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公开(公告)号：US20150038716A1
公开(公告)日：2015-02-05
申请号：US14516641
申请日：2014-10-17
Applicant: Bristol-Myers Squibb Company
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D471/04 , C07D405/04 , C07D207/333
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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![Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide](/abs-image/US/2022/02/22/US11254679B2/abs.jpg.150x150.jpg)
公开(公告)号：US11254679B2
公开(公告)日：2022-02-22
申请号：US16631915
申请日：2018-07-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C. D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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公开(公告)号：US20160152644A1
公开(公告)日：2016-06-02
申请号：US14986816
申请日：2016-01-04
Applicant: Bristol-Myers Squibb Company
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07F9/6561 , C07C213/08
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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4.发明申请METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND 有权制备HIV连接抑制剂哌嗪类化合物的方法公开(公告)号：US20150038712A1
公开(公告)日：2015-02-05
申请号：US14516661
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07F1/02 , C07D471/04
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
Abstract translation: 使用原料制备化合物的方法
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公开(公告)号：US09403821B2
公开(公告)日：2016-08-02
申请号：US14516649
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07F9/02 , C07D471/04 , C07F9/6509
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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Patent Agency Ranking
公开(公告)号：US09376458B2
公开(公告)日：2016-06-28
申请号：US14516664
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07F9/09 , C07F9/6561 , C07D471/04 , C07C213/08 , C07F1/02 , C07D207/333 , C07D405/04
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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公开(公告)号：US20160108029A1
公开(公告)日：2016-04-21
申请号：US14516649
申请日：2014-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D471/04
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
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8.发明授权Methods for the preparation of HIV attachment inhibitor piperazine prodrug compound 有权制备HIV附着抑制剂哌嗪前药化合物的方法公开(公告)号：US08889869B2
公开(公告)日：2014-11-18
申请号：US13760526
申请日：2013-02-06
Applicant: Bristol-Myers Squibb Company
Inventor： Martin D. Eastgate , Michael S. Bultman , Ke Chen , Dayne Dustan Fanfair , Richard J. Fox , Thomas E. La Cruz , Boguslaw M. Mudryk , Christina Ann Risatti , James H. Simpson , Maxime C. Soumeillant , Jonathan Clive Tripp , Yi Xiao
IPC: C07D471/04 , C07C213/08 , C07F9/6561
CPC classification number: C07D471/04 , C07C213/08 , C07D207/333 , C07D405/04 , C07F1/02 , C07F9/098 , C07F9/650952 , C07F9/6561
Abstract: A method for making the compound is set forth utilizing the starting material
Abstract translation: 使用原料制备化合物的方法
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![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2022/06/09/US20220177482A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220177482A1
公开(公告)日：2022-06-09
申请号：US17677312
申请日：2022-02-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2020/07/16/US20200223852A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200223852A1
公开(公告)日：2020-07-16
申请号：US16631915
申请日：2018-07-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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