公开(公告)号：US20200030143A1

公开(公告)日：2020-01-30

申请号：US16591067

申请日：2019-10-02

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor ANDINO ,  Vladimir ZARNITSYN ,  Jesse YOO ,  Christopher John BROOKS ,  Trent John KAHUTE ,  Justin William ARSENAULT ,  David Jackson TRETTIN ,  Andrew Kent BAUER ,  Stephanie Elaine LEWIS

IPC: A61F9/00 ,  A61J1/20 ,  A61M5/34 ,  A61M5/31 ,  A61M37/00 ,  A61M5/20 ,  A61M5/32 ,  A61M5/48 ,  A61M5/46

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20180028358A1

公开(公告)日：2018-02-01

申请号：US15714441

申请日：2017-09-25

Applicant: Clearside Biomedical, Inc.

Inventor： Rafael Victor ANDINO ,  Vladimir ZARNITSYN ,  Jesse YOO ,  Christopher John BROOKS ,  Trent John KAHUTE ,  Justin William ARSENAULT ,  David Jackson TRETTIN ,  Andrew Kent BAUER ,  Stephanie Elaine LEWIS

IPC: A61F9/00 ,  A61M5/20 ,  A61M37/00 ,  A61M5/34 ,  A61M5/46 ,  A61M5/48 ,  A61J1/20 ,  A61M5/32

CPC classification number: A61F9/0017 ,  A61F2250/0007 ,  A61F2250/0069 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2096 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/31 ,  A61M5/3293 ,  A61M5/34 ,  A61M5/344 ,  A61M5/346 ,  A61M5/347 ,  A61M5/348 ,  A61M5/349 ,  A61M5/46 ,  A61M5/482 ,  A61M37/0015 ,  A61M2005/31508 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/0612

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20190290485A1

公开(公告)日：2019-09-26

申请号：US16440108

申请日：2019-06-13

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor ANDINO ,  Thomas Edward GODFREY ,  Shelley Eckert HANCOCK ,  Samirkumar PATEL ,  Keleigh Jo STRUDTHOFF ,  Jesse YOO ,  Vladimir ZARNITSYN

IPC: A61F9/00 ,  A61K38/18 ,  A61K45/06 ,  A61K38/39 ,  A61K38/36

Abstract: Devices, methods, and kits for ocular drug delivery are described herein. In some embodiments, a method includes inserting a distal end portion of a puncture member into an eye to define a delivery passageway within the eye. The delivery passageway extends through ha sclera of the eye and a choroid of the eye. The delivery passageway is less than about 1.5 mm. The method further includes conveying a substance into a subretinal space within the eye via the distal end portion of the puncture member.

公开(公告)号：US20170112665A1

公开(公告)日：2017-04-27

申请号：US15399239

申请日：2017-01-05

Applicant: Clearside Biomedical, Inc.

Inventor： Rafael Victor ANDINO ,  Vladimir ZARNITSYN ,  Jesse YOO ,  Christopher John BROOKS ,  Trent John KAHUTE ,  Justin William ARSENAULT ,  David Jackson TRETTIN ,  Andrew Kent BAUER ,  Stephanie Elaine LEWIS

IPC: A61F9/00 ,  A61M5/20 ,  A61M5/48 ,  A61M5/32 ,  A61M5/46 ,  A61M37/00 ,  A61J1/20

CPC classification number: A61F9/0017 ,  A61F2250/0007 ,  A61F2250/0069 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2096 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/31 ,  A61M5/3293 ,  A61M5/34 ,  A61M5/344 ,  A61M5/346 ,  A61M5/347 ,  A61M5/348 ,  A61M5/349 ,  A61M5/46 ,  A61M5/482 ,  A61M37/0015 ,  A61M2005/31508 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/0612

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20190307606A1

公开(公告)日：2019-10-10

申请号：US16178162

申请日：2018-11-01

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor ANDINO ,  Thomas Edward GODFREY ,  Shelley Eckert HANCOCK ,  Samirkumar PATEL ,  Keleigh Jo MAHN ,  Jesse YOO ,  Vladimir ZARNITSYN

IPC: A61F9/00 ,  A61K9/00

Abstract: Devices, methods, and kits for ocular drug delivery are described herein. An apparatus can include a housing, an energy storage member, a barrel, and a hub. The housing contains the energy storage member. A proximal end portion of the barrel is coupled to a distal end portion of the housing. The barrel is configured to contain medicament and includes at least a portion of a piston and an elastomeric member. The piston is configured to move the elastomeric member within the barrel in response to a force produced by the energy storage member. The hub is coupled to a distal end portion of the barrel. An inner surface of the hub defines a nozzle through which the medicament flows when the elastomeric member moves within the barrel. The nozzle and the energy storage member are collectively configured to produce a fluid jet to access a target location within an eye.

公开(公告)号：US20180333297A1

公开(公告)日：2018-11-22

申请号：US15946838

申请日：2018-04-06

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor ANDINO ,  Vladimir ZARNITSYN ,  Jesse YOO ,  Christopher John BROOKS ,  Trent John KAHUTE ,  Justin William ARSENAULT ,  David Jackson TRETTIN ,  Andrew Kent BAUER ,  Stephanie Elaine LEWIS

IPC: A61F9/00 ,  A61M5/32 ,  A61M5/31 ,  A61J1/20 ,  A61M5/48 ,  A61M5/20 ,  A61M5/34 ,  A61M5/46

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20150051581A1

公开(公告)日：2015-02-19

申请号：US14523243

申请日：2014-10-24

Applicant: Clearside Biomedical, Inc.

Inventor： Rafael Victor ANDINO ,  Vladimir ZARNITSYN ,  Christopher John BROOKS ,  Jesse YOO

IPC: A61F9/00 ,  A61M37/00

CPC classification number: A61F9/0017 ,  A61F2250/0007 ,  A61F2250/0069 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2096 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/31 ,  A61M5/3293 ,  A61M5/34 ,  A61M5/344 ,  A61M5/346 ,  A61M5/347 ,  A61M5/348 ,  A61M5/349 ,  A61M5/46 ,  A61M5/482 ,  A61M37/0015 ,  A61M2005/31508 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/0612

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20190350755A1

公开(公告)日：2019-11-21

申请号：US16510238

申请日：2019-07-12

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor ANDINO ,  Vladimir ZARNITSYN ,  Jesse YOO ,  Christopher John BROOKS ,  Trent John KAHUTE ,  Justin William ARSENAULT ,  David Jackson TRETTIN ,  Andrew Kent BAUER ,  Stephanie Elaine LEWIS

IPC: A61F9/00 ,  A61M5/32 ,  A61M5/34 ,  A61M37/00 ,  A61M5/31 ,  A61J1/20 ,  A61M5/48 ,  A61M5/20 ,  A61M5/46

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20190231592A1

公开(公告)日：2019-08-01

申请号：US16381213

申请日：2019-04-11

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor ANDINO ,  Vladimir ZARNITSYN ,  Jesse YOO ,  Christopher John BROOKS ,  Trent John KAHUTE ,  Justin William ARSENAULT ,  David Jackson TRETTIN ,  Andrew Kent BAUER ,  Stephanie Elaine LEWIS

IPC: A61F9/00 ,  A61M5/32 ,  A61M5/34 ,  A61M37/00 ,  A61M5/31 ,  A61J1/20 ,  A61M5/48 ,  A61M5/20 ,  A61M5/46

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20190133933A1

公开(公告)日：2019-05-09

申请号：US16097303

申请日：2017-05-01

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Richard BECKMAN ,  Jesse YOO ,  Rafael Victor ANDINO ,  Glenn NORONHA ,  Samirkumar PATEL ,  Donna TARABORELLI ,  Vladimir ZARNITSYN

IPC: A61K9/00 ,  A61K47/36 ,  A61F9/00 ,  A61F9/007 ,  A61M37/00

Abstract: The current disclosure relates to formulations and methods for reducing intraocular pressure (IOP) in the eye of a subject in need thereof. The disclosure also relates to formulations and methods for reducing intraocular pressure (IOP) related to glaucoma in a subject. The methods provided include non-surgically administering a non-pharmacologically active injectable formulation to the eye of the subject by using an apparatus that is suitable for delivering the formulations. The methods provided also include placing a solid implant into the eye of the subject to create a controlled space in the suprachoroidal space (SCS) or the supraciliary space of the eye of the subject in need thereof. The present disclosure further comprises facilitating and improving the aqueous outflows in the eye through the trabecular meshwork outflow pathway and/or uveoscleral outflow pathway and thereby decreasing the intraocular pressure.