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23 条记录 (耗时 0.031 秒)

    METHODS OF TREATMENT USING NOVEL LHRH ANTAGONISTS HAVING IMPROVED SOLUBILITY PROPERTIES
    16.
    发明申请
    METHODS OF TREATMENT USING NOVEL LHRH ANTAGONISTS HAVING IMPROVED SOLUBILITY PROPERTIES 有权
    使用具有改善溶解性的新型LHR拮抗剂治疗方法

    公开(公告)号：US20060281685A1

    公开(公告)日：2006-12-14

    申请号：US11459583

    申请日：2006-07-24

    申请人： Michael Bernd ,  Bernhard Kutscher ,  Eckhard Gunther ,  Peter Romeis ,  Thomas Reissmann ,  Thomas Beckers

    发明人： Michael Bernd ,  Bernhard Kutscher ,  Eckhard Gunther ,  Peter Romeis ,  Thomas Reissmann ,  Thomas Beckers

    IPC分类号： A61K38/10

    CPC分类号： A61K38/10 ,  C07K7/06 ,  C07K7/23

    摘要： The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. The invention also relates methods for treating a hormone-dependent tumor or a non-malignant indication that is treatable by LH-RH suppression, the method comprising administering to a patient in need of the treatment a therapeutically effective amount of a compound of the invention. Hormone-dependent cancers that can be treated with the methods of the invention include prostate cancer, breast cancer, ovarian cancer, endometrial cancer, and pancreatic cancer. Non-malignant indications which can be treated by the methods of the invention include benign prostate hyperplasia (BPH), endometriosis, acne, polycystic ovarian disease, dysmenorrhea, precocious puberty, and uterine fibroids and other leiomyomas.

    摘要翻译： 本发明涉及含有N-甲基化氨基酸单元并具有改善的水溶性的肽。 本发明还涉及用于治疗激素依赖性肿瘤或可通过LH-RH抑制治疗的非恶性指征的方法，所述方法包括向需要治疗的患者施用治疗有效量的本发明化合物。 可用本发明方法治疗的依赖于激素的癌症包括前列腺癌，乳腺癌，卵巢癌，子宫内膜癌和胰腺癌。 可以通过本发明的方法治疗的非恶性适应症包括良性前列腺增生（BPH），子宫内膜异位症，痤疮，多囊卵巢疾病，痛经，早熟性青春期和子宫肌瘤和其他平滑肌瘤。

    Use of perifosine in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
    18.
    发明授权
    Use of perifosine in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals 有权
    使用去糖苷与抗代谢药联合用于治疗人类和哺乳动物的良性和恶性肿瘤

    公开(公告)号：US08551977B2

    公开(公告)日：2013-10-08

    申请号：US12751454

    申请日：2010-03-31

    申请人： Jurgen Engel ,  Eckhard Gunther ,  Herbert Sindermann

    发明人： Jurgen Engel ,  Eckhard Gunther ,  Herbert Sindermann

    IPC分类号： A61K31/70 ,  A61K31/685

    CPC分类号： A61K45/06 ,  A61K31/685 ,  A61K2300/00

    摘要： The invention relates to the use of alkylphosphocholines in combination with antimetabolite antitumor substances for the treatment of benign and malignant oncoses in humans and animals. It is possible in this connection for the alkylphosphocholines to be employed in a combination according to the invention with one or more antimetabolite antitumor substances. Preferred alkylphosphocholines are described by the Formula II. One such preferred alkylphosphocholine is perifosine.

    摘要翻译： 本发明涉及将烷基磷酰胆碱与抗代谢物抗肿瘤物质组合用于治疗人和动物中良性和恶性肿瘤的用途。 在这方面，可以将本发明的组合中的烷基磷酰胆碱与一种或多种抗代谢物抗肿瘤物质一起使用。 优选的烷基磷酰胆碱由式II描述。 一种这样优选的烷基磷酸胆碱是丝胶黄素。