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20 条记录 (耗时 0.018 秒)

    Method and pharmaceutical composition for preventing or treating diseases associated with inflammation
    11.
    发明申请
    Method and pharmaceutical composition for preventing or treating diseases associated with inflammation 审中-公开
    用于预防或治疗与炎症有关的疾病的方法和药物组合物

    公开(公告)号：US20090035314A1

    公开(公告)日：2009-02-05

    申请号：US11665195

    申请日：2005-10-12

    申请人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung

    发明人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung

    IPC分类号： A61K39/395 ,  A61K38/02 ,  A61K38/16 ,  C12Q1/02 ,  A61P29/00 ,  A61K31/7052

    CPC分类号： A61K38/17 ,  A61K2039/505 ,  C07K16/18 ,  Y02A50/40

    摘要： The present invention relates to a method and pharmaceutical composition for preventing or treating inflammatory diseases. More particularly, the present invention relates to a method for inhibiting lymphocyte adhesion to an endothelial cell, or a method for treating an inflammatory disease, which comprises administering to a subject in need thereof an inhibitor against lymphocyte adhesion to a FEX-2 polypeptide. A pharmaceutical composition comprising the inhibitor against lymphocyte adhesion to a FEX-2 polypeptide, and the use of the inhibitor against lymphocyte adhesion to a FEX-2 polypeptide are also disclosed. Further, a method for screening a medicament for inhibiting lymphocyte adhesion to a FEX-2 polypeptide or a medicament for treating an inflammatory disease, which comprises a step of selecting an inhibitor against lymphocyte adhesion to a FEX-2 polypeptide, is disclosed.

    摘要翻译： 本发明涉及一种预防或治疗炎性疾病的方法和药物组合物。 更具体地说，本发明涉及抑制淋巴细胞对内皮细胞粘附的方法或治疗炎症性疾病的方法，其包括向有需要的受试者施用抑制淋巴细胞粘附于FEX-2多肽的抑制剂。 还公开了包含抗FEX-2多肽的淋巴细胞粘附抑制剂的药物组合物，以及使用该抗体对淋巴细胞粘附于FEX-2多肽的用途。 此外，公开了一种筛选用于抑制对FEX-2多肽的淋巴细胞粘附的药物或用于治疗炎性疾病的药物的方法，其包括选择抗FEX-2多肽的淋巴细胞粘附抑制剂的步骤。

    Peptides and Derivatives Thereof Showing Cell Attachment, Spreading and Detachment Activity
    12.
    发明申请
    Peptides and Derivatives Thereof Showing Cell Attachment, Spreading and Detachment Activity 审中-公开
    肽及其衍生物显示细胞附着，扩散和分离活性

    公开(公告)号：US20080015150A1

    公开(公告)日：2008-01-17

    申请号：US11777245

    申请日：2007-07-12

    申请人： In-San Kim ,  Jung-Eun Kim

    发明人： In-San Kim ,  Jung-Eun Kim

    IPC分类号： A61K38/00

    CPC分类号： A61K38/08 ,  C07K7/06 ,  C07K14/4718 ,  C07K14/78

    摘要： The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL and EPDIM and derivatives thereof which promote the cell attachment activity through interaction with α 3β 1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing β ig-h3, wound healing, tissue regeneration and metastasis inhibition.

    摘要翻译： 本发明涉及具有细胞附着，扩散和分离活性的肽及其衍生物。 特别地，本发明涉及通过与作为功能性细胞受体的α3β1整联蛋白相互作用而促进细胞附着活性的肽NKDIL和EPDIM及其衍生物，并且包括对于细胞附着和分离活性至关重要的天冬氨酸和异亮氨酸。 本发明的肽及其衍生物可用于开发通过含有βig-h3的各种细胞外基质蛋白，伤口愈合，组织再生和转移抑制介导的细胞附着活性的研究。

    Method for measuring the amount of betaig-h3 protein and diagnostic kit using the same
    13.
    发明申请
    Method for measuring the amount of betaig-h3 protein and diagnostic kit using the same 审中-公开
    用于测量βig-h3蛋白量的方法及使用其的诊断试剂盒

    公开(公告)号：US20050164197A1

    公开(公告)日：2005-07-28

    申请号：US10511719

    申请日：2002-10-22

    申请人： In-San Kim ,  Jong-Sub Bae

    发明人： In-San Kim ,  Jong-Sub Bae

    IPC分类号： G01N33/53 ,  C07K14/705 ,  C12N15/09 ,  G01N33/566 ,  G01N33/68 ,  G01N37/00 ,  C12Q1/68

    CPC分类号： G01N33/6887 ,  G01N2333/78

    摘要： The present invention relates to the method for measuring the amount of βig-h3 protein and diagnostic kit using the same. Particularly, it relates to the method for measuring the amount of βig-h3 protein in the body fluids by specific binding reaction between βig-h3 protein or recombinant proteins of fas-1 domain in the βig-h3 protein (including their fragments or their derivatives) and their ligands and relates to diagnostic kit for the renal diseases, hepatic diseases, rheumatoid arthritis or cardiovascular diseases comprising βig-h3 protein or recombinant proteins of fas-1 domain in the βig-h3 protein (including their fragments or their derivatives) and their ligands. The method and kit of the present invention can be effectively used as sensitive diagnostic method for the extent of damage or progress of the renal diseases, hepatic diseases, rheumatoid arthritis or cardiovascular diseases.

    摘要翻译： 本发明涉及测量βGG-3蛋白的量的方法及使用其的诊断试剂盒。 特别涉及通过beta-h3蛋白或β-h3蛋白（包括其片段或衍生物）中fas-1结构域的重组蛋白之间的特异性结合反应来测量体液中β-h3蛋白的量的方法 ）及其配体，涉及包含betaig-h3蛋白或β-h3蛋白（包括其片段或其衍生物）中fas-1结构域的重组蛋白的肾脏疾病，肝脏疾病，类风湿性关节炎或心血管疾病的诊断试剂盒，以及 它们的配体。 本发明的方法和试剂盒可以有效地用作肾脏疾病，肝脏疾病，类风湿性关节炎或心血管疾病的损伤或进展程度的敏感诊断方法。

    NOVEL USE OF LIGANDS SPECIFIC TO FEX-2 POLYPEPTIDE
    14.
    发明申请
    NOVEL USE OF LIGANDS SPECIFIC TO FEX-2 POLYPEPTIDE 审中-公开
    使用FEX-2多肽特异性配体的新用途

    公开(公告)号：US20090028871A1

    公开(公告)日：2009-01-29

    申请号：US11665190

    申请日：2005-10-12

    申请人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung ,  Ha-Jeong Kim

    发明人： In-San Kim ,  Seung-Yeon Park ,  Mi-Yeon Jung ,  Ha-Jeong Kim

    IPC分类号： A61K39/395 ,  A61K31/661 ,  G01N33/53 ,  A61P37/06

    CPC分类号： A61K31/685 ,  Y02A50/40

    摘要： The present invention relates to novel use of a ligand specific to a FEX-2 polypeptide. More specifically, the present invention relates to methods for modulating the secretion of an inflammation-associated cytokine and for treating or preventing an inflammatory disease using the FEX-2-specific ligand. The ligand specific to the FEX-2 polypeptide can bind to FEX-2 expressed on the surface of phagocytes so that it can stimulate the secretion of anti-inflammatory cytokine and inhibit the secretion of inflammatory cytokine, so as to treat or prevent inflammatory diseases.

    摘要翻译： 本发明涉及FEX-2多肽特异性配体的新用途。 更具体地，本发明涉及用于调节炎症相关细胞因子的分泌以及使用FEX-2特异性配体治疗或预防炎性疾病的方法。 对FEX-2多肽特异性的配体可以结合在吞噬细胞表面上表达的FEX-2，从而可以刺激抗炎细胞因子的分泌并抑制炎性细胞因子的分泌，从而治疗或预防炎性疾病。

    Bone-filling composition for stimulating bone-forming and bone-consolidation comprising calcium sulfate and viscous biopolymers
    16.
    发明申请
    Bone-filling composition for stimulating bone-forming and bone-consolidation comprising calcium sulfate and viscous biopolymers 失效
    用于刺激骨形成和骨固化的骨填充组合物，其包含硫酸钙和粘性生物聚合物

    公开(公告)号：US20060165799A1

    公开(公告)日：2006-07-27

    申请号：US10528749

    申请日：2002-09-30

    申请人： In-San Kim ,  Byung Cho

    发明人： In-San Kim ,  Byung Cho

    IPC分类号： A61K33/06 ,  A61K9/14

    CPC分类号： A61K33/06 ,  A61K33/10 ,  A61L27/446 ,  A61L2430/02 ,  A61K2300/00

    摘要： The present invention relates to a composition for bone-filling, more particularly, to a bone-filling composition for stimulating bone-formation and bone consolidation comprising calcium sulfate and viscous biopolymers. The composition of the present invention can easily be administered into the missing part of injured bone. Since the composition of the present invention does not diffuse to surrounding organs, it can effectively be used for bone-filling material suitable for body.

    摘要翻译： 本发明涉及一种用于骨填充的组合物，更具体地涉及一种用于刺激骨形成和骨固定的骨填充组合物，其包含硫酸钙和粘性生物聚合物。 本发明的组合物可以容易地施用于受损骨的缺损部分。 由于本发明的组合物不会扩散到周围的器官，所以可以有效地用于适合身体的骨填充材料。

    Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof
    18.
    发明授权
    Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof 失效
    形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法

    公开(公告)号：US07511023B2

    公开(公告)日：2009-03-31

    申请号：US10473629

    申请日：2002-08-14

    申请人： Ick Chan Kwon ,  In-San Kim ,  Seo Young Jeong ,  Hesson Chung ,  Yong Woo Cho ,  Yoen Ju Son ,  Chong Rae Park ,  Sang Bong Seo

    发明人： Ick Chan Kwon ,  In-San Kim ,  Seo Young Jeong ,  Hesson Chung ,  Yong Woo Cho ,  Yoen Ju Son ,  Chong Rae Park ,  Sang Bong Seo

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K31/704 ,  A61K47/61 ,  A61K47/6907

    摘要： The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer drug-chitosan complex forming self-aggregates in aqueous media composed of a hydrophobic anticancer agent and a hydrophilic chitosan, and the preparation method thereof. The anticancer drug-chitosan complex of the present invention not only works selectively against target tumor tissue but also continues to release the medicine over a long period of time. Besides, the anticancer drug-chitosan complex could have greater amount of drug by adding the anticancer drug into self-aggregates, which is generally limited by chemical bond. Therefore, the anticancer drug-chitosan complex of the present invention can be effectively used for the cancer chemotherapy.

    摘要翻译： 本发明涉及形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法。 更准确地说，本发明涉及在由疏水性抗癌剂和亲水性壳聚糖组成的水性介质中形成自聚集体的抗癌药物 - 壳聚糖复合物及其制备方法。 本发明的抗癌药物 - 壳聚糖复合物不仅对目标肿瘤组织有选择性的作用，而且还能够长时间地释放药物。 此外，抗癌药物 - 壳聚糖复合物可以通过将抗癌药物加入自聚集体中而具有更大量的药物，其通常受化学键的限制。 因此，本发明的抗癌药物 - 壳聚糖复合物可以有效地用于癌症化疗。

    Imidazole derivative, process for producing the same, and use
    19.
    发明申请
    Imidazole derivative, process for producing the same, and use 有权
    咪唑衍生物，其制备方法及用途

    公开(公告)号：US20070004622A1

    公开(公告)日：2007-01-04

    申请号：US10552291

    申请日：2004-04-02

    申请人： Ju-Ock Nam ,  Jung-Eun Kim ,  Ha-Won Jeong ,  Sung-Jin Lee ,  Byung-Heong Lee ,  Je-Yong Choi ,  Rang-Woon Park ,  Jae-Yong Park ,  In-San Kim

    发明人： Ju-Ock Nam ,  Jung-Eun Kim ,  Ha-Won Jeong ,  Sung-Jin Lee ,  Byung-Heong Lee ,  Je-Yong Choi ,  Rang-Woon Park ,  Jae-Yong Park ,  In-San Kim

    IPC分类号： A61K38/17

    CPC分类号： A61K38/10

    摘要： The present invention relates to the use of a peptide that interacts with the αvβ3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a peptide consisting of at least 18 amino acids, comprising tyrosine-histidine (TY) or asparagines-histidine (NH), and at least three hydrophobic amino acids with bulky side chains; or equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the peptide.

    摘要翻译： 本发明涉及与内皮细胞的alphavbeta3整联蛋白相互作用的肽的用途。 更具体地，本发明涉及使用由至少18个氨基酸组成的包含酪氨酸 - 组氨酸（TY）或天冬酰胺 - 组氨酸（NH）的肽来抑制内皮细胞粘附，内皮细胞迁移和/或血管生成的方法，以及 至少三个具有庞大侧链的疏水性氨基酸; 或其等同物。 此外，本发明提供了使用肽治疗或预防血管生成相关疾病的方法。

    Peptides and derivatives thereof showing cell attachment, spreading and detachment activity
    20.
    发明授权
    Peptides and derivatives thereof showing cell attachment, spreading and detachment activity 失效
    肽及其衍生物显示细胞附着，扩散和分离活性

    公开(公告)号：US07070956B2

    公开(公告)日：2006-07-04

    申请号：US10276601

    申请日：2000-12-06

    申请人： In-San Kim ,  Jung-Eun Kim

    发明人： In-San Kim ,  Jung-Eun Kim

    IPC分类号： C12P21/06 ,  C12N15/00 ,  C12N5/00 ,  C07K1/00 ,  C07K14/00

    CPC分类号： A61K38/08 ,  C07K7/06 ,  C07K14/4718 ,  C07K14/78

    摘要： The present invention relates to peptides and derivatives thereof showing cell attachment, spreading and detachment activity. Particularly, the present invention relates to the peptide NKDIL and EPDIM and derivatives thereof which promote the cell attachment activity through interaction with a α 3β 1 integrin as a functional cell receptor and include aspartic acid and isoleucine essential for cell attachment and detachment activity. The peptides and derivatives thereof in the present invention can be used for developing a study of cell attachment activity mediated through various extracellular matrix protein containing β ig-h3, wound healing, tissue regeneration and metastasis inhibition.

    摘要翻译： 本发明涉及具有细胞附着，扩散和分离活性的肽及其衍生物。 特别地，本发明涉及通过与作为功能性细胞受体的α3β1整联蛋白相互作用而促进细胞附着活性的肽NKDIL和EPDIM及其衍生物，并且包括对于细胞附着和分离活性必需的天冬氨酸和异亮氨酸。 本发明的肽及其衍生物可用于开发通过含有βig-h3的各种细胞外基质蛋白，伤口愈合，组织再生和转移抑制介导的细胞附着活性的研究。