公开(公告)号：US20150065505A1

公开(公告)日：2015-03-05

申请号：US14390172

申请日：2013-03-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jennifer X. Qiao ,  Carol Hui Hu ,  Tammy C. Wang ,  Ji Jiang

IPC: C07D239/557 ,  C07D495/04 ,  C07D487/04 ,  C07D417/12 ,  C07D401/14 ,  C07D401/12 ,  C07D403/12

CPC classification number: C07D239/557 ,  A61K31/4709 ,  A61K31/505 ,  C07D239/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04

Abstract: The present invention provides compounds of Formula (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供了如说明书中所定义的式（I）化合物和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US20140031345A1

公开(公告)日：2014-01-30

申请号：US14038814

申请日：2013-09-27

Applicant: Bristol-Myers Squibb Company

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  Ji Jiang ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee

IPC: C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D413/14 ,  C07D403/04 ,  A61K45/06 ,  C07D405/12 ,  A61K31/5377 ,  C07D471/04 ,  C07D513/04 ,  A61K31/549 ,  C07D401/14 ,  C07D417/14

CPC classification number: C07D401/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract translation: 其中A，X，Y，Z，R 1和R 24在本文中描述的式I化合物。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。

公开(公告)号：US20140011799A1

公开(公告)日：2014-01-09

申请号：US13936311

申请日：2013-07-08

Applicant: Bristol-Myers Squibb Company

Inventor： James A. Johnson ,  Ji Jiang ,  Soong-Hoon Kim ,  Zulan Pi ,  Jennifer X. Qiao ,  George O. Tora ,  Tammy C. Wang ,  Heather Finlay

IPC: C07D417/06 ,  C07D417/14

CPC classification number: C07D417/06 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US10173991B2

公开(公告)日：2019-01-08

申请号：US15108584

申请日：2015-01-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  Zulan Pi ,  Jennifer X. Qiao ,  Soong-Hoon Kim ,  Tammy C. Wang ,  Ji Jiang ,  Heather Finlay ,  John Lloyd

IPC: C07D417/04 ,  C07D277/64 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used medicaments.

公开(公告)号：US20160355507A1

公开(公告)日：2016-12-08

申请号：US15171276

申请日：2016-06-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  Soong-Hoon Kim ,  R. Michael Lawrence ,  Michael C. Myers ,  Hannguang J. Chao ,  Monique Phillips ,  Ji Jiang

IPC: C07D413/04 ,  C07D417/14 ,  C07D498/04 ,  C07D413/14

CPC classification number: C07D413/04 ,  C07D401/04 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

Abstract translation: 其中所有变量如说明书中所定义，以及包含任何这些新化合物的组合物。 这些化合物是可用作药物的APJ激动剂。

公开(公告)号：US09493412B2

公开(公告)日：2016-11-15

申请号：US14346751

申请日：2012-09-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jennifer X. Qiao ,  Heather Finlay ,  Ji Jiang ,  John Lloyd ,  Carol Hui Hu ,  Zulan Pi ,  George O. Tora ,  James Neels ,  Jon J. Hangeland ,  Todd J. Friends

IPC: C07D207/38 ,  C07D409/12 ,  C07D471/04 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D403/12 ,  C07D401/04 ,  C07D405/12 ,  C07F7/08

CPC classification number: C07D207/38 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07F7/0812

Abstract: The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

公开(公告)号：US20150239879A1

公开(公告)日：2015-08-27

申请号：US14427105

申请日：2013-09-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： George O. Tora ,  Heather Finlay ,  Carol Hui Hu ,  Ji Jiang ,  James A. Johnson ,  Soong-Hoon Kim ,  John Lloyd ,  Brandon Parkhurst ,  Zulan Pi ,  Jennifer X. Qiao ,  Tammy C. Wang

IPC: C07D417/06 ,  C07D417/14

CPC classification number: C07D417/06 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicament.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US20140213588A1

公开(公告)日：2014-07-31

申请号：US14346747

申请日：2012-09-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Lynn Abell ,  Leonard Adam ,  Cullen L. Cavallaro ,  Heather Finlay ,  Todd J. Friends ,  Jon J. Hangeland ,  Ji Jiang ,  R. Michael Lawrence ,  Jennifer X. Qiao ,  Carol Hui Hu ,  Tammy C. Wang

IPC: C07D417/06 ,  C07D417/04 ,  C07D409/04 ,  C07D413/06 ,  C07D405/06 ,  C07D233/61 ,  C07D401/06 ,  C07D207/277 ,  C07D405/04

CPC classification number: C07D207/277 ,  C07D207/28 ,  C07D207/38 ,  C07D233/61 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments. The disclosure also provides a novel method of treating diseases or conditions related to the activity of endothelial lipase by use of compounds according to Formula (II): as defined in the specification and compositions comprising any of the compounds.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。 本公开还提供了一种通过使用根据式（II）的化合物来治疗与内皮脂肪酶活性相关的疾病或病症的新方法：如说明书中所定义和包含任何化合物的组合物。

公开(公告)号：US20140045811A1

公开(公告)日：2014-02-13

申请号：US13944921

申请日：2013-07-18

Applicant: Bristol-Myers Squibb Company

Inventor： Heather Finlay ,  Ji Jiang ,  Soong-Hoon Kim ,  Brandon Parkhurst ,  Jennifer X. Qiao ,  Tammy C. Wang ,  Zulan Pi ,  George O. Tora ,  John Lloyd ,  James A. Johnson

IPC: C07D277/64 ,  C07D417/10 ,  C07D417/12 ,  C07D417/04 ,  C07D417/14

CPC classification number: C07D277/64 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Abstract translation: 本发明提供式（I）化合物：如说明书中所定义和包含任何这些新化合物的组合物。 这些化合物是可用作药物的内皮脂肪酶抑制剂。

公开(公告)号：US20210380578A1

公开(公告)日：2021-12-09

申请号：US16759782

申请日：2018-10-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joseph E. Carpenter ,  Jianxin Feng ,  Ji Jiang ,  Soong-Hoon Kim ,  Ying Wang ,  Gang Wu

IPC: C07D417/14 ,  C07D413/14 ,  C07D413/06 ,  C07D471/08 ,  C07D487/04 ,  C07D401/14 ,  C07D471/04 ,  C07D513/04

Abstract: The present invention provides compounds of Formula (I), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.