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公开(公告)号：US08968679B2
公开(公告)日：2015-03-03
申请号：US11132996
申请日：2005-05-19
Applicant: Christopher A. Scott , Brian Foley
Inventor： Christopher A. Scott , Brian Foley
IPC: B01L3/00
CPC classification number: B01L3/50255 , B01L3/5085 , B01L2200/025 , B01L2200/0678 , B01L2200/0684 , B01L2200/141 , B01L2300/0681 , B01L2300/0829 , B01L2300/0858
Abstract: A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.
Abstract translation: 包括过滤板和接收板的多孔组件。 每个板包括多个孔，当过滤板与接收板放置成嵌套关系时，每个过滤板井具有相应的容纳板，井中延伸。 接收器板孔具有不均匀的横截面，以便当接收板和过滤板处于嵌套关系时，增加过滤板孔的外壁和对应的接收器板的内壁之间的间隙。 增加的间隙大小减少芯吸和交叉污染。 因此，提供了在上部区域中的最大横截面的多部分井和在下部区域中具有逐渐过渡的区域中的最小化横截面。 本发明的多孔组件还提高了将过滤板和接收板定位成适当的嵌套关系的重复性，并且在处理，混合和摇动操作期间提供了稳定性。
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公开(公告)号：US08075144B2
公开(公告)日：2011-12-13
申请号：US12274581
申请日：2008-11-20
Applicant: William E. Shaw , Michael E DeFlumere , Brian Foley , Walter P. Watson
Inventor： William E. Shaw , Michael E DeFlumere , Brian Foley , Walter P. Watson
IPC: G02B27/00
CPC classification number: G02B17/0652 , G02B23/06
Abstract: A telescope design having an integrated baffle is disclosed herein. The integrated baffle is configured as both a baffle and a mirror support. The integrated baffle can be shaped to the F-cone between the primary and secondary mirrors of a given telescope design. The baffle design can be adjusted to minimize or otherwise reduce the total obscuration of the baffle to improve the optical throughput. The interior facing surfaces of the integrated baffle can be configured with corner reflectors, so that the detector views itself, instead of the baffle.
Abstract translation: 本文公开了具有集成挡板的望远镜设计。 集成挡板被配置为挡板和反射镜支架。 集成挡板可以成形为给定望远镜设计的主镜和副镜之间的F锥。 可以调节挡板设计，以最小化或以其他方式减少挡板的全部遮蔽，从而提高光学通过量。 集成式挡板的内表面可以配有拐角反射器，因此检测器可以自行观察，而不是挡板。
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公开(公告)号：US20060263875A1
公开(公告)日：2006-11-23
申请号：US11132996
申请日：2005-05-19
Applicant: Christopher Scott , Brian Foley
Inventor： Christopher Scott , Brian Foley
CPC classification number: B01L3/50255 , B01L3/5085 , B01L2200/025 , B01L2200/0678 , B01L2200/0684 , B01L2200/141 , B01L2300/0681 , B01L2300/0829 , B01L2300/0858
Abstract: A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.
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公开(公告)号：US07112281B2
公开(公告)日：2006-09-26
申请号：US11289082
申请日：2005-11-29
Applicant: Jeffrey S. Busnach , Brian Foley , Phillip Clark , Joseph E. Gabriels
Inventor： Jeffrey S. Busnach , Brian Foley , Phillip Clark , Joseph E. Gabriels
IPC: B01D29/92
CPC classification number: B01L3/50255 , B01D61/18 , B01D61/20 , B01L2200/0615 , B01L2300/0829 , B01L2400/0406 , B01L2400/049 , G01N2035/00485 , Y10S210/919
Abstract: A device and method for removal of liquid from the downstream side of a membrane or a well, such as a well of a multiwell plate. More specifically, the present invention is directed to a wicking structure, which channels droplets of liquid away from a membrane in communication with a plurality of wells. In the preferred embodiment, the wicking structure is placed in a manifold.
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公开(公告)号：US06953288B2
公开(公告)日：2005-10-11
申请号：US10423145
申请日：2003-04-25
Applicant: Brian Foley , Wolfgang Neuberger , Heinrich Kudla , Stefan Spaniol
Inventor： Brian Foley , Wolfgang Neuberger , Heinrich Kudla , Stefan Spaniol
CPC classification number: G02B6/4292 , G02B2006/4297
Abstract: A safe connection system for coupling radiation from radiation sources, such as lasers, into optical fibers is provided. The system prevents the accidental use of standard optical fibers with radiation sources that require fibers capable of transmitting high power or other radiation with unique characteristics. Because often the fibers for use with high power lasers, for example, may also be used with standard lasers, the system preserves the interchangeability of standard connection systems such as SMA by providing connectors that can properly fit both in standard receptacles and in the receptacles of the present invention. Thus, this connection system preserves the advantages of a standard laser-fiber connection system while increasing the safety of such systems, where it is necessary.
Abstract translation: 提供了用于将辐射源（例如激光器）的辐射耦合到光纤中的安全连接系统。 该系统防止意外使用具有需要能够传输具有独特特性的高功率或其他辐射的光纤的辐射源的标准光纤。 因为通常用于大功率激光器的光纤也可以与标准激光器一起使用，所以该系统通过提供可以适当地适合于标准插座和插座的插座中的标准连接系统（例如SMA）的互换性来保持 本发明。 因此，该连接系统保持标准激光光纤连接系统的优点，同时在需要时增加这种系统的安全性。
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Patent Agency Ranking
公开(公告)号：US20050016916A1
公开(公告)日：2005-01-27
申请号：US10919203
申请日：2004-08-16
Applicant: Thomas Zermani , James Groves , Brian Foley
Inventor： Thomas Zermani , James Groves , Brian Foley
CPC classification number: B01L3/50255 , B01D29/012 , B01D29/05 , B01D29/52 , B01D2201/34 , B01D2201/40 , B01L2200/12 , B01L2300/0829 , Y10S264/48 , Y10T29/49604 , Y10T83/8825
Abstract: The present invention provides a mechanical lock for securing one or more filters within a filtration device and methods for producing the mechanical lock. The use of an interference fit punch causes a portion of the inner surface of the wall to be skived and rolled along the wall until it reaches the desired location where it forms a mechanical crimp to retain the one or more filters within the device. In one embodiment, the inner surface has an inwardly taper. In the other, it has straight walls or outwardly tapered walls. The use of a gasket such as an O-ring on top of the filter before the wall is skived provides a liquid tight seal.
Abstract translation: 本发明提供一种用于将一个或多个过滤器固定在过滤装置内的机械锁和用于产生机械锁的方法。 使用过盈配合冲头使得壁的内表面的一部分沿着壁被切割和滚动，直到其到达期望的位置，在那里它形成机械压接以将一个或多个过滤器保持在装置内。 在一个实施例中，内表面具有向内的锥形。 另一方面，它有直壁或向外的锥形壁。 在壁被切除之前，在过滤器的顶部上使用诸如O形圈的垫圈提供液密密封。
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公开(公告)号：US08758225B2
公开(公告)日：2014-06-24
申请号：US12181248
申请日：2008-07-28
Applicant: Brian Foley , William LeBlanc
Inventor： Brian Foley , William LeBlanc
CPC classification number: A61B1/00137 , A61B1/00121 , A61B1/00128 , A61B1/00133 , A61B18/24
Abstract: An adapter for endoscopic treatments has a fiber constraint device that is set at a desired maximum fiber retraction distance, and provides a physical barrier to prevent excessive fiber retraction into the endoscope. The restricted retraction prevents the fiber from firing within the endoscope, thus avoiding expensive damage to both the endoscope and fiber. This benefits the patient with potentially shorter treatment time and less exposure to anesthesia. The adapter also limits maximum extension of fibers. Limiting maximum extension protects the fiber tip and avoids patient complications. The adapter is securely attached to the optical fiber with a connecting means. When using directionally radiating fiber tips, fiber orientation can be defined and the fiber can be rotated relative to the initial angular position of the fiber tip.
Abstract translation: 用于内窥镜治疗的适配器具有设置在期望的最大光纤回缩距离处的纤维约束装置，并且提供物理屏障以防止过多的纤维缩回到内窥镜中。 限制回缩防止纤维在内窥镜内点燃，从而避免对内窥镜和纤维的昂贵损坏。 这有利于患者治疗时间更短，麻醉时更少。 适配器还限制纤维的最大延伸。 限制最大延伸保护纤维尖端，避免患者并发症。 适配器用连接装置牢固地连接到光纤上。 当使用定向辐射光纤尖端时，可以限定纤维取向并且纤维可以相对于纤维尖端的初始角位置旋转。
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公开(公告)号：USD672457S1
公开(公告)日：2012-12-11
申请号：US29430173
申请日：2012-08-22
Applicant: Brian Foley , XingQuan (Peter) Ren
Designer： Brian Foley , XingQuan (Peter) Ren
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公开(公告)号：US20080300583A1
公开(公告)日：2008-12-04
申请号：US12156508
申请日：2008-06-02
Applicant: Brian Foley
Inventor： Brian Foley
Abstract: An improved device and method for safer and more efficient laser vein treatments are presented. The device includes an optical waveguide optically coupled to a radiation source at its proximal end, having a core, a cladding layer and a tip configured to protect the clad-core, e.g., from contact with collapsing vein walls during laser vein treatment, and to enhance treatment efficiency through improved centering. According to one embodiment, the clad-core is recessed within one or more jacket layers. In some embodiments, the protective jacket on the clad-core may be left on when the jacket layer is added. In embodiments, one or more protective wires are attached to the clad-core or a jacket layer and extend distally past the clad-core. In some such embodiments, three protective wires are substantially equally spaced relative to each other about the circumference of the core, i.e., forming an equilateral triangular pattern. The optical waveguide is useable in conjunction with an introducer structure having protective means to prevent damage to the vein walls, e.g., perforating the vein walls, during insertion of the optical waveguide into the vein. A method of using the device is also disclosed wherein a distal end of the optical waveguide is advanced to a desired position and essentially centered in the vein, and a predetermined wavelength of radiation is output from the distal end of the optical fiber while the optical waveguide is simultaneously withdrawn from the vein.
Abstract translation: 提出了一种更安全，更有效的激光静脉治疗的改进装置和方法。 该装置包括在其近端处光耦合到辐射源的光波导，其具有芯，包覆层和被配置为保护包层芯的尖端，例如在激光静脉治疗期间不与塌陷的静脉壁接触，并且 通过改进中心提高治疗效率。 根据一个实施例，包层芯凹入一个或多个护套层内。 在一些实施例中，当夹套层加入时，包层芯上的保护套可以保持开启。 在实施例中，一个或多个保护线附接到包层芯或护套层并且向远侧延伸穿过包层芯。 在一些这样的实施例中，三条保护线围绕芯的圆周彼此基本相等地间隔开，即形成等边三角形图案。 光波导可以与具有保护装置的导引器结构结合使用，以在将光波导插入静脉期间防止损伤静脉壁，例如穿孔静脉壁。 还公开了使用该装置的方法，其中光波导的远端前进到期望位置并且基本上位于静脉中心，并且预定波长的辐射从光纤的远端输出，而光波导 同时从静脉撤出。
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公开(公告)号：US07357869B2
公开(公告)日：2008-04-15
申请号：US10919203
申请日：2004-08-16
Applicant: Thomas Zermani , James Groves , Brian Foley
Inventor： Thomas Zermani , James Groves , Brian Foley
CPC classification number: B01L3/50255 , B01D29/012 , B01D29/05 , B01D29/52 , B01D2201/34 , B01D2201/40 , B01L2200/12 , B01L2300/0829 , Y10S264/48 , Y10T29/49604 , Y10T83/8825
Abstract: The present invention provides a mechanical lock for securing one or more filters within a filtration device and methods for producing the mechanical lock. The use of an interference fit punch causes a portion of the inner surface of the wall to be skived and rolled along the wall until it reaches the desired location where it forms a mechanical crimp to retain the one or more filters within the device. In one embodiment, the inner surface has an inwardly taper. In the other, it has straight walls or outwardly tapered walls. The use of a gasket such as an O-ring on top of the filter before the wall is skived provides a liquid tight seal.
Abstract translation: 本发明提供一种用于将一个或多个过滤器固定在过滤装置内的机械锁和用于产生机械锁的方法。 使用过盈配合冲头使得壁的内表面的一部分沿着壁被切割和滚动，直到其到达期望的位置，在那里它形成机械压接以将一个或多个过滤器保持在装置内。 在一个实施例中，内表面具有向内的锥形。 另一方面，它有直壁或向外的锥形壁。 在壁被切除之前，在过滤器的顶部上使用诸如O形圈的垫圈提供液密密封。
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