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公开(公告)号：US10648465B2
公开(公告)日：2020-05-12
申请号：US15345462
申请日：2016-11-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Nathan Michael Gaskill-Fox , Daniel Nelson Fox
Abstract: Methods and systems for pumping fluid through tubing are provided. Methods include orbiting one or more first rollers at multiple angular speeds around the periphery of a substantially circular first disk having a first radius with each first roller travelling at the same angular speed as the other first rollers, orbiting second rollers at a second angular speed around a substantially circular second disk having substantially the first radius, and increasing the pressure of fluid in tubing between one first roller and one second roller by causing the one or more first rollers to orbit at a first angular speed greater than the second angular speed so the one first roller moves along and fully compresses the tubing in a first section of the first disk, and simultaneously causing the one second roller to move along and fully compress the tubing in a first section of the second disk.
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公开(公告)号：US10508990B2
公开(公告)日：2019-12-17
申请号：US15616712
申请日：2017-06-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Susan Hunter , Nathan Michael Gaskill-Fox , Kevin P. Raley , Richard A. Miles
Abstract: Disclosed is an automated method and apparatus for automatically setting a drop delay period by detecting calibration particles in a waste stream. The drop delay is incremented over a series of drop delays and the number of calibration particles in the waste stream is detected for each drop delay. The drop delay is selected which has the least number of calibration particles in the waste stream.
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公开(公告)号：US20180313742A1
公开(公告)日：2018-11-01
申请号：US16030174
申请日：2018-07-09
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Nathan Michael Gaskill-Fox
IPC: G01N15/14
CPC classification number: G01N15/1404 , G01N1/28 , G01N1/286 , G01N2015/0065 , G01N2015/1006 , G01N2015/1406 , G01N2015/1409 , Y10T137/0324 , Y10T137/7287 , Y10T137/7303 , Y10T137/85978
Abstract: Disclosed is a sheath delivery system that uses a continuous flow of sheath fluid into a pressurized internal reservoir that substantially matches the outflow of sheath fluid through the nozzle of a flow cytometer. A substantially constant level of the sheath fluid is maintained. If the sheath fluid level falls below a desired level, or goes above a desired level, a dampened control system is used to reach the desired level. In addition, air pressure in the pressurized internal container is controlled so that an external sheath container can be removed and refilled with additional sheath fluid without stopping the sheath delivery system 100. Differences in pressure are detected by a droplet camera, which measures the droplet breakoff point to determine the pressure of the sheath fluid in the nozzle.
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Patent Agency Ranking
公开(公告)号：US20180128266A1
公开(公告)日：2018-05-10
申请号：US15345462
申请日：2016-11-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Nathan Michael Gaskill-Fox , Daniel Nelson Fox
CPC classification number: F04B49/20 , F04B11/00 , F04B23/06 , F04B43/0072 , F04B43/1261 , F04B49/065 , F04B49/08 , F04B51/00 , F04B2205/04 , F04B2205/503
Abstract: Methods and systems for pumping fluid through tubing are provided. Methods include orbiting one or more first rollers at multiple angular speeds around the periphery of a substantially circular first disk having a first radius with each first roller travelling at the same angular speed as the other first rollers, orbiting second rollers at a second angular speed around a substantially circular second disk having substantially the first radius, and increasing the pressure of fluid in tubing between one first roller and one second roller by causing the one or more first rollers to orbit at a first angular speed greater than the second angular speed so the one first roller moves along and fully compresses the tubing in a first section of the first disk, and simultaneously causing the one second roller to move along and fully compress the tubing in a first section of the second disk.
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公开(公告)号：US09863864B2
公开(公告)日：2018-01-09
申请号：US15264326
申请日：2016-09-13
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox
CPC classification number: G01N15/1429 , G01N15/1425 , G01N15/147 , G01N2015/1006
Abstract: Disclosed is a threshold selector that selects a threshold by generating a histogram from a detector signal and a flow cytometer. The detector signal includes both data and noise. A histogram is generated, which includes height data from the pulses of the detector signal as well as noise. The flow cytometer can be operated without samples to generate a histogram that includes only noise. The threshold signal can then be selected by selecting an intensity level on the histogram that is between the noise and data.
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公开(公告)号：US20170268998A1
公开(公告)日：2017-09-21
申请号：US15616712
申请日：2017-06-07
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Susan Hunter , Nathan Michael Gaskill-Fox , Kevin P. Raley , Richard A. Miles
CPC classification number: G01N21/64 , G01N15/1012 , G01N15/1427 , G01N15/1459 , G01N2015/1006 , G01N2015/1406 , G01N2015/149
Abstract: Disclosed is an automated method and apparatus for automatically setting a drop delay period by detecting calibration particles in a waste stream. The drop delay is incremented over a series of drop delays and the number of calibration particles in the waste stream is detected for each drop delay. The drop delay is selected which has the least number of calibration particles in the waste stream.
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公开(公告)号：US20170136430A1
公开(公告)日：2017-05-18
申请号：US15417131
申请日：2017-01-26
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Nathan Michael Gaskill-Fox
CPC classification number: G01N15/14 , B01F3/088 , B01F13/0059 , B01F15/0441 , G01N15/1404 , G01N2015/1006 , G01N2015/1409 , G05D11/131
Abstract: Disclosed is a system that can mix deionized water and concentrated sheath fluid to provide sheath fluid in a flow cytometer system having a desired concentration. Flow rates are low, which substantially match the flow rate of sheath fluid through the nozzle, so that turbulence and air bubbles are not formed in the sheath fluid. The available deionized water is then used for back flushing and removal of sample cells and deposited salts from the sheath fluid.
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18.发明申请公开(公告)号：US20170045436A1
公开(公告)日：2017-02-16
申请号：US15234852
申请日：2016-08-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Daniel Nelson Fox , Susan Hunter
CPC classification number: G01N15/1012 , G01N15/1434 , G01N15/1459 , G01N2015/0065 , G01N2015/1006
Abstract: Disclosed is a system and method for characterizing optical filters in a flow cytometer and optionally checking the operation of detectors in the flow cytometer. In some embodiments, the system may utilize an LED board having an opening through which the fluorescence and side scatter beams, rays, or images pass and light emitting diodes around the opening that emit light having different spectral profiles. The different spectral profiles allow the system to identify the optical filters that are placed in the flow cytometer, to verify detector operation, to assist in instrumentation troubleshooting, and to provide a quantitative reference for detector comparison.
Abstract translation: 公开了用于表征流式细胞仪中的滤光器并可选地检查流式细胞仪中的检测器的操作的系统和方法。 在一些实施例中，系统可以利用具有开口的LED板，荧光和侧面散射光束，光线或图像通过该开口，并且围绕开口的发光二极管发射具有不同光谱轮廓的光。 不同的谱分布允许系统识别放置在流式细胞仪中的光学滤波器，以验证检测器操作，以帮助仪器故障排除，并提供用于检测器比较的定量参考。
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