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公开(公告)号：US06613567B1
公开(公告)日：2003-09-02
申请号：US09663834
申请日：2000-09-15
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2102
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Her-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-2. Methods of using these compounds for modulation of Her-2 expression and for treatment of diseases associated with expression of Her-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节Her-2的表达。 组合物包含靶向编码Her-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节Her-2表达和治疗与Her-2表达相关的疾病的方法。
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公开(公告)号：US06426220B1
公开(公告)日：2002-07-30
申请号：US09702327
申请日：2000-10-30
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of calreticulin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding calreticulin. Methods of using these compounds for modulation of calreticulin expression and for treatment of diseases associated with expression of calreticulin are provided.
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公开(公告)号：US06335194B1
公开(公告)日：2002-01-01
申请号：US09496694
申请日：2000-02-02
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C07B2200/11 , C07H21/00 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节存活蛋白的表达。 组合物包含靶向编码存活蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活蛋白表达相关的疾病的方法。
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公开(公告)号：US06200807B1
公开(公告)日：2001-03-13
申请号：US09358683
申请日：1999-07-21
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2102
CPC分类号： C12N15/1137 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of SHP-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SHP-2. Methods of using these compounds for modulation of SHP-2 expression and for treatment of diseases associated with expression of SHP-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节SHP-2的表达。 组合物包含靶向编码SHP-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节SHP-2表达和治疗与SHP-2表达相关的疾病的方法。
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公开(公告)号：US6037176A
公开(公告)日：2000-03-14
申请号：US344520
申请日：1999-06-25
申请人： C. Frank Bennett , Brett P. Monia , Lex M. Cowsert
发明人： C. Frank Bennett , Brett P. Monia , Lex M. Cowsert
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of integrin beta 3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin beta 3. Methods of using these compounds for modulation of integrin beta 3 expression and for treatment of diseases associated with expression of integrin beta 3 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节整联蛋白β3的表达。该组合物包含靶向编码整联蛋白β3的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节整联蛋白β3表达和 提供了与整合素β3表达相关的疾病的治疗。
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公开(公告)号：US5958772A
公开(公告)日：1999-09-28
申请号：US205204
申请日：1998-12-03
IPC分类号： C12N15/09 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P43/00 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/316 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Cellular Inhibitor of Apoptosis-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Cellular Inhibitor of Apoptosis-1. Methods of using these compounds for modulation of Cellular Inhibitor of Apoptosis-1 expression and for treatment of diseases associated with expression of Cellular Inhibitor of Apoptosis-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节细胞凋亡抑制剂-1的表达。 组合物包含靶向编码细胞凋亡抑制剂-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节细胞凋亡-1表达的细胞抑制剂和用于治疗与凋亡细胞抑制剂-1的表达相关的疾病的方法。
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公开(公告)号：US07700574B2
公开(公告)日：2010-04-20
申请号：US10944274
申请日：2004-09-17
申请人： Brenda F Baker , C. Frank Bennett , Kenneth W. Dobie , Kathleen Myers , Joshua Finger , Lex M. Cowsert
发明人： Brenda F Baker , C. Frank Bennett , Kenneth W. Dobie , Kathleen Myers , Joshua Finger , Lex M. Cowsert
IPC分类号： A01N43/04
CPC分类号： C07H21/02 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/345
摘要： Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.
摘要翻译： 提供化合物，组合物和方法用于调节RANKL的表达。 组合物包含针对编码RANKL的核酸的寡核苷酸。 提供了使用这些化合物调节RANKL表达和用于诊断和治疗与RANKL表达相关的疾病的方法。
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公开(公告)号：US06656688B1
公开(公告)日：2003-12-02
申请号：US09856747
申请日：2001-05-24
申请人： C. Frank Bennett , Brett P. Monia , Lex M. Cowsert
发明人： C. Frank Bennett , Brett P. Monia , Lex M. Cowsert
IPC分类号： C07H2100
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of NF-kappa-B p65 subunit. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding NF-kappa-B p65 subunit. Methods of using these compounds for modulation of NF-kappa-B p65 subunit expression and for treatment of diseases associated with expression of NF-kappa-B p65 subunit are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节NF-κBp65亚基的表达。 组合物包含靶向编码NF-κBp65亚基的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节NF-κBp65亚基表达和治疗与NF-κBp65亚基表达相关的疾病的方法。
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公开(公告)号：US06255111B1
公开(公告)日：2001-07-03
申请号：US09632580
申请日：2000-07-31
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Her-4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-4. Methods of using these compounds for modulation of Her-4 expression and for treatment of diseases associated with expression of Her-4 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节Her-4的表达。 组合物包含靶向编码Her-4的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节Her-4表达和治疗与Her-4表达相关的疾病的方法。
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公开(公告)号：US6156571A
公开(公告)日：2000-12-05
申请号：US440612
申请日：1999-11-15
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P5/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07H21/00 , C12N15/113 , C12Q1/02 , C12Q1/68 , C12N15/85 , C07H21/04
CPC分类号： C12N15/1137 , C07H21/00 , C12Y203/01048 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of SRC-3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SRC-3. Methods of using these compounds for modulation of SRC-3 expression and for treatment of diseases associated with expression of SRC-3 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节SRC-3的表达。 组合物包含靶向编码SRC-3的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节SRC-3表达和治疗与SRC-3表达相关的疾病的方法。
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