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    Spectroscopic analysis of a biological fluid reacted with an enzyme
    1.
    发明申请
    Spectroscopic analysis of a biological fluid reacted with an enzyme 审中-公开
    与酶反应的生物液体的光谱分析

    公开(公告)号：US20060292650A1

    公开(公告)日：2006-12-28

    申请号：US11438902

    申请日：2006-05-23

    申请人： James Braig ,  Kenneth Witte ,  Margaret Magarian ,  Jane Sheill ,  Bernhard Sterling

    发明人： James Braig ,  Kenneth Witte ,  Margaret Magarian ,  Jane Sheill ,  Bernhard Sterling

    IPC分类号： C12Q1/54 ,  C12M1/34

    CPC分类号： C12Q1/26 ,  C12Q1/32 ,  C12Q1/52 ,  C12Q1/54

    摘要： An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed with an optical system at wavelengths that includes at least one wavelength that is sensitive to the analyte concentration and at least one wavelength that is not sensitive to the analyte concentration. The optical system measures properties, such as optical density, and relates the measurements to concentration through a calibration of the system. A method is also provided for analyzing the data obtained from optical measurements of reactions of enzymes with biological fluids. These technologies may be applied to continuous or periodic patient sampling systems or to test strip type devices.

    摘要翻译： 提出了使用组合酶分光法估计分析物浓度的装置。 提供葡萄糖和乳酸盐检测的实例。 将生物流体样品与特定于目标分析物的酶混合或接触，并且反应流体用波长包括至少一种对分析物浓度敏感的波长和至少一种波长的光学系统进行探测 对分析物浓度不敏感。 光学系统测量诸如光密度的特性，并通过校准系统将测量值与浓度相关联。 还提供了一种用于分析从酶与生物流体的反应的光学测量获得的数据的方法。 这些技术可以应用于连续或周期性的患者采样系统或测试条型设备。

    Analyte detection system for multiple analytes
    2.
    发明申请
    Analyte detection system for multiple analytes 有权
    多种分析物的分析物检测系统

    公开(公告)号：US20060189858A1

    公开(公告)日：2006-08-24

    申请号：US11314176

    申请日：2005-12-21

    申请人： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    发明人： Bernhard Sterling ,  James Braig ,  Kenneth Witte ,  Peter Rule ,  Richard Keenan ,  W. Hall

    IPC分类号： A61B5/00 ,  A61M31/00

    CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

    摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.

    摘要翻译： 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。 在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

    Analyte detection system with interferent identification and correction
    3.
    发明申请
    Analyte detection system with interferent identification and correction 审中-公开
    分析物检测系统具有干扰物识别和校正

    公开(公告)号：US20070103678A1

    公开(公告)日：2007-05-10

    申请号：US11314803

    申请日：2005-12-21

    申请人： Bernhard Sterling ,  W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Richard Keenan ,  Richard King

    发明人： Bernhard Sterling ,  W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Richard Keenan ,  Richard King

    IPC分类号： G01J3/00

    CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

    摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient. The apparatus further comprises a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer configured to obtain spectra from at least a portion of the sample, and a processor in communication with or incorporated into the spectroscopic analyzer. The apparatus further comprises stored program instructions executable by the processor to (a) identify one or more interferents to the measurement of one or more analytes in the bodily fluid as being possibly present in the portion, and (b) reduce errors in the measurement due to the presence of the determined possible interferents. The pump unit can comprise a single dual-mode or reversible pump operable in both the infusion and sample draw modes; or two pumps, one of which is operable in the infusion mode but not in the sample draw mode, and another of which is operable in the sample draw mode but not in the infusion mode.

    摘要翻译： 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端。 该装置还包括与流体处理网络有效接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 该装置还包括分光分析器，被配置为从样品的至少一部分获得光谱，以及与光谱分析仪连通或结合到光谱分析仪中的处理器。 所述装置还包括可由所述处理器执行的存储的程序指令，以（a）识别对所述部分中可能存在的所述体液中的一种或多种分析物的测量的一个或多个干扰物，以及（b）减少所述测量中的误差 确定可能的干扰物的存在。 泵单元可以包括可在输液和抽样模式中操作的单个双模式或可逆泵; 或两个泵，其中一个可在输液模式中操作，但不在样品抽取模式中，另一个在样品抽取模式中可操作，但不在输注模式中。

    Dual measurement analyte detection system
    5.
    发明申请
    Dual measurement analyte detection system 审中-公开
    双测量分析物检测系统

    公开(公告)号：US20050037482A1

    公开(公告)日：2005-02-17

    申请号：US10826006

    申请日：2004-04-15

    申请人： James Braig ,  Peter Rule ,  Kenneth Witte ,  Philip Hartstein ,  Bernhard Sterling

    发明人： James Braig ,  Peter Rule ,  Kenneth Witte ,  Philip Hartstein ,  Bernhard Sterling

    IPC分类号： A61B5/00 ,  C12M1/34

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/14546

    摘要： An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.

    摘要翻译： 分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。 第二分析物的测量可以对第一次测量的定量或定性结果进行调节。 在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。 根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

    Sample element for use in material analysis
    8.
    发明申请
    Sample element for use in material analysis 审中-公开
    用于材料分析的样品元素

    公开(公告)号：US20050106749A1

    公开(公告)日：2005-05-19

    申请号：US10877965

    申请日：2004-06-25

    申请人： James Braig ,  Bernhard Sterling ,  Peter Rule ,  Philip Hartstein ,  Kenneth Li

    发明人： James Braig ,  Bernhard Sterling ,  Peter Rule ,  Philip Hartstein ,  Kenneth Li

    IPC分类号： G01N21/03 ,  G01N21/35 ,  G01N21/86 ,  G01N31/22

    CPC分类号： G01N21/8483 ,  G01N21/0303 ,  G01N21/3577

    摘要： A system and method are provided for determining a concentration of an analyte in a material sample. The method includes providing a sample element with a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. The method further includes employing the sample element with an analyte detection system which determines the concentration of the analyte with clinically acceptable accuracy.

    摘要翻译： 提供了用于确定材料样品中分析物浓度的系统和方法。 所述方法包括提供样品室，所述样品室至少部分地由至少一个窗口形成，所述至少一个窗口由从其入射的电磁辐射的吸收率具有大于约1％波长域的变化的材料形成。 该方法还包括使用样品元件分析物检测系统，其以临床可接受的精度确定分析物的浓度。