公开(公告)号：US20150258120A1

公开(公告)日：2015-09-17

申请号：US14441151

申请日：2013-11-08

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke

IPC: A61K31/573 ,  A61K9/00 ,  A61M37/00 ,  A61K9/16

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract translation: 提供了用于将药物制剂靶向非手术施用于人受试者眼睛的脉络膜上空间（SCS）以治疗后眼部疾病或脉络膜性疾病的方法和装置。 在一个实施例中，该方法包括在插入部位将中空微针插入眼睛，并将药物制剂通过插入的微针并进入眼睛的脉络膜上空间，其中输注的药物制剂在远离插入物的脉管外空间内流动 输液过程中的位置。 在一个实施方案中，流体药物制剂包含药物纳米颗粒或微粒。

公开(公告)号：US20230157869A1

公开(公告)日：2023-05-25

申请号：US18156684

申请日：2023-01-19

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor ANDINO ,  Vladimir Zarnitsyn ,  Jesse Yoo ,  Christopher John Brooks ,  Trent John Kahute ,  Justin William Arsenault ,  David Jackson Trettin ,  Andrew Kent Bauer ,  Stephanie Elaine Lewis

IPC: A61F9/00 ,  A61M5/20 ,  A61M5/48 ,  A61J1/20 ,  A61M5/46 ,  A61M37/00 ,  A61M5/31 ,  A61M5/34 ,  A61M5/32

CPC classification number: A61F9/0017 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/482 ,  A61J1/2096 ,  A61J1/201 ,  A61J1/2055 ,  A61M5/46 ,  A61M37/0015 ,  A61M5/31 ,  A61M5/34 ,  A61M5/3293 ,  A61M5/344 ,  A61M5/346 ,  A61M5/347 ,  A61M5/348 ,  A61M5/349 ,  A61M2005/31508

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US10722396B2

公开(公告)日：2020-07-28

申请号：US16591067

申请日：2019-10-02

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Rafael Victor Andino ,  Vladimir Zarnitsyn ,  Jesse Yoo ,  Christopher John Brooks ,  Trent John Kahute ,  Justin William Arsenault ,  David Jackson Trettin ,  Andrew Kent Bauer ,  Stephanie Elaine Lewis

IPC: A61F9/00 ,  A61M5/20 ,  A61M5/48 ,  A61J1/20 ,  A61M5/46 ,  A61M37/00 ,  A61M5/31 ,  A61M5/34 ,  A61M5/32 ,  A61M5/315

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US10188550B2

公开(公告)日：2019-01-29

申请号：US14894161

申请日：2014-05-30

Applicant: Clearside Biomedical, Inc.

Inventor： Rafael Victor Andino ,  Samirkumar R. Patel ,  Vladimir Zarnitsyn ,  Christopher John Brooks

IPC: A61F9/00 ,  A61M5/19 ,  A61J1/20 ,  A61M5/315 ,  A61M5/28

Abstract: A cartridge, including a first member that defines an inner volume and a second member disposed therein, is disposed in a housing. A first reservoir is disposed in the inner volume in a position distal to the second member. The first member is partially disposed in a second reservoir, defined by the housing. The second member is configured to be moved from a first position, in which the first reservoir contains a drug and the second reservoir is fluidically isolated from the inner volume, toward a second position, in which the first reservoir and the second reservoir are in fluid communication with the inner volume, such that the second reservoir receives a volume of the drug from the first reservoir. The first member and the second member are collectively moved relative to the second reservoir to expel the volume of the drug from the second reservoir.

公开(公告)号：US09956114B2

公开(公告)日：2018-05-01

申请号：US15383582

申请日：2016-12-19

Applicant: Clearside Biomedical, Inc.

Inventor： Rafael Victor Andino ,  Christopher John Brooks ,  Vladimir Zarnitsyn ,  Harrison J. White

IPC: A61F9/00 ,  A61M5/32 ,  A61M37/00 ,  A61M5/46

CPC classification number: A61F9/0008 ,  A61M5/3286 ,  A61M5/329 ,  A61M5/3293 ,  A61M5/46 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2210/0612

Abstract: An apparatus includes a microneedle that defines a lumen therethrough. The microneedle has a proximal end portion a distal end portion and a hub portion between the proximal end portion and the distal end portion. The proximal end portion is configured to be coupled to a medicament container, such as, for example a syringe. The portion of the lumen within the proximal end portion has a first diameter. The distal end portion is configured to pierce a target tissue. The portion of the lumen within the distal end portion has a second diameter smaller than the first diameter. The hub portion includes a surface configured to contact the target tissue when the distal end portion is disposed with the target tissue.

公开(公告)号：US09937075B2

公开(公告)日：2018-04-10

申请号：US15714441

申请日：2017-09-25

Applicant: Clearside Biomedical, Inc.

Inventor： Rafael Victor Andino ,  Vladimir Zarnitsyn ,  Jesse Yoo ,  Christopher John Brooks ,  Trent John Kahute ,  Justin William Arsenault ,  David Jackson Trettin ,  Andrew Kent Bauer ,  Stephanie Elaine Lewis

IPC: A61M5/00 ,  A61F9/00 ,  A61J1/20 ,  A61M5/20 ,  A61M5/32 ,  A61M5/34 ,  A61M5/46 ,  A61M5/48 ,  A61M37/00

CPC classification number: A61F9/0017 ,  A61F2250/0007 ,  A61F2250/0069 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2096 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/31 ,  A61M5/3293 ,  A61M5/34 ,  A61M5/344 ,  A61M5/346 ,  A61M5/347 ,  A61M5/348 ,  A61M5/349 ,  A61M5/46 ,  A61M5/482 ,  A61M37/0015 ,  A61M2005/31508 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2210/0612

Abstract: An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

公开(公告)号：US20180092897A1

公开(公告)日：2018-04-05

申请号：US15830727

申请日：2017-12-04

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke

IPC: A61K31/4439 ,  C07K16/22 ,  A61K47/26 ,  A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61M37/00 ,  A61K47/38 ,  A61K47/12 ,  A61K45/06 ,  A61K31/573 ,  A61K39/00

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US09931330B2

公开(公告)日：2018-04-03

申请号：US15673073

申请日：2017-08-09

Applicant: CLEARSIDE BIOMEDICAL, INC.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke

IPC: A61K31/4439 ,  A61K47/26 ,  A61K45/06 ,  A61K9/00 ,  A61K47/38 ,  A61K9/16 ,  A61K31/573 ,  A61K47/12 ,  A61K9/10 ,  A61K39/00 ,  A61M37/00 ,  C07K16/22

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

公开(公告)号：US09636332B2

公开(公告)日：2017-05-02

申请号：US15001610

申请日：2016-01-20

Applicant: Clearside Biomedical, Inc.

Inventor： Vladimir Zarnitsyn ,  Samirkumar Patel ,  Daniel White ,  Glenn Noronha ,  Brian Burke

IPC: A61K31/4439 ,  A61K47/12 ,  A61K47/26 ,  A61K9/16 ,  A61K45/06 ,  A61K31/573 ,  A61K9/10 ,  A61K9/00 ,  A61K47/38 ,  A61K39/00 ,  A61M37/00 ,  C07K16/22

CPC classification number: A61K31/4439 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/16 ,  A61K31/573 ,  A61K45/06 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2300/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061 ,  C07K16/22

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.