公开(公告)号：US20230235319A1

公开(公告)日：2023-07-27

申请号：US18009900

申请日：2021-06-09

Applicant: BAYER AKTIENGESELLSCHAFT ,  BAYER CROPSCIENCE LP

Inventor： Philipp Knyphausen ,  Brian Vogler ,  Wayne Coco ,  Andre Cohnen ,  Florian Richter ,  Damian Curtis

IPC: C12N15/10

CPC classification number: C12N15/1082 ,  C12N15/102 ,  C12N15/1055

Abstract: Disclosed are new nucleic acid base-editing systems comprising fusion proteins comprising a) an RNA-programmable nucleic acid recognition module or other suitable nucleic acid recognition module, b) a light inducible reactive oxygen generator. Further disclosed are methods and kits to modify or mutagenize a target DNA region in prokaryotic or eukaryotic cells or organisms.

公开(公告)号：US11406107B2

公开(公告)日：2022-08-09

申请号：US16935020

申请日：2020-07-21

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian Thompson

IPC: A01N63/50 ,  C07K14/325 ,  C12N15/63 ,  C12N15/82 ,  C12N15/866 ,  A01N25/00 ,  A61K38/00 ,  C12N15/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed herein and/or a mutant of a specific strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US20170290339A1

公开(公告)日：2017-10-12

申请号：US15511864

申请日：2015-09-17

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian THOMPSON

IPC: A01N63/00 ,  A01N43/90 ,  A01N47/22 ,  A01N43/22

CPC classification number: A01N63/00 ,  A01N43/22 ,  A01N43/90 ,  A01N47/22 ,  C12Y301/01 ,  C12Y302/01004 ,  C12Y302/01132 ,  Y02A50/356 ,  A01N43/56 ,  A01N47/40 ,  A01N53/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US20240285744A1

公开(公告)日：2024-08-29

申请号：US18644678

申请日：2024-04-24

Applicant: Spogen Biotech Inc. ,  Bayer CropScience LP

Inventor： Damian Curtis ,  Brian Thompson

IPC: A61K39/07 ,  A61K35/00 ,  A61K35/742

CPC classification number: A61K39/07 ,  A61K35/742 ,  C12Y301/01 ,  C12Y302/01004 ,  C12Y302/01132 ,  A61K2035/115 ,  Y02A50/30

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US12005107B2

公开(公告)日：2024-06-11

申请号：US17356941

申请日：2021-06-24

Applicant: Bayer CropScience LP

Inventor： Damian Curtis ,  Brian Thompson

IPC: A61K39/07 ,  A61K35/00 ,  A61K35/742

CPC classification number: A61K39/07 ,  A61K35/742 ,  A61K2035/115

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US11044916B2

公开(公告)日：2021-06-29

申请号：US15511864

申请日：2015-09-17

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian Thompson

IPC: A01N63/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US10988769B2

公开(公告)日：2021-04-27

申请号：US16191964

申请日：2018-11-15

Applicant: Bayer CropScience LP

Inventor： Damian Curtis ,  Benjamin L. Golomb ,  Dilara Ally ,  Florencia A. Ficarra ,  Rauf Salamzade ,  Bjorn A. Traag

IPC: C12N15/74 ,  C12N9/04 ,  C07K14/325 ,  C12N9/24 ,  C12N9/42 ,  A01N63/00 ,  C07K14/195 ,  C12N11/16 ,  C12N15/62 ,  C12N1/20 ,  C12N15/10 ,  A01N63/10

Abstract: Signal sequences useful for targeting proteins and peptides to the surface of endospores produced by Paenibacillus family members and methods of using the same are provided. The display of heterologous molecules, such as peptides, polypeptides and other recombinant constructs, on the spore surface of Paenibacillus family members, using particular N-terminal targeting sequences and derivatives of the same, are also provided.

公开(公告)号：US10897909B2

公开(公告)日：2021-01-26

申请号：US15511864

申请日：2015-09-17

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian Thompson

IPC: A01N63/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.