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27 条记录 (耗时 0.048 秒)

    Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
    14.
    发明申请
    Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders 失效
    使用环孢菌素炔/烯类似物来预防或治疗病毒性疾病

    公开(公告)号：US20070232531A1

    公开(公告)日：2007-10-04

    申请号：US11391023

    申请日：2006-03-28

    申请人： Bruce Molino

    发明人： Bruce Molino

    IPC分类号： A61K38/13

    CPC分类号： A61K38/13 ,  A61K38/21 ,  A61K38/212

    摘要： The present invention relates to methods of preventing or treating a mammal with a viral-induced disorder. The method involves administering to the mammal a therapeutically effective amount of a compound represented by Formula I, as shown below: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein, under conditions effective to prevent or treat the viral-induced disorder.

    摘要翻译： 本发明涉及用病毒诱导的病症预防或治疗哺乳动物的方法。 该方法包括向哺乳动物施用治疗有效量的由式I表示的化合物，如下所示：或其药学上可接受的盐，其中X，R 0，R 1， 在本文定义的条件下，在有效预防或治疗病毒诱导的病症的条件下。

    Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
    16.
    发明申请
    Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof 审中-公开

    公开(公告)号：US20060111386A1

    公开(公告)日：2006-05-25

    申请号：US11284330

    申请日：2005-11-21

    申请人： Bruce Molino ,  Barry Berkowitz ,  Marlene Cohen

    发明人： Bruce Molino ,  Barry Berkowitz ,  Marlene Cohen

    IPC分类号： A61K31/4745

    CPC分类号： A61K31/4745

    摘要： The present invention relates to a method of treating disorders including cognition impairment, generalized anxiety disorder, acute stress disorder, social phobia, simple phobias, pre-menstrual dysphoric disorder, social anxiety disorder, major depressive disorder, eating disorders, obesity, anorexia nervosa, bulimia nervosa, binge eating disorder, substance abuse disorders, chemical dependencies, nicotine addiction, cocaine addiction, alcohol addiction, amphetamine addiction, Lesch-Nyhan syndrome, neurodegenerative diseases, late luteal phase syndrome, narcolepsy, psychiatric symptoms anger, rejection sensitivity, movement disorders, extrapyramidal syndrome, Tic disorder, restless leg syndrome, tardive dyskinesia, sleep related eating disorder, night eating syndrome, stress urinary incontinence, migraine, neuropathic pain, diabetic neuropathy, fibromyalgia syndrome, chronic fatigue syndrome, sexual dysfunction, premature ejaculation, and male impotence. This method involves administering to a patient in need of such treatment a therapeutically effective amount of a disclosed compound. Such compounds are 4-phenyl substituted tetrahydroisoquinolines having the Formula IA, IB, IIA, IIB, IIIA or IIIC as set forth herein.

    Use of cyclosporin alkene analogues for preventing or treating viral-induced disorders
    19.
    发明申请
    Use of cyclosporin alkene analogues for preventing or treating viral-induced disorders 审中-公开
    使用环孢菌素烯类似物来预防或治疗病毒性疾病

    公开(公告)号：US20070232532A1

    公开(公告)日：2007-10-04

    申请号：US11391027

    申请日：2006-03-28

    申请人： Bruce Molino

    发明人： Bruce Molino

    IPC分类号： A61K38/13

    CPC分类号： A61K38/13 ,  A61K38/212 ,  A61K2300/00

    摘要： The present invention relates to methods of preventing or treating a mammal with a viral-induced disorder. The method involves administering to the mammal a therapeutically effective amount of a compound represented by Formula I, as shown below: or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein, under conditions effective to prevent or treat the viral-induced disorder.

    摘要翻译： 本发明涉及用病毒诱导的病症预防或治疗哺乳动物的方法。 该方法包括向哺乳动物施用治疗有效量的由式I表示的化合物，如下所示：或其药学上可接受的盐，其中X，R 0，R 1， 在本文定义的条件下，在有效预防或治疗病毒诱导的病症的条件下。