公开(公告)号：US11254679B2

公开(公告)日：2022-02-22

申请号：US16631915

申请日：2018-07-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C. D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

公开(公告)号：US09249171B2

公开(公告)日：2016-02-02

申请号：US14402231

申请日：2013-05-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Tamas Benkovics ,  Zhongping Shi ,  Prashant P. Deshpande ,  Zhiwei Guo ,  David R. Kronenthal ,  Chris Sfouggatakis

IPC: C07H15/20 ,  C07H19/06 ,  C12P19/38 ,  C07D309/10 ,  C07D407/04 ,  C07D307/20

CPC classification number: C07H15/20 ,  C07D307/20 ,  C07D309/10 ,  C07D407/04 ,  C07H19/06 ,  C12P19/385

Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.

Abstract translation: 制备式I化合物的方法利用起始化合物以及稍后的亚硫酰亚胺和亚砜工艺步骤。

公开(公告)号：US20150140610A1

公开(公告)日：2015-05-21

申请号：US14402231

申请日：2013-05-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adrian Ortiz ,  Tamas Benkovics ,  Zhongping Shi ,  Prashant P. Deshpande ,  Zhiwei Guo ,  David R. Kronenthal ,  Chris Sfouggatakis

IPC: C07H15/20 ,  C07H19/06 ,  C12P19/38

CPC classification number: C07H15/20 ,  C07D307/20 ,  C07D309/10 ,  C07D407/04 ,  C07H19/06 ,  C12P19/385

Abstract: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.

Abstract translation: 制备式I化合物的方法利用起始化合物以及稍后的亚硫酰亚胺和亚砜工艺步骤。

公开(公告)号：US20220177482A1

公开(公告)日：2022-06-09

申请号：US17677312

申请日：2022-02-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C.D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.

公开(公告)号：US20200223852A1

公开(公告)日：2020-07-16

申请号：US16631915

申请日：2018-07-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Burcu Selin Aytar ,  Alina Borovika ,  Collin Chan ,  Joerg Deerberg ,  Nathan R. Domagalski ,  Martin D. Eastgate ,  Yu Fan ,  Michael David Bengt Fenster ,  Robert V. Forest ,  Francisco Gonzalez-Bobes ,  Rebecca A. Green ,  Matthew R. Hickey ,  Nathaniel David Kopp ,  Thomas E. La Cruz ,  Kathleen Lauser ,  Hong Geun Lee ,  David K. Leahy ,  Helen Y. Luo ,  Thomas M. Razler ,  Scott A. Savage ,  Chris Sfouggatakis ,  Maxime C.D. Soumeillant ,  Serge Zaretsky ,  Bin Zheng ,  Ye Zhu

IPC: C07D487/04

Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.