公开(公告)号：US20160068535A1

公开(公告)日：2016-03-10

申请号：US14944668

申请日：2015-11-18

Applicant: Cephalon, Inc.

Inventor： Ralph C. Haltiwanger ,  Eugen F. Mesaros ,  Gregory R. Ott

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: This application provides compounds of the general formula (I) and/or a salt thereof, where X, R1 and R2 are as defined herein. Compositions and therapeutic uses are also described.

Abstract translation: 本申请提供了通式（I）和/或其盐的化合物，其中X，R 1和R 2如本文所定义。 还描述了组合物和治疗用途。

公开(公告)号：US20150374693A1

公开(公告)日：2015-12-31

申请号：US14824750

申请日：2015-08-12

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506

CPC classification number: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本发明提供式（I）化合物或其盐形式。 式（I）化合物具有ALK和FAK抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US20140350011A1

公开(公告)日：2014-11-27

申请号：US14446411

申请日：2014-07-30

Applicant: Cephalon, Inc.

Inventor： Henry J. Breslin ,  Matthew A. Curry ,  Diane E. Gingrich ,  Keith S. Learn ,  Gregory R. Ott ,  Jason C. Wagner

IPC: C07D493/08 ,  C07D491/107 ,  C07D471/04

CPC classification number: C07D493/08 ,  C07D471/04 ,  C07D491/107

Abstract: This application relates to compounds of the Formula I as defined herein, and/or salts thereof. This application further relates to compositions and methods of using these compounds and/or salts thereof. The compounds of Formula I are useful as ALK and JAK modulators for the treatment of proliferative disorders.

Abstract translation: 本申请涉及本文定义的式I化合物和/或其盐。 本申请还涉及使用这些化合物和/或其盐的组合物和方法。 式I的化合物可用作治疗增殖性疾病的ALK和JAK调节剂。

公开(公告)号：US20190328735A1

公开(公告)日：2019-10-31

申请号：US16172368

申请日：2018-10-26

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506 ,  C07D403/04

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

公开(公告)号：US20190308934A1

公开(公告)日：2019-10-10

申请号：US16449612

申请日：2019-06-24

Applicant: CEPHALON, INC.

Inventor： Ralph Laufer ,  Gregory R. Ott

IPC: C07C271/22 ,  C07C233/05 ,  C07C271/28 ,  C07C305/12 ,  C07D207/09 ,  C07D223/16 ,  C07D263/18 ,  C07F9/09 ,  A61K31/165 ,  A61K31/18 ,  A61K31/196 ,  A61K31/198 ,  A61K31/216 ,  A61K31/24 ,  A61K31/255 ,  A61K31/325 ,  A61K31/40 ,  A61K31/421 ,  A61K31/55 ,  A61K31/661 ,  A61K31/7028 ,  A61K38/03 ,  C07K4/00 ,  C07C233/36 ,  C07D207/08 ,  C07H13/04 ,  C07D223/12 ,  C07C237/20 ,  C07C233/54 ,  C07C233/51 ,  C07C229/42 ,  C07C311/51 ,  C07C233/47

Abstract: The present disclosure relates to prodrugs of 7-chlorokynurenic acid. In certain embodiments, the prodrugs include those having the structure of any one of formula (I)-(VIII), wherein R1-R13, monomer 1, monomer 2, and linker are defined herein. Also provided are methods of preparing and using these prodrugs.

公开(公告)号：US20170027948A1

公开(公告)日：2017-02-02

申请号：US15292468

申请日：2016-10-13

Applicant: Cephalon, Inc.

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Gregory R. Ott

IPC: A61K31/529 ,  A61K31/5377

CPC classification number: A61K31/529 ,  A61K31/5377 ,  C07D487/08 ,  C07D487/18

Abstract: The present invention provides compounds of Formula I or a pharmaceutically acceptable salt forms thereof, wherein R1, R2, R3, R4, R5, A and X are as defined herein, methods of treatment and uses thereof.

Abstract translation: 或其药学上可接受的盐形式，其中R 1，R 2，R 3，R 4，R 5，A和X如本文所定义，其处理方法及其用途。

公开(公告)号：US20160347756A1

公开(公告)日：2016-12-01

申请号：US15232084

申请日：2016-08-09

Applicant: Cephalon, Inc.

Inventor： Ralph C. Haltiwanger ,  Eugen F. Mesaros ,  Gregory R. Ott

IPC: C07D487/04

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: This application provides compounds of the general formula (I) and/or a salt thereof, where X, R1 and R2 are as defined herein. Compositions and therapeutic uses are also described.

Abstract translation: 和/或其盐，其中X，R 1和R 2如本文所定义。 还描述了组合物和治疗用途。

公开(公告)号：US20160243119A1

公开(公告)日：2016-08-25

申请号：US15146164

申请日：2016-05-04

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier (deceased) ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506

CPC classification number: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本发明提供式（I）化合物或其盐形式。 式（I）化合物具有ALK和FAK抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US20140323435A1

公开(公告)日：2014-10-30

申请号：US14285007

申请日：2014-05-22

Applicant: Cancer Research Technology Limited ,  Cephalon, Inc.

Inventor： Bruce D. Dorsey ,  Keith S. Learn ,  Emma L. Morris ,  Gregory R. Ott ,  Jonathan R.A. Roffey ,  Christelle N. Soudy ,  Jason C. Wagner

IPC: C07D495/04 ,  C07D495/20 ,  C07F7/08 ,  C07D495/14

CPC classification number: C07D495/04 ,  C07D495/14 ,  C07D495/20 ,  C07D519/00 ,  C07F7/0812

Abstract: The present application provides a compound of formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, R6, A, G, M, Q and X are as defined herein. A compound of formula (I) and its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本申请提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4，R 5，R 6，A，G，M，Q和X如本文所定义。 式（I）化合物及其盐具有PKC抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US20140031351A1

公开(公告)日：2014-01-30

申请号：US14025986

申请日：2013-09-13

Applicant: Cephalon, Inc.

Inventor： Henry J. Breslin ,  Bruce D. Dorsey ,  Gregory R. Ott

IPC: C07D487/08

CPC classification number: A61K31/529 ,  A61K31/5377 ,  C07D487/08 ,  C07D487/18

Abstract: The present invention provides compounds of Formula I or a pharmaceutically acceptable salt forms thereof, wherein R1, R2, R3, R4, R5, A and X are as defined herein, methods of treatment and uses thereof.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐形式，其中R 1，R 2，R 3，R 4，R 5，A和X如本文所定义，其处理方法及其用途。