公开(公告)号：US11653910B2

公开(公告)日：2023-05-23

申请号：US17875589

申请日：2022-07-28

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen ,  Yossi Gross ,  Tal Reich

IPC: A61B17/04 ,  A61F2/24 ,  A61B17/00

CPC classification number: A61B17/0401 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2457 ,  A61B2017/00243 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61F2/243 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2466 ,  A61F2220/0016 ,  A61F2230/005 ,  A61F2230/0041

Abstract: A transluminal sheath is advanced transseptally into a left atrium of the subject. A distal end of a surrounding-sheath, having an anchor disposed therein, is advanced via a distal end of the transluminal sheath, into a left ventricle of the subject via a commissure of the mitral valve. While the distal end of the surrounding-sheath is in the left ventricle, the surrounding-sheath is pulled proximally with respect to the anchor to expose the anchor. While the distal end of the surrounding-sheath is in the left ventricle, mitral valve tissue that is within the left ventricle is encircled by helically wrapping the anchor around the mitral valve tissue. Subsequently, the surrounding-sheath is extracted from the heart. Other embodiments are also described.

公开(公告)号：US11291547B2

公开(公告)日：2022-04-05

申请号：US17335845

申请日：2021-06-01

Applicant: CARDIOVALVE LTD.

Inventor： Yossi Gross ,  Gil Hacohen

IPC: A61F2/24 ,  A61B17/122 ,  A61B17/00 ,  A61F2/848

Abstract: An implant is coupled to first and second native leaflets of a native heart valve of a patient. The implant includes a proximal collar, a distal collar, and first and second clasps. Each of the clasps has first and second tissue-engaging portions that are (1) disposed distal to the proximal collar and proximal to the distal collar, and (2) movable, with respect to each other, to clamp one of the leaflets between the tissue-engaging portions of the clasp. The implant is configured such that, when the leaflets are clamped by the clasps, the clasps form the first and second native leaflets into a double orifice, each orifice configured to function as a respective check-valve. Fabric extends distally from the proximal collar on either side of the central longitudinal axis, and is coupled to the clasps. Other embodiments are also described.

公开(公告)号：US11291546B2

公开(公告)日：2022-04-05

申请号：US17306231

申请日：2021-05-03

Applicant: CARDIOVALVE LTD.

Inventor： Yossi Gross ,  Gil Hacohen

IPC: A61F2/24 ,  A61B17/122 ,  A61B17/00 ,  A61F2/848

Abstract: An implant is configured to be coupled to first and second native leaflets of a native heart valve of a patient. The implant includes a proximal collar, a distal collar, and first and second clasps. Each of the first and second clasps has first and second tissue-engaging portions that are (1) disposed distal to the proximal collar and proximal to the distal collar, (2) movable, with respect to each other, to clamp one of the leaflets between the first and second tissue-engaging portions of the clasp, and (3) movable, when clamped to the leaflet, toward and away from a central longitudinal axis of the implant. The implant includes fabric (i) extending distally from the proximal collar on either side of the central longitudinal axis, and (ii) coupled to the first and second clasps. Other embodiments are also described.

公开(公告)号：US11109964B2

公开(公告)日：2021-09-07

申请号：US16138129

申请日：2018-09-21

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen

IPC: A61F2/24 ,  A61B17/04 ,  A61B17/064 ,  A61B17/00

Abstract: A catheter is transluminally advanced to a heart of a subject. Via the catheter, a prosthetic valve is advanced to the native valve. The prosthetic valve includes an upstream skirt, and a downstream skirt that has a first portion and a second portion. The first portion defines a lumen therethrough. The second portion circumscribes the first portion, and defines a plurality of anchoring arms that are coupled to the second portion. A plurality of prosthetic leaflets, within the lumen, are attached to the first portion. The upstream skirt is expanded in the atrium, and the anchoring arms are expanded in the ventricle, the anchoring arms extending radially outward and toward the upstream skirt. Subsequently, native valve tissue is squeezed between the upstream skirt and the anchoring arms by causing the anchoring arms to move with respect to the prosthetic leaflets, and toward the upstream skirt.

公开(公告)号：US10702385B2

公开(公告)日：2020-07-07

申请号：US16284331

申请日：2019-02-25

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen

IPC: A61F2/24 ,  A61F2/848

Abstract: A native heart valve includes a first leaflet and a second leaflet. The first and second leaflets are arranged into a double-orifice by using the implant to couple a middle scallop of the first leaflet to a middle scallop of the second leaflet. Using at least one clip controller, each clip is opened by deflecting an arm of the clip away from a midline of the implant, and each clip is closed by deflecting the arm of the clip back toward the midline. The first and second clips are opened and closed independently of each other. Other embodiments are also described.

公开(公告)号：US10548726B2

公开(公告)日：2020-02-04

申请号：US16388038

申请日：2019-04-18

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen

IPC: A61F2/24

Abstract: A prosthetic valve structure, in a collapsed state thereof, is transcatheterally advanced toward a native valve of a subject, the native valve including native leaflets, and the prosthetic valve structure including prosthetic leaflets. An annular portion of the prosthetic valve structure is positioned between the native leaflets. Subsequently, the prosthetic valve structure is rotated such that curved anchors of the prosthetic valve structure gather the native chordae tendineae of the heart between the anchors and the annular portion.

公开(公告)号：US10231831B2

公开(公告)日：2019-03-19

申请号：US15188507

申请日：2016-06-21

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen

IPC: A61F2/24

Abstract: Apparatus and methods are provided for use with a prosthetic valve that is designated for implantation at a patient's native heart valve, including a valve ring having a plurality of ring segments, each of the segments being hingedly coupled to an adjacent segment at a pivot joint. The valve ring is placed adjacent to a surface of the native heart valve, the prosthetic valve having been coupled to the valve ring. In an expanded state thereof, the valve ring defines a ring, all of the pivot joints being disposed in a plane that is perpendicular to a longitudinal axis of the ring. The valve ring is foldable into a shape that has a generally circular cross-section that defines and surrounds at least in part a central lumen, by folding the segments with respect to each other, at the pivot joints. Other embodiments are also described.

公开(公告)号：US11951005B2

公开(公告)日：2024-04-09

申请号：US18218419

申请日：2023-07-05

Applicant: CARDIOVALVE LTD.

Inventor： Yossi Gross ,  Gil Hacohen

IPC: A61F2/24 ,  A61B17/122 ,  A61B17/00 ,  A61F2/848

CPC classification number: A61F2/2418 ,  A61B17/122 ,  A61F2/2409 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/2454 ,  A61F2/246 ,  A61F2/2466 ,  A61B2017/00243 ,  A61F2/2427 ,  A61F2/2433 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2/2463 ,  A61F2/848 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0091 ,  A61F2230/0006 ,  A61F2230/0013 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/0015 ,  A61F2250/006 ,  A61F2250/0069 ,  A61F2250/0071

Abstract: A heart valve repair system includes a delivery sheath and an implant that includes a frame including a braided structure of intertwining strands and having a surface configured to contact an upstream surface of a native heart valve. First and second gripping members are coupled to the frame, each including atrial and ventricular arms. The implant is disposed in the sheath in a delivery state in which the frame defines a wall fully surrounding a central longitudinal axis of the implant. The distal end of the wall defines a distal opening of the frame. The distal end of the wall is disposed proximally to the second end of the ventricular arm of each of the gripping members. The second end of each ventricular arm moves toward the axis of the implant more than the first end moves toward the axis. Other embodiments are also described.

公开(公告)号：US20240050227A1

公开(公告)日：2024-02-15

申请号：US18384139

申请日：2023-10-26

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2/2457

Abstract: Apparatus and methods are provided for use with a prosthetic valve that is designated for implantation at a patient's native heart valve, including a valve ring having a plurality of ring segments, each of the segments being hingedly coupled to an adjacent segment at a pivot joint. The valve ring is placed adjacent to a surface of the native heart valve, the prosthetic valve having been coupled to the valve ring. In an expanded state thereof, the valve ring defines a ring, all of the pivot joints being disposed in a plane that is perpendicular to a longitudinal axis of the ring. The valve ring is foldable into a shape that has a generally circular cross-section that defines and surrounds at least in part a central lumen, by folding the segments with respect to each other, at the pivot joints. Other embodiments are also described.

公开(公告)号：US11517429B2

公开(公告)日：2022-12-06

申请号：US17473472

申请日：2021-09-13

Applicant: CARDIOVALVE LTD.

Inventor： Yossi Gross ,  Gil Hacohen

IPC: A61F2/24 ,  A61F2/848

Abstract: A system includes a core and a catheter for use with (A) a first atrial arm and a first ventricular arm articulatable with respect to each other at a first articulation site to clamp one leaflet of a patient's native heart valve, and (B) a second atrial arm and a second ventricular arm articulatable with respect to each other at a second articulation site to clamp another native leaflet of the native valve. The core tapers in a distal direction toward its smallest perimeter, defining a minimum nonzero angle of the atrial arms with respect to a central longitudinal axis of the core. The catheter advances the core and the arms toward the native valve. The catheter and the core have an advancement configuration in which the smallest perimeter of the core is adjacent to the first and second articulation sites. Other embodiments are also described.