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公开(公告)号：US20200348292A1
公开(公告)日：2020-11-05
申请号：US16095023
申请日：2018-04-23
发明人： Yue GENG , Peizhi CAI , Fengchun PANG , Le GU
IPC分类号： G01N33/543 , G01N21/78 , B01L3/00
摘要： The present disclosure relates to a bio-detection chip and a detection method associated therewith. The bio-detection chip includes an upper substrate, a lower substrate, a reference electrode, a driving electrode, and a first dielectric layer, a first hydrophobic layer, a second hydrophobic layer and a second dielectric layer disposed successively between the reference electrode and the driving electrode. The bio-detection chip further includes a plurality of micro-capsules arranged between the first hydrophobic layer and the second hydrophobic layer. Each micro-capsule encapsulates a plurality of charged microspheres, and surfaces of the charged microspheres have a first biomolecule for specifically binding with a second biomolecule that enters the bio-detection chip so as to give rise to a color change. The charged microspheres move close to the upper substrate when a voltage is applied between the reference electrode and the driving electrode. As such, a result of biomolecule detection may be observed intuitively.
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公开(公告)号：US20200338549A1
公开(公告)日：2020-10-29
申请号：US16768558
申请日：2019-11-13
发明人： Yingying ZHAO , Peizhi CAI , Le GU , Fengchun PANG , Yue GENG , Yuelei XIAO , Haochen CUI , Nan ZHAO , Hui LIAO , Wenliang YAO , Chuncheng CHE
IPC分类号： B01L3/00
摘要： The present disclosure provides a microfluidic chip, including: first base substrate and a second base substrate opposite to each other; first electrode and second electrode between the first base substrate and the second base substrate and configured to control droplet to move between the first base substrate and the second base substrate according to voltages applied on the first electrode and the second electrode; light guide component configured to guide light propagating in the first base substrate to the droplet; shading component and detection component, shading component having light transmission regions spaced from each other, light transmission regions being configured to transmit light passing through the droplet to the detection component, wherein detection component is on second base substrate and is configured to obtain property of the droplet according to an intensity of the light passing through droplet and received from the light transmission regions.
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13.发明申请公开(公告)号：US20200048698A1
公开(公告)日：2020-02-13
申请号：US16486038
申请日：2018-12-24
发明人： Peizhi CAI , Fengchun PANG , Yue GENG , Le GU , Chuncheng CHE
IPC分类号： C12Q1/6869
摘要： A gene sequencing substrate and a method for manufacturing the same, and a gene sequencing device are provided. It belongs to the technical field of gene sequencing, and can solve the problem of high cost of the high-throughput sequencing chip in the prior art. The gene sequencing substrate of the present disclosure comprises a plastic material with concave structures as base substrate, and the concave structures serve as reaction cells. Since the base substrate has plasticity, the concave structures can be formed by a simple process to reduce the cost of the gene sequencing substrate. Meanwhile, a first protective layer may be provided on the inner wall of the concave structures for preventing the inner wall of the concave structures from being corroded by the reaction liquid.
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公开(公告)号：US20190203289A1
公开(公告)日：2019-07-04
申请号：US16325235
申请日：2018-03-30
发明人： Fengchun PANG , Chuncheng CHE , Hailin XUE , Xibin SHAO , Peizhi CAI
IPC分类号： C12Q1/6869 , C12Q1/6837 , B01L3/00 , H01G9/20 , B01J19/02
CPC分类号： C12Q1/6869 , B01J19/02 , B01J2219/00608 , B01L3/5027 , B82Y40/00 , C12Q1/6837 , G01N21/6486 , H01G9/2031
摘要： A gene sequencing chip, a sequencing method thereof and a gene sequencing device are provided. The gene sequencing chip includes: a first substrate having a first surface; at least one recessed portion recessed from the first surface into the first substrate; a graphene oxide layer located at a bottom of the recessed portion; and a first electrode and a second electrode which are electrically connected with the graphene oxide layer. The recessed portion is configured to receive a sample to be tested, and the first electrode and the second electrode are configured to detect a resistance of the graphene oxide layer.
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公开(公告)号：US20190025242A1
公开(公告)日：2019-01-24
申请号：US15752603
申请日：2017-08-18
发明人： Fengchun PANG , Peizhi CAI , Yue GENG
IPC分类号： G01N27/333 , C12Q1/6869 , G01N33/487 , G01N27/327
摘要： The disclosure provides a gene sequencing chip, a gene sequencing apparatus and a gene sequencing method. The gene sequencing chip comprises a substrate; an electrode on the substrate; a signal lead connected with the electrode and configured to input a signal to the electrode and output a signal sensed by the electrode; a first insulation layer on a side of the electrode distal to the substrate; and a baffle, a vertical distance between a surface of the baffle distal to the substrate and the substrate being larger than a vertical distance between a surface of the first insulation layer distal to the substrate and the substrate, and the baffle and the first insulation layer forming a micropore; wherein an orthographic projection of the micropore on the substrate is at least partially overlapped with an orthographic projection of the electrode on the substrate.
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公开(公告)号：US20170153742A1
公开(公告)日：2017-06-01
申请号：US15121897
申请日：2015-11-16
发明人： Fengchun PANG , Lei MA
CPC分类号： G06F3/0416 , G06F3/0412 , G06F3/044 , G09G3/2096 , G09G2310/0286 , G11C19/28
摘要： The present disclosure provides a touch driving circuit for providing driving signals to touch driving electrodes of a touch panel in a touch phase. The touch driving circuit includes a plurality of cascaded touch shift register units. The number of the touch shift register units is same as the number of columns of the touch driving electrodes. The touch driving circuit further includes a plurality of switching units corresponding to the plurality of touch shift register units. The switching unit includes a driving signal input terminal, a control terminal and a driving signal output terminal. When the touch shift register unit outputs a high level signal, the switching unit connects the driving signal input terminal and the driving signal output terminal. Correspondingly, the present disclosure further provides a display device and a driving method thereof.
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公开(公告)号：US20220184577A1
公开(公告)日：2022-06-16
申请号：US17683059
申请日：2022-02-28
发明人： Yue GENG , Fengchun PANG , Peizhi CAI , Le GU
IPC分类号： B01J19/00 , C12Q1/6874
摘要： A gene sequencing chip is provided, which includes: an upper substrate including a plurality of liquid inlets for inletting liquid drops; a lower substrate opposite to the upper substrate and spaced therefrom by a gap, the gap being provided for allowing the liquid drops to move therein, the lower substrate including a liquid drop operation region, the liquid drop operation region including a manipulation electrode array. The manipulation electrode array includes multiple first manipulation electrode array for preparing a gene library, multiple second manipulation electrode array for sequencing the gene library which is prepared, each first sub-array being adjacent to one of the multiple second manipulation electrode array. Based on the gene sequencing chip provided in this disclosure, operations to tiny liquid drops such as movement, fusion and splitting can be accurately manipulated by using digital microfluidic techniques, and all steps of the gene sequencing from library preparation to gene sequencing can be completed on one chip.
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公开(公告)号：US20210181198A1
公开(公告)日：2021-06-17
申请号：US16086322
申请日：2018-02-07
发明人： Fengchun PANG , Chuncheng CHE , Hailin XUE , Xibin SHAO , Peizhi CAI
IPC分类号： G01N33/569 , G01N21/64
摘要： There is provided an influenza virus detection chip and a method for detecting influenza virus therewith. An influenza virus detection chip including: a graphene oxide film; a first pad disposed on one side of the graphene oxide film in a first direction; and a first electrode and a second electrode, connected to both ends of the graphene oxide film in a second direction perpendicular to the first direction, wherein a first monoclonal antibody with a fluorescent label is included in the first pad, and a second monoclonal antibody is included in the graphene oxide film, and wherein the fluorescent label includes a C═C—C═C conjugated double bond.
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公开(公告)号：US20210164032A1
公开(公告)日：2021-06-03
申请号：US16072923
申请日：2017-12-15
发明人： Fengchun PANG , Peizhi CAI , Yue GENG
IPC分类号： C12Q1/6869 , C12Q1/6837
摘要： A chip, a detection system and a gene sequencing method are provided. When the chip is used for gene sequencing, sample genes and reversible terminating nucleotides are added into micropores and matched therein to release hydrogen ions such that a Nernst potential is induced on an ion-sensitive film surface, and a voltage is applied to the transparent electrode layer to generate an electric field, thereby controlling the switching layer to change its state, and then a base type of the genes is determined based on a type of reversible terminating nucleotide corresponding to information of light emitted from the switching layer upon changes in the state of the switching layer, thereby gene sequencing is achieved.
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公开(公告)号：US20210063340A1
公开(公告)日：2021-03-04
申请号：US16632661
申请日：2019-01-02
发明人： Wenliang YAO , Haochen CUI , Peizhi CAI , Fengchun PANG , Yue GENG , Le GU , Nan ZHAO , Yuelei XIAO , Hui LIAO , Yingying ZHAO , Chuncheng CHE
IPC分类号： G01N27/327 , B01L3/00 , H01H29/28
摘要： A chip, a method of operating a chip, and a detection device are provided. The chip includes a detection cavity and a working electrode, the detection cavity is configured to be capable of containing a plurality of droplets, and the working electrode is arranged in the detection cavity and is configured to regularly arrange the plurality of droplets in the detection cavity along an extending direction of the working electrode.
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