公开(公告)号：US20200223852A1

公开(公告)日：2020-07-16

申请号：US16631915

申请日：2018-07-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C.D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

公开(公告)号：US09518058B2

公开(公告)日：2016-12-13

申请号：US14914330

申请日：2014-08-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Martin D. Eastgate ,  Gregory L. Beutner ,  Benjamin Cohen ,  Nicolas Cuniere ,  Lopa V. Desai ,  Monica Fitzgerald ,  Qi Gao ,  Michael Bryan Hay ,  Michael Joseph Lawler ,  Paul C. Lobben ,  Christopher S. Regens ,  Thorsten Rosner ,  Neil Strotman ,  Carolyn S. Wei ,  Yi Xiao ,  Bin Zheng ,  Keming Zhu

IPC: C07D471/14 ,  C07D207/42 ,  C07D403/04 ,  C07D231/16

CPC classification number: C07D471/14 ,  C07D207/42 ,  C07D231/16 ,  C07D403/04

Abstract: The invention relates to an improved process for synthesizing N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (I) Compound (I) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.