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    SYSTEMS AND METHODS FOR OCULAR DRUG DELIVERY
    12.
    发明申请
    SYSTEMS AND METHODS FOR OCULAR DRUG DELIVERY 审中-公开

    公开(公告)号：US20190307606A1

    公开(公告)日：2019-10-10

    申请号：US16178162

    申请日：2018-11-01

    Applicant: CLEARSIDE BIOMEDICAL, INC.

    Inventor： Rafael Victor ANDINO ,  Thomas Edward GODFREY ,  Shelley Eckert HANCOCK ,  Samirkumar PATEL ,  Keleigh Jo MAHN ,  Jesse YOO ,  Vladimir ZARNITSYN

    IPC: A61F9/00 ,  A61K9/00

    Abstract: Devices, methods, and kits for ocular drug delivery are described herein. An apparatus can include a housing, an energy storage member, a barrel, and a hub. The housing contains the energy storage member. A proximal end portion of the barrel is coupled to a distal end portion of the housing. The barrel is configured to contain medicament and includes at least a portion of a piston and an elastomeric member. The piston is configured to move the elastomeric member within the barrel in response to a force produced by the energy storage member. The hub is coupled to a distal end portion of the barrel. An inner surface of the hub defines a nozzle through which the medicament flows when the elastomeric member moves within the barrel. The nozzle and the energy storage member are collectively configured to produce a fluid jet to access a target location within an eye.

    APPARATUS AND METHODS FOR OCULAR INJECTION
    16.
    发明申请
    APPARATUS AND METHODS FOR OCULAR INJECTION 有权
    装置和注射方法

    公开(公告)号：US20150038905A1

    公开(公告)日：2015-02-05

    申请号：US14268687

    申请日：2014-05-02

    Applicant: Clearside Biomedical, Inc.

    Inventor： Rafael Victor ANDINO ,  Vladimir ZARNITSYN ,  Christopher John BROOKS

    IPC: A61M5/46 ,  A61M5/34

    CPC classification number: A61F9/0017 ,  A61F2250/0007 ,  A61F2250/0069 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2096 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/31 ,  A61M5/3293 ,  A61M5/34 ,  A61M5/344 ,  A61M5/346 ,  A61M5/347 ,  A61M5/348 ,  A61M5/349 ,  A61M5/46 ,  A61M5/482 ,  A61M37/0015 ,  A61M2005/31508 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/0612

    Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

    Abstract translation: 一种装置包括联接到药物容器的壳体，其联接到针上。 注射组件设置在壳体内并且包括能量存储构件和致动杆。 致动杆的远端部分设置在药物容器内。 能量存储构件可以在致动杆的近端部分上产生足以将致动杆的远端部分移动到药物容器内的力。 当针的远端设置在目标位置的第一区域内时，这可以经由针从药物容器中传送至少一部分物质。 当针的远端设置在目标位置的第二区域内时，力不足以将致动杆的远端部分移动到药物容器内。

    FORMULATIONS AND METHODS FOR REDUCTION OF INTRAOCULAR PRESSURE
    20.
    发明申请
    FORMULATIONS AND METHODS FOR REDUCTION OF INTRAOCULAR PRESSURE 审中-公开

    公开(公告)号：US20190133933A1

    公开(公告)日：2019-05-09

    申请号：US16097303

    申请日：2017-05-01

    Applicant: CLEARSIDE BIOMEDICAL, INC.

    Inventor： Richard BECKMAN ,  Jesse YOO ,  Rafael Victor ANDINO ,  Glenn NORONHA ,  Samirkumar PATEL ,  Donna TARABORELLI ,  Vladimir ZARNITSYN

    IPC: A61K9/00 ,  A61K47/36 ,  A61F9/00 ,  A61F9/007 ,  A61M37/00

    Abstract: The current disclosure relates to formulations and methods for reducing intraocular pressure (IOP) in the eye of a subject in need thereof. The disclosure also relates to formulations and methods for reducing intraocular pressure (IOP) related to glaucoma in a subject. The methods provided include non-surgically administering a non-pharmacologically active injectable formulation to the eye of the subject by using an apparatus that is suitable for delivering the formulations. The methods provided also include placing a solid implant into the eye of the subject to create a controlled space in the suprachoroidal space (SCS) or the supraciliary space of the eye of the subject in need thereof. The present disclosure further comprises facilitating and improving the aqueous outflows in the eye through the trabecular meshwork outflow pathway and/or uveoscleral outflow pathway and thereby decreasing the intraocular pressure.

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