , A61K45/06 , C07B59/00 , C07F7/08
摘要： The present application relates to novel substituted imidazo[1,2-a]pyrazine carboxamides of general formula (I) to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US10053428B2
公开(公告)日：2018-08-21
申请号：US15600132
申请日：2017-05-19
发明人： Michael Hahn , Markus Follmann , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin , Walter Hübsch
IPC分类号： A61K31/4706 , C07D215/48 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4709 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
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![AMINO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE](/abs-image/US/2015/10/01/US20150274719A1/abs.jpg.150x150.jpg)
17.发明申请公开(公告)号：US20150274719A1
公开(公告)日：2015-10-01
申请号：US14440509
申请日：2013-11-04
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Hassfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61K31/496 , A61K31/541 , A61K31/4985 , C07D519/00 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE](/abs-image/US/2015/06/04/US20150152050A1/abs.jpg.150x150.jpg)
18.发明申请N-[3-(2-CARBOXYETHYL)PHENYL]PIPERIDIN-1-YLACETAMIDE DERIVATIVES AND USE THEREOF AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE 有权N- [3-（2-羧基乙基）苯基]哌啶-1-基乙酰胺衍生物及其作为可溶性葡萄糖酸环化酶的活化剂的用途公开(公告)号：US20150152050A1
公开(公告)日：2015-06-04
申请号：US14402232
申请日：2013-05-17
发明人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Friederike Stoll , Andreas Knorr
IPC分类号： C07D211/14 , A61K45/06 , A61K31/472 , A61K31/438 , A61K31/451 , C07D217/04 , A61K31/445 , C07D221/20
CPC分类号： C07D211/14 , A61K31/438 , A61K31/445 , A61K31/451 , A61K31/472 , A61K45/06 , C07D211/06 , C07D211/18 , C07D211/46 , C07D217/04 , C07D221/20 , C07D295/15
摘要： The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新型取代的2-（哌啶-1-基）乙酰胺衍生物，其制备方法及其用于治疗和/或预防疾病的用途，以及其用于生产用于治疗和 /或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![Substituted pyrazolo[1,5-a]-pyridine-3-carboxamides and use thereof](/abs-image/US/2019/02/26/US10214526B2/abs.jpg.150x150.jpg)
公开(公告)号：US10214526B2
公开(公告)日：2019-02-26
申请号：US15548158
申请日：2016-02-02
发明人： Alexandros Vakalopoulos , Damian Brockschnieder , Frank Wunder , Johannes-Peter Stasch , Tobias Marquardt , Lisa Dietz , Min Jian Volkhart Li
IPC分类号： C07D471/04
摘要： The present application relates to novel substituted pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2018/08/21/US10052312B2/abs.jpg.150x150.jpg)
公开(公告)号：US10052312B2
公开(公告)日：2018-08-21
申请号：US15447205
申请日：2017-03-02
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haβfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： A61K31/437 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4985 , A61K31/439 , A61K31/4709 , A61K31/4545 , A61K31/444 , A61K31/55
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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