公开(公告)号：US20060292650A1

公开(公告)日：2006-12-28

申请号：US11438902

申请日：2006-05-23

申请人： James Braig ,  Kenneth Witte ,  Margaret Magarian ,  Jane Sheill ,  Bernhard Sterling

发明人： James Braig ,  Kenneth Witte ,  Margaret Magarian ,  Jane Sheill ,  Bernhard Sterling

IPC分类号： C12Q1/54 ,  C12M1/34

CPC分类号： C12Q1/26 ,  C12Q1/32 ,  C12Q1/52 ,  C12Q1/54

摘要： An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed with an optical system at wavelengths that includes at least one wavelength that is sensitive to the analyte concentration and at least one wavelength that is not sensitive to the analyte concentration. The optical system measures properties, such as optical density, and relates the measurements to concentration through a calibration of the system. A method is also provided for analyzing the data obtained from optical measurements of reactions of enzymes with biological fluids. These technologies may be applied to continuous or periodic patient sampling systems or to test strip type devices.

摘要翻译： 提出了使用组合酶分光法估计分析物浓度的装置。 提供葡萄糖和乳酸盐检测的实例。 将生物流体样品与特定于目标分析物的酶混合或接触，并且反应流体用波长包括至少一种对分析物浓度敏感的波长和至少一种波长的光学系统进行探测 对分析物浓度不敏感。 光学系统测量诸如光密度的特性，并通过校准系统将测量值与浓度相关联。 还提供了一种用于分析从酶与生物流体的反应的光学测量获得的数据的方法。 这些技术可以应用于连续或周期性的患者采样系统或测试条型设备。

公开(公告)号：US20050036147A1

公开(公告)日：2005-02-17

申请号：US10825085

申请日：2004-04-15

申请人： Bernhard Sterling ,  James Braig ,  Daniel Goldberger ,  Philip Hartstein ,  Robert Gaffney

发明人： Bernhard Sterling ,  James Braig ,  Daniel Goldberger ,  Philip Hartstein ,  Robert Gaffney

IPC分类号： A61B5/00 ,  G01N21/31 ,  G01N21/35 ,  G01N21/59

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  G01N21/03 ,  G01N21/314 ,  G01N21/35

摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.

摘要翻译： 一种方法确定样品中的分析物浓度。 样品包括分析物和物质。 该方法包括提供样品的吸收数据。 该方法还包括提供该物质的参考吸收数据。 该方法还包括计算吸收数据的物质贡献。 该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

公开(公告)号：US20050197790A1

公开(公告)日：2005-09-08

申请号：US11062110

申请日：2005-02-18

申请人： Bernhard Sterling ,  James Braig ,  Daniel Goldberger ,  Kenneth Witte

发明人： Bernhard Sterling ,  James Braig ,  Daniel Goldberger ,  Kenneth Witte

IPC分类号： A61B5/00 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G01N33/487 ,  G06F19/00 ,  G01N31/00

CPC分类号： A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2562/0295 ,  G01N21/274 ,  G01N21/314 ,  G01N21/35 ,  G01N27/3271

摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.

摘要翻译： 一种方法确定包含分析物和物质的样品中的分析物浓度。 该方法包括提供样品的吸收光谱。 吸收光谱具有吸收基线。 该方法还包括移动吸收光谱，使得吸收基线大约等于所选吸收波长范围内的选定吸收值。 该方法还包括从吸收光谱中减去物质贡献。 因此，该方法提供基本上不含该物质的贡献的校正吸收光谱。

公开(公告)号：US20070106136A1

公开(公告)日：2007-05-10

申请号：US11270241

申请日：2005-11-08

申请人： Bernhard Sterling ,  Alexander Mills

发明人： Bernhard Sterling ,  Alexander Mills

IPC分类号： A61B5/00

CPC分类号： A61B5/14551

摘要： The invention comprises a method and apparatus for processing signals reflecting a physiological characteristic by detecting the intensity of light following tissue absorption at two wavelengths and subtracting the best estimate of the desired signal from the difference between the signals. Corrected first and second intensity signals are determined by applying a residual derived from a combination of the first and second intensity signals as multiplied by a residual factor and subtracted from a difference between the first and second intensity signals to the first and second intensity signals. In one embodiment, the method and apparatus are used to determine arterial oxygen saturation.

摘要翻译： 本发明包括一种用于通过检测在两个波长的组织吸收之后的光的强度来处理反映生理特征的信号的方法和装置，并且从信号之间的差中减去所需信号的最佳估计。 通过将从第一和第二强度信号的组合导出的残差乘以残差因子并从第一和第二强度信号之间的差减去第一和第二强度信号来确定校正的第一和第二强度信号。 在一个实施例中，使用该方法和装置来确定动脉血氧饱和度。

公开(公告)号：US20070104754A1

公开(公告)日：2007-05-10

申请号：US11270397

申请日：2005-11-08

申请人： Bernhard Sterling ,  Alexander Mills

发明人： Bernhard Sterling ,  Alexander Mills

IPC分类号： A61F2/02 ,  A61K9/46

CPC分类号： A61F2/04 ,  A61F2002/044 ,  A61K9/0007 ,  A61K9/0065 ,  A61K9/2086

摘要： The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

摘要翻译： 本发明包括具有外部区域和气体产生材料的胃装置。 胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。 因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。 优选地，胃装置由食品级材料制成。 胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。

公开(公告)号：US20070260132A1

公开(公告)日：2007-11-08

申请号：US11418937

申请日：2006-05-04

申请人： Bernhard Sterling

发明人： Bernhard Sterling

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/00

摘要： The invention comprises a method and apparatus for processing signals reflecting a physiological characteristic by performing an error minimizing mathematical combination between signals from at least two independent sensors. For example, the intensity of light is detected following tissue absorption at two wavelengths and the signals are corrected. Preferably, corrected intensity signals are derived by orthogonal regression. In one embodiment, the method and apparatus are used to determine arterial oxygen saturation.

摘要翻译： 本发明包括一种用于通过执行来自至少两个独立传感器的信号之间的数学组合的误差最小化来处理反映生理特性的信号的方法和装置。 例如，在两个波长的组织吸收之后检测光的强度，并且校正信号。 优选地，通过正交回归导出校正强度信号。 在一个实施例中，使用该方法和装置来确定动脉血氧饱和度。

公开(公告)号：US20070104755A1

公开(公告)日：2007-05-10

申请号：US11270723

申请日：2005-11-08

申请人： Bernhard Sterling ,  Alexander Mills

发明人： Bernhard Sterling ,  Alexander Mills

IPC分类号： A61F2/02

CPC分类号： A61F2/04 ,  A61F5/003 ,  A61F5/0036 ,  A61F2002/044

摘要： The invention comprises a gastric device having a pouch formed from a degradable film. Preferably, the pouch contains a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

摘要翻译： 本发明包括具有由可降解膜形成的袋的胃装置。 优选地，袋包含产气材料。 胃装置中的胃装置在患者的胃中水化，并且气体生成材料将装置扩大到更大的体积。 因此，水合，扩张的胃装置的体积占据胃腔中的空间，并减少患者在达到饱腹感之前摄取的食物量。 优选地，胃装置由食品级材料制成。 胃装置被配置为扩张到期望的体积，然后在停留时间后降解，允许装置通过患者的正常消化过程。