公开(公告)号：US20210059142A1

公开(公告)日：2021-03-04

申请号：US17098210

申请日：2020-11-13

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H1/06 ,  C12N15/82 ,  C12N15/01 ,  C12N9/22 ,  C12P21/00

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

公开(公告)号：US20150272076A1

公开(公告)日：2015-10-01

申请号：US14439420

申请日：2013-10-31

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H5/12 ,  A01H1/06 ,  C12P21/00

CPC classification number: A01H5/12 ,  A01H1/06 ,  C12N9/22 ,  C12N15/01 ,  C12N15/8218 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12P21/005

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Abstract translation: 提供材料和方法用于制造适合于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。

公开(公告)号：US20150291967A1

公开(公告)日：2015-10-15

申请号：US14439413

申请日：2013-10-31

Applicant: Luc MATHIS ,  Daniel VOYTAS ,  Jin LI ,  Feng ZHANG ,  Song LUO ,  CELLECTIS

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Song Luo

IPC: C12N15/82

CPC classification number: C12N15/8213 ,  C12N15/8209 ,  C12N15/8274 ,  C12N15/8278

Abstract: The present invention relates to methods allowing the targeted insertion of transgenes into a plant genome at desired loci by using homologous recombination combined with rare-cutting endonucleases without the need of inserting an exogenous selectable marker.

Abstract translation: 本发明涉及通过使用与稀有切割内切核酸酶组合的同源重组而不需要插入外源选择性标记的方法，允许将转基因靶向插入到所需基因座的植物基因组中。

公开(公告)号：US20210002656A1

公开(公告)日：2021-01-07

申请号：US17022421

申请日：2020-09-16

Applicant: CELLECTIS

Inventor： Daniel F. Voytas ,  Feng Zhang ,  Jin Li ,  Thomas Stoddard ,  Song Luo

IPC: C12N15/82 ,  C12N9/22

Abstract: Materials and methods for creating genome-engineered plants with non-transgenic methods are provided herein.

公开(公告)号：US11576317B2

公开(公告)日：2023-02-14

申请号：US17098210

申请日：2020-11-13

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H1/06 ,  A01H6/82 ,  A01H5/12 ,  C12N15/82 ,  C12N15/01 ,  C12N9/22 ,  C12P21/00

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

公开(公告)号：US11555198B2

公开(公告)日：2023-01-17

申请号：US14439420

申请日：2013-10-31

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H1/06 ,  C12N15/82 ,  C12N15/01 ,  C12N9/22 ,  C12P21/00

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

公开(公告)号：US20160145631A1

公开(公告)日：2016-05-26

申请号：US14898208

申请日：2014-06-13

Applicant: CELLECTIS

Inventor： Daniel F. Voytas ,  Feng Zhang ,  Jin Li ,  Thomas Stoddard ,  Song Luo

IPC: C12N15/82 ,  C12N9/22

CPC classification number: C12N15/8206 ,  C12N9/22 ,  C12N15/8207 ,  C12N15/8213

Abstract: Materials and methods for creating genome-engineered plants with non-transgenic methods are provided herein.

Abstract translation: 本文提供了用非转基因方法产生基因组工程植物的材料和方法。

公开(公告)号：US20140120578A1

公开(公告)日：2014-05-01

申请号：US14068731

申请日：2013-10-31

Applicant: Medicago Inc. ,  Cellectis SA

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-André D'Aoust

IPC: C12N15/82 ,  C12N15/01 ,  C12P21/00

Abstract: Materials and Methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Abstract translation: 提供材料和方法用于制备适于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。