公开(公告)号：US11555198B2

公开(公告)日：2023-01-17

申请号：US14439420

申请日：2013-10-31

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H1/06 ,  C12N15/82 ,  C12N15/01 ,  C12N9/22 ,  C12P21/00

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

公开(公告)号：US10513698B2

公开(公告)日：2019-12-24

申请号：US14653604

申请日：2013-12-20

Applicant: CELLECTIS

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Feng Zhang ,  Benjamin Clasen ,  William Haun ,  Thomas Stoddard

IPC: C12N15/01 ,  C12N15/82 ,  A01H6/82

Abstract: Materials and methods are provided for making Solanum varieties with decreased accumulation of reducing sugars and acrylamide in cold-stored potatoes, specifically, by making TALE-nuclease-induced mutations in genes encoding vacuolar invertase.

公开(公告)号：US20160222395A1

公开(公告)日：2016-08-04

申请号：US15013323

申请日：2016-02-02

Applicant: CELLECTIS

Inventor： Thomas Stoddard ,  Nicholas J. Baltes ,  Song Luo

IPC: C12N15/82

CPC classification number: C12N15/8205 ,  C12N15/8213 ,  C12N15/8245 ,  C12N15/8251 ,  C12N15/8282

Abstract: Methods for genome engineering, including methods utilizing transient expression of a nuclease utilizing modified transfer-DNA (T-DNA) plasmids, are provided herein.

Abstract translation: 本文提供了基因组工程方法，包括利用修饰的转移DNA（T-DNA）质粒瞬时表达核酸酶的方法。

公开(公告)号：US20160145631A1

公开(公告)日：2016-05-26

申请号：US14898208

申请日：2014-06-13

Applicant: CELLECTIS

Inventor： Daniel F. Voytas ,  Feng Zhang ,  Jin Li ,  Thomas Stoddard ,  Song Luo

IPC: C12N15/82 ,  C12N9/22

CPC classification number: C12N15/8206 ,  C12N9/22 ,  C12N15/8207 ,  C12N15/8213

Abstract: Materials and methods for creating genome-engineered plants with non-transgenic methods are provided herein.

Abstract translation: 本文提供了用非转基因方法产生基因组工程植物的材料和方法。

公开(公告)号：US20140120578A1

公开(公告)日：2014-05-01

申请号：US14068731

申请日：2013-10-31

Applicant: Medicago Inc. ,  Cellectis SA

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-André D'Aoust

IPC: C12N15/82 ,  C12N15/01 ,  C12P21/00

Abstract: Materials and Methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Abstract translation: 提供材料和方法用于制备适于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。