公开(公告)号：US20180093973A1

公开(公告)日：2018-04-05

申请号：US15699857

申请日：2017-12-20

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07D487/04 ,  C07D401/14 ,  C07D413/14 ,  C07D409/14 ,  C07D417/14 ,  C07D495/04 ,  C07D513/04 ,  C07D417/12

CPC classification number: C07D403/12 ,  A61K31/506 ,  C07D239/30 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/027

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

公开(公告)号：US09499485B2

公开(公告)日：2016-11-22

申请号：US14420025

申请日：2013-08-05

Applicant: BIOGEN MA INC.

Inventor： Kevin Guckian ,  Gnanasambandam Kumaravel ,  Bin Ma ,  Lihong Sun ,  Zhili Xin ,  Lei Zhang

IPC: C07D451/02 ,  C07D211/62 ,  A61K31/122 ,  A61K45/06 ,  A61K31/192 ,  A61K31/216 ,  A61K31/439 ,  A61K31/445 ,  A61K31/45 ,  C07C229/14 ,  C07C229/48 ,  C07D211/60 ,  A61K31/196 ,  A61K31/197 ,  A61K31/198 ,  A61K31/46 ,  C07D211/34 ,  C07D451/14

CPC classification number: C07D211/62 ,  A61K31/122 ,  A61K31/192 ,  A61K31/196 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/439 ,  A61K31/445 ,  A61K31/45 ,  A61K31/46 ,  A61K45/06 ,  C07C229/14 ,  C07C229/48 ,  C07C2601/14 ,  C07D211/34 ,  C07D211/60 ,  C07D451/02 ,  C07D451/14 ,  A61K2300/00

Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。

公开(公告)号：US20240083900A1

公开(公告)日：2024-03-14

申请号：US18036853

申请日：2021-11-12

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Isaac Marx ,  Jürgen Schulz ,  George Vandeveer ,  Robin Prince ,  Marta Nevalainen ,  TeYu Chen ,  Zain Yousaf ,  Martin Himmelbauer ,  Vatee Pattaropong ,  John Howard Jones ,  Edward Yin-Shiang Lin ,  Felix Gonzalez Lopez de Turiso ,  Thomas Purgett ,  Andrew George Capacci ,  Simone Sciabola

IPC: C07D487/04 ,  C07D471/04 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: Provided are compounds of Formula (I′): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

公开(公告)号：US20210340135A1

公开(公告)日：2021-11-04

申请号：US17183702

申请日：2021-02-24

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC: C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  A61P43/00 ,  C07D405/14 ,  C07D471/04 ,  A61P1/16

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US10406144B2

公开(公告)日：2019-09-10

申请号：US16020696

申请日：2018-06-27

Applicant: BIOGEN MA INC.

Inventor： Jermaine Thomas ,  Sha Mi ,  Edward Yin-Shiang Lin ,  Guo Zhu Zheng ,  Bin Ma ,  Richard D. Caldwell ,  Kevin M. Guckian ,  Gnanasambandam Kumaravel

IPC: A61K31/445 ,  A61K31/225 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/55 ,  A61K31/695 ,  A61K39/395 ,  A61K38/21 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D401/06 ,  C07D405/12 ,  C07D215/20 ,  C07K16/28

Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.

公开(公告)号：US20180369215A1

公开(公告)日：2018-12-27

申请号：US16020696

申请日：2018-06-27

Applicant: BIOGEN MA INC.

Inventor： Jermaine Thomas ,  Sha Mi ,  Edward Yin-Shiang Lin ,  Guo Zhu Zheng ,  Bin Ma ,  Richard D. Caldwell ,  Kevin M. Guckian ,  Gnanasambandam Kumaravel

IPC: A61K31/445 ,  A61K31/517 ,  C07D211/34 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/55 ,  A61K31/225 ,  A61K31/695 ,  C07K16/28 ,  A61K38/21 ,  A61K39/395 ,  C07D215/20 ,  C07D405/12 ,  C07D401/06 ,  C07D211/62 ,  C07D211/60

CPC classification number: A61K31/445 ,  A61K31/225 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/517 ,  A61K31/55 ,  A61K31/695 ,  A61K38/21 ,  A61K39/3955 ,  C07D211/34 ,  C07D211/60 ,  C07D211/62 ,  C07D215/20 ,  C07D401/06 ,  C07D405/12 ,  C07K16/2842

Abstract: Compounds of formula (I) or (II) can modulate the activity of S1P receptors.

公开(公告)号：US20180362522A1

公开(公告)日：2018-12-20

申请号：US16113455

申请日：2018-08-27

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC: C07D417/14 ,  A61P43/00 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D417/14 ,  A61K31/44 ,  A61K31/443 ,  A61K31/506 ,  A61P43/00 ,  C07B2200/13 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20180002356A1

公开(公告)日：2018-01-04

申请号：US15621665

申请日：2017-06-13

Applicant: BIOGEN MA INC.

Inventor： Richard D. Caldwell ,  Kevin M. Guckian ,  Gnanasambandam Kumaravel ,  Wen-Cherng Lee ,  Edward Yin-Shiang Lin ,  Xiaogao Liu ,  Bin Ma ,  Daniel M. Scott ,  Zhan Shi ,  Jermaine Thomas ,  Arthur G. Taveras ,  Guo Zhu Zheng

IPC: C07F9/6512 ,  C07D263/24 ,  C07D215/20 ,  C07C217/58 ,  C07C233/47 ,  C07C229/36 ,  C07F9/60 ,  C07D239/80

CPC classification number: C07F9/6512 ,  C07C217/58 ,  C07C217/74 ,  C07C229/36 ,  C07C233/47 ,  C07C2602/10 ,  C07D215/06 ,  C07D215/20 ,  C07D215/227 ,  C07D233/32 ,  C07D239/74 ,  C07D239/80 ,  C07D263/24 ,  C07D277/64 ,  C07D401/04 ,  C07F9/091 ,  C07F9/60 ,  C07F9/65744

Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

公开(公告)号：US09850206B2

公开(公告)日：2017-12-26

申请号：US14443912

申请日：2013-11-20

Applicant: BIOGEN MA INC.

Inventor： Hairuo Peng ,  Edward Yin-Shiang Lin ,  Jianhua Chao ,  Zhili Xin ,  Bin Ma ,  Kevin Guckian ,  Timothy Chan ,  Gnanasambandam Kumaravel ,  Arthur G. Taveras

IPC: C07D211/22 ,  C07D213/74 ,  C07D401/12 ,  C07D237/22 ,  C07D239/47 ,  C07D207/08 ,  C07D211/56 ,  C07D211/62 ,  C07D295/15 ,  C07D295/155 ,  C07D211/70 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D401/04 ,  C07D403/04

CPC classification number: C07D211/22 ,  A61K31/451 ,  A61K31/4545 ,  A61K31/495 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D207/08 ,  C07D211/56 ,  C07D211/62 ,  C07D211/70 ,  C07D213/74 ,  C07D237/22 ,  C07D239/47 ,  C07D295/15 ,  C07D295/155 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04

Abstract: Compounds of formula (I) wherein: X is —O—, —S(O)r—, —CH2—, or —NR—, wherein r is 0, 1, or 2; X1, X2, and X5 are each independently CR7 or N; one of X3 or X4 is C and is attached by a single bond to -L-, and the other is CR7 or N, provided that no more than three of X1, X2, X3, X or X5 are N; Ring A is monocyclic C5-6scycloalkyl or a 5- to 6-membered monocyclic heterocyclyl comprising from 1 to 5 heteroatoms independently selected from N, S, or O; wherein Ring A is further optionally substituted with from 1 to 3 R4; provided that Ring A is not morpholinyl, thiomorpholinyl or tetrahydro-2H-pyranyl; L is a bond, —O—, —NR—, —S(O)n—, —CH2—, or —C(O)—, wherein n is 0, 1, or 2; 1 2 L1 is an C1-8alkylene, C3-scycloalkylene, —CH2-L2-, or a 3- to 8-membered heterocyclylene comprising 1 to 5; R1 is C6-20alkyl or a monocyclic C3-8cycloalkyl; wherein said C3-8cycloalkyl is substituted with at least one R6 and may be optionally substituted with from 1 to 5 additional R6 substituents, wherein R6 for each occurrence is independently selected; and R2 is —C(O)OR3, —C(O)N(R3)—S(O)2R3, —S(O)2OR3, —C(O)NHC(O)R3, —Si(O)OH, —B(OH)2, —N(R3)S(O)2R3, —S(O)2N(R3)2, —O—P(O)(OR3)2, or —P(O)(OR3)2, —CN, —S(O)2NHC(O)R3, —C(O)NHS(O)2R3, —C(O)NHOH, —C(O)NHCN, —CH(CF3)OH, —C(CF3)2OH, or a selected heteroaryl or heterocyclyl; and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

公开(公告)号：US09809577B2

公开(公告)日：2017-11-07

申请号：US15103749

申请日：2014-12-11

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Timothy Raymond Chan ,  Lihong Sun ,  Lei Zhang ,  Gnanasambandam Kumaravel ,  Joseph P. Lyssikatos ,  Kevin Koch ,  Hua Miao

IPC: C07D403/12 ,  C07D417/14 ,  C07D495/04 ,  C07D409/14 ,  C07D401/14 ,  C07D513/04 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04

CPC classification number: C07D403/12 ,  A61K31/506 ,  C07D239/30 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07F5/027

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.