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公开(公告)号：US11154064B2
公开(公告)日：2021-10-26
申请号：US15511839
申请日：2015-09-17
Applicant: Bayer CropScience LP , Spogen Biotech Inc.
Inventor： Damian Curtis , Brian Thompson
IPC: C07K14/325 , A01N63/00 , A01N25/00 , A61K38/00 , A01N63/50 , C12N15/63 , C12N15/82 , C12N15/866 , C12N15/00
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed herein and/or a mutant of a specific strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US20240316173A1
公开(公告)日：2024-09-26
申请号：US18654255
申请日：2024-05-03
Applicant: Spogen Biotech Inc. , Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
IPC: A61K39/07 , A61K35/00 , A61K35/742
CPC classification number: A61K39/07 , A61K35/742 , A61K2035/115
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US20240285745A1
公开(公告)日：2024-08-29
申请号：US18654243
申请日：2024-05-03
Applicant: Spogen Biotech Inc. , Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
IPC: A61K39/07 , A61K35/00 , A61K35/742
CPC classification number: A61K39/07 , A61K35/742 , A61K2035/115
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US20240285743A1
公开(公告)日：2024-08-29
申请号：US18644663
申请日：2024-04-24
Applicant: Spogen Biotech Inc. , Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
IPC: A61K39/07 , A61K35/00 , A61K35/742
CPC classification number: A61K39/07 , A61K35/742 , C12Y301/01 , C12Y302/01004 , C12Y302/01132 , A61K2035/115 , Y02A50/30
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US12016912B2
公开(公告)日：2024-06-25
申请号：US17356958
申请日：2021-06-24
Applicant: Bayer CropScience LP , Spogen Biotech Inc.
Inventor： Damian Curtis , Brian Thompson
IPC: A61K39/07 , A61K35/00 , A61K35/742
CPC classification number: A61K39/07 , A61K35/742 , C12Y301/01 , C12Y302/01004 , C12Y302/01132 , A61K2035/115 , Y02A50/30 , A01N63/50 , A01N63/22 , A01N63/50 , A01N43/22 , A01N43/56 , A01N43/90 , A01N47/22 , A01N47/40 , A01N53/00
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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Patent Agency Ranking
公开(公告)号：US11044915B2
公开(公告)日：2021-06-29
申请号：US15511835
申请日：2015-09-17
Applicant: Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US11186816B2
公开(公告)日：2021-11-30
申请号：US16245132
申请日：2019-01-10
Applicant: Bayer CropScience LP
Inventor： Varghese P. Thomas , Benjamin L. Golomb , Damian Curtis
Abstract: The disclosure is generally directed to methods for screening, identifying, and producing microorganisms capable of imparting beneficial properties to plants. In some aspects, improved plant-associated soil microorganisms are generated by experimental evolution using a plant root exudate or root exudate compound.
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公开(公告)号：US10897908B2
公开(公告)日：2021-01-26
申请号：US15511835
申请日：2015-09-17
Applicant: Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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公开(公告)号：US09826743B2
公开(公告)日：2017-11-28
申请号：US14857176
申请日：2015-09-17
Applicant: Bayer CropScience LP
Inventor： Damian Curtis , Brian Thompson
Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed herein and/or a mutant of a specific strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.
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10.发明授权公开(公告)号：US11793196B2
公开(公告)日：2023-10-24
申请号：US16822279
申请日：2020-03-18
Applicant: Bayer CropScience LP
Inventor： Damian Curtis , Kevin Bugg
CPC classification number: A01N37/46 , C07K14/32 , C12N9/6424 , C07K2319/00 , C07K2319/035
Abstract: The present invention relates to a fusion protein having a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of a recombinant Bacillus cereus family member and an enzyme having serine protease activity, wherein the enzyme having serine protease activity is from Bacillus firmus or is a variant of such enzyme. The present invention also provides a recombinant Bacillus cereus family member that expresses such fusion protein and exosporium fragments derived from such recombinant Bacillus cereus family member. Methods of using such recombinant Bacillus cereus family members or exosporium fragments derived therefrom for nematode control are also provided.
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