公开(公告)号：US20230227447A1

公开(公告)日：2023-07-20

申请号：US17927762

申请日：2021-05-24

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Anna KARAWAJCZYK ,  Bartosz Pawel GUT

IPC: C07D471/04 ,  C07D487/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D213/81 ,  C07D239/26 ,  C07D519/00 ,  C07D213/74 ,  C07D401/04

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D417/12 ,  C07D403/12 ,  C07D401/12 ,  C07D239/42 ,  C07D213/81 ,  C07D239/26 ,  C07D519/00 ,  C07D213/74 ,  C07D401/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting DDR1 and DDR2, particularly the invention relates to compounds that are benzylamine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.

公开(公告)号：US20170158694A1

公开(公告)日：2017-06-08

申请号：US15364669

申请日：2016-11-30

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Ian LINNEY

IPC: C07D471/08 ,  C07D401/12 ,  A61K31/4704 ,  C07D409/12 ,  C07D409/14 ,  A61K45/06 ,  C07D405/14

CPC classification number: C07D471/08 ,  A61K31/4704 ,  A61K31/4709 ,  A61K45/06 ,  C07D401/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14

Abstract: Compounds of formula (I), defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.

公开(公告)号：US20170152256A1

公开(公告)日：2017-06-01

申请号：US15316401

申请日：2014-06-04

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mauro RICCABONI ,  Andrea RIZZI ,  Charles BAKER-GLENN ,  Wesley BLACKABY ,  Herve VAN DE POEL ,  Ben WHITTAKER

IPC: C07D453/02

CPC classification number: C07D453/02 ,  C07D453/00

Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

公开(公告)号：US20160235734A1

公开(公告)日：2016-08-18

申请号：US15040382

申请日：2016-02-10

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Fabio RANCATI ,  Andrea RIZZI ,  Laura CARZANIGA ,  Ian LINNEY ,  Chris KNIGHT ,  Wolfgang SCHMIDT

IPC: A61K31/4704 ,  A61K9/00 ,  C07D401/12 ,  A61K31/4709 ,  C07D409/14 ,  C07D498/10 ,  C07D215/227 ,  C07D401/14 ,  A61K31/496 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  A61K45/06 ,  C07D453/02

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/5386 ,  A61K45/06 ,  C07D215/227 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D453/02 ,  C07D453/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.

Abstract translation: 式I定义的化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于治疗支气管阻塞性和炎性疾病。