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公开(公告)号：US20180110873A1
公开(公告)日：2018-04-26
申请号：US15789027
申请日：2017-10-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ivar M. MCDONALD , Prasanna SIVAPRAKASAM , Christiana I. IWUAGWU , Kevin M. Peese , Heng CHENG , Naidu S. CHOWDARI , Sanjeev GANGWAR
IPC: A61K47/68 , C07F7/08 , C07K5/062 , C07D471/04 , C07D519/00
CPC classification number: A61K47/6803 , C07D471/04 , C07D519/00 , C07F7/0814 , C07K5/06026
Abstract: A compound capable of inhibiting cell proliferation, having a structure according to formula (I) wherein the variables in formula (I) are as defined in the specification. Such compounds are useful as anti-cancer agents, especially in antibody-drug conjugates.
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Patent Agency Ranking
![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS](/abs-image/US/2023/11/02/US20230348468A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230348468A1
公开(公告)日：2023-11-02
申请号：US17793278
申请日：2021-01-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Matthew COX , Naidu S. CHOWDARI , Ashvinikumar V. GAVAI , Sanjeev GANGWAR , Christine M. TARBY , Yam B. POUDEL , Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH
IPC: C07D487/04 , C07K16/28
CPC classification number: C07D487/04 , C07K16/2818 , C07K16/2827
Abstract: Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). (I) (II) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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公开(公告)号：US20230159552A1
公开(公告)日：2023-05-25
申请号：US17916947
申请日：2021-04-08
Inventor： Dale L. BOGER , Naidu S. CHOWDARI , Sanjeev GANGWAR
IPC: C07D493/10 , A61K31/35
CPC classification number: C07D493/10 , A61K31/35
Abstract: Compounds according to formula (I), where R is as defined herein, have anti-cancer properties.
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![1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS AND METHODS AND USES THEREFOR](/abs-image/US/2023/05/04/US20230140047A1/abs.jpg.150x150.jpg)
14.发明申请公开(公告)号：US20230140047A1
公开(公告)日：2023-05-04
申请号：US18081558
申请日：2022-12-14
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： YAM B. POUDEL , Sanjeev GANGWAR , Liqi HE , Prasanna SIVAPRAKASAM , Matthias BROEKEMA , Matthew COX , Christine M. TARBY , Qian ZHANG , Naidu S. CHOWDARI
IPC: A61K31/519 , A61K47/60 , A61K39/395 , C07D487/04 , A61P35/00 , A61K31/395
Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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15.发明申请HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING 有权异丁烯二苯并二恶英二聚体，其结合物及其制备和使用方法公开(公告)号：US20170057959A1
公开(公告)日：2017-03-02
申请号：US15351955
申请日：2016-11-15
Applicant: Bristol-Myers Squibb Company
Inventor： Ivar M. MCDONALD , Naidu S. CHOWDARI , Walter Lewis JOHNSON , Yong ZHANG , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07D471/04
CPC classification number: C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Abstract translation: 并且式（I），（Ia）和（Ib）中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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16.发明申请HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING 有权异丁烯二苯并二恶英二聚体，其结合物及其制备和使用方法公开(公告)号：US20160199510A1
公开(公告)日：2016-07-14
申请号：US14994378
申请日：2016-01-13
Applicant: Bristol-Myers Squibb Company
Inventor： Ivar M. MCDONALD , Naidu S. CHOWDARI , Walter Lewis Johnson , Yong Zhang , Robert M. BORZILLERI , Sanjeev Gangwar
IPC: A61K47/48 , C07K5/062 , C07D487/04
CPC classification number: C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Abstract translation: 苯并二氮杂二聚体具有由其中X表示的结构，其包含杂芳族部分并且在本申请中进一步定义; R1和式（I），（Ia）和（Ib）中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
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