公开(公告)号：US20130289010A1

公开(公告)日：2013-10-31

申请号：US13930304

申请日：2013-06-28

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Gabriele AMARI ,  Elisabetta Armani ,  Maurizio Delcanale

IPC: C07D213/30 ,  A61K31/44 ,  A61K45/06 ,  C07D213/89

CPC classification number: A61M15/0065 ,  A61K31/44 ,  A61K31/4704 ,  A61K45/06 ,  A61M16/14 ,  C07D213/30 ,  C07D213/61 ,  C07D213/89

Abstract: 1-Phenyl-2-pyridinyl alkyl alcohol compounds are effective as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and may be used to prevent and/or treat certain diseases or conditions.

Abstract translation: 1-苯基-2-吡啶基烷基醇化合物作为磷酸二酯酶4（PDE4）酶的抑制剂是有效的，可用于预防和/或治疗某些疾病或病症。

公开(公告)号：US20130172302A1

公开(公告)日：2013-07-04

申请号：US13729388

申请日：2012-12-28

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Gabriele AMARI ,  Cristina Pesenti ,  Stefano Bossolo

IPC: C07D453/02 ,  A61K45/06 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/496 ,  A61K31/439 ,  A61K31/56

CPC classification number: C07D453/02 ,  A61K31/439 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/56 ,  A61K45/06 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds of formula (I): wherein A, R1, R2, X, m, and n are as defined in the specification, are selective M3 receptor antagonists and may be used in the treatment of, inter alia, a respiratory disease such as asthma and COPD.

Abstract translation: 式（I）化合物：其中A，R 1，R 2，X，m和n如说明书中所定义，是选择性M3受体拮抗剂，并且可用于治疗尤其是呼吸道疾病如哮喘 和COPD。

公开(公告)号：US20230063121A1

公开(公告)日：2023-03-02

申请号：US17784557

申请日：2020-12-10

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mafalda PAGANO ,  Luca RAVEGLIA ,  Marta GIULIANI ,  Claudia BEATO

IPC: C07D417/12 ,  C07D239/94 ,  C07D413/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/14

Abstract: The present invention relates to a compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

公开(公告)号：US20230043672A1

公开(公告)日：2023-02-09

申请号：US17784539

申请日：2020-12-10

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mafalda PAGANO ,  Luca RAVEGLIA ,  Claudia BEATO

IPC: C07D417/14 ,  C07D417/12

Abstract: The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are aromatic amido derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

公开(公告)号：US20170152256A1

公开(公告)日：2017-06-01

申请号：US15316401

申请日：2014-06-04

Applicant: Chiesi Farmaceutici S.p.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mauro RICCABONI ,  Andrea RIZZI ,  Charles BAKER-GLENN ,  Wesley BLACKABY ,  Herve VAN DE POEL ,  Ben WHITTAKER

IPC: C07D453/02

CPC classification number: C07D453/02 ,  C07D453/00

Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

公开(公告)号：US20160346260A1

公开(公告)日：2016-12-01

申请号：US15168438

申请日：2016-05-31

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Herve VAN DE POEOL ,  Charles BAKER-GLENN ,  Naimisha TRIVEDI

IPC: A61K31/444 ,  A61K31/452 ,  C07D453/02 ,  C07D401/12

CPC classification number: A61K31/444 ,  A61K31/452 ,  C07D401/12 ,  C07D453/02

Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.

Abstract translation: 本文定义的式（I）化合物均为磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，可用于治疗呼吸道疾病。

公开(公告)号：US20150158858A1

公开(公告)日：2015-06-11

申请号：US14560140

申请日：2014-12-04

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Eleonora GHIDINI ,  Charles BAKER-GLENN ,  Hervé VAN DE POËL ,  Ben WHITTAKER

IPC: C07D453/02 ,  C07D409/14 ,  A61M15/00 ,  A61K31/4545 ,  A61K31/4436 ,  A61M16/14 ,  A61K31/444 ,  A61K31/4439

CPC classification number: C07D453/02 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61M15/0065 ,  A61M16/14 ,  A61M2202/064 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds of formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 本文所述的式（I）化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。

公开(公告)号：US20150158857A1

公开(公告)日：2015-06-11

申请号：US14560009

申请日：2014-12-04

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Gabriele AMARI ,  Elisabetta Armani ,  Carmelida Capaldi ,  Renato De Fanti ,  Mauro Riccaboni ,  Charles Baker-Glenn ,  Hervé Van De Poël

IPC: C07D453/02 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/444

CPC classification number: C07D453/02 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: Compounds having a benzhydryl structure represented by formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.

Abstract translation: 具有本文所述的式（I）表示的二苯甲基结构的化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，并且可用于治疗呼吸道疾病。