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![Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide](/abs-image/US/2022/02/22/US11254679B2/abs.jpg.150x150.jpg)
公开(公告)号：US11254679B2
公开(公告)日：2022-02-22
申请号：US16631915
申请日：2018-07-19
发明人： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C. D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC分类号： C07D487/04
摘要： The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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2.发明申请PROCESS FOR THE PREPARATION OF CYCLOHEPTAPYRIDINE CGRP RECEPTOR ANTAGONISTS 审中-公开环磷酰胺CGRP受体拮抗剂的制备方法公开(公告)号：US20150099887A1
公开(公告)日：2015-04-09
申请号：US14568370
申请日：2014-12-12
发明人： David K. Leahy , Yu Fan , Collin Chan , Lopa V. Desai , Sunil S. Patel , Masano Sugiyama
IPC分类号： C07F7/18 , C07D471/04 , C07D221/04
CPC分类号： C07F7/1804 , C07D221/04 , C07D471/04
摘要： The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process.
摘要翻译： 本公开一般涉及制备式I化合物的方法，包括在该方法中有用的合成中间体。
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3.发明申请Process for the Preparation of Cycloheptapyridine CGRP Receptor Antagonists 审中-公开环庚三烯CGRP受体拮抗剂的制备方法公开(公告)号：US20140135500A1
公开(公告)日：2014-05-15
申请号：US14156626
申请日：2014-01-16
发明人： David K. Leahy , Yu Fan , Collin Chan , Lopa V. Desai , Sunil S. Patel , Masano Sugiyama
IPC分类号： C07D221/04 , C07F7/18
CPC分类号： C07F7/1804 , C07D221/04 , C07D471/04
摘要： The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process.
摘要翻译： 本公开一般涉及制备式I化合物的方法，包括在该方法中有用的合成中间体。
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4.发明申请Process for the Preparation of Cycloheptapyridine CGRP Receptor Antagonists 审中-公开环庚三烯CGRP受体拮抗剂的制备方法公开(公告)号：US20150361047A1
公开(公告)日：2015-12-17
申请号：US14833891
申请日：2015-08-24
发明人： David K. Leahy , Yu Fan , Collin Chan , Lopa V. Desai , Sunil S. Patel , Masano Sugiyama
IPC分类号： C07D221/04 , C07F7/18
CPC分类号： C07F7/1804 , C07D221/04 , C07D471/04
摘要： The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process.
摘要翻译： 本公开一般涉及制备式I化合物的方法，包括在该方法中有用的合成中间体。
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![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2022/06/09/US20220177482A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220177482A1
公开(公告)日：2022-06-09
申请号：US17677312
申请日：2022-02-22
发明人： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC分类号： C07D487/04
摘要： The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2020/07/16/US20200223852A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200223852A1
公开(公告)日：2020-07-16
申请号：US16631915
申请日：2018-07-19
发明人： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC分类号： C07D487/04
摘要： The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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公开(公告)号：US09718845B2
公开(公告)日：2017-08-01
申请号：US15225261
申请日：2016-08-01
发明人： David K. Leahy , Yu Fan , Collin Chan , Lopa V. Desai , Sunil S. Patel , Masano Sugiyama
IPC分类号： C07D221/06 , C07D221/16 , C07F7/18 , C07D221/04 , C07D471/04
CPC分类号： C07F7/1804 , C07D221/04 , C07D471/04
摘要： The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process.
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8.发明申请PROCESS FOR THE PREPARATION OF CYCLOHEPTAPYRIDINE CGRP RECEPTOR ANTAGONISTS 审中-公开环磷酰胺CGRP受体拮抗剂的制备方法公开(公告)号：US20160340373A1
公开(公告)日：2016-11-24
申请号：US15225261
申请日：2016-08-01
发明人： David K. Leahy , Yu Fan , Collin Chan , Lopa V. Desai , Sunil S. Patel , Masano Sugiyama
IPC分类号： C07F7/18 , C07D471/04 , C07D221/04
CPC分类号： C07F7/1804 , C07D221/04 , C07D471/04
摘要： The disclosure generally relates to a process for the preparation of compounds of formula I, including synthetic intermediates which are useful in the process.
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