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    HYBRID FIXED BED CELL CULTURE SUBSTRATE AND BIOREACTOR
    13.
    发明申请
    HYBRID FIXED BED CELL CULTURE SUBSTRATE AND BIOREACTOR 有权

    公开(公告)号：US20250027020A1

    公开(公告)日：2025-01-23

    申请号：US18714867

    申请日：2022-11-17

    Applicant: CORNING INCORPORATED

    Inventor： Yujian Sun ,  Yue Zhou

    IPC: C12M1/12 ,  C12M3/00

    Abstract: A cell culture matrix for culturing cells in a fixed bed reactor is provided. The cell culture matrix includes a plurality of substrate layers in a stacked arrangement, with each layer being a substrate material with an ordered and regular array of openings passing through the layer, where the openings are separated by the substrate material, which has a physical structure that is substantially regular and uniform and that is for growing cell thereon. The plurality of substrate layers includes a first substrate material and a second substrate material that is different from the first substrate material in at least one physical dimension. The first substrate material and the second substrate material make up separate layers of the plurality of substrate layers.

    POLYMER-ENCAPSULATED MAGNETIC NANOPARTICLES
    16.
    发明申请
    POLYMER-ENCAPSULATED MAGNETIC NANOPARTICLES 审中-公开

    公开(公告)号：US20190326039A1

    公开(公告)日：2019-10-24

    申请号：US16391866

    申请日：2019-04-23

    Applicant: Corning Incorporated

    Inventor： Ann MeeJin Ferrie ,  Yan Jin ,  Lingyan Wang ,  Yue Zhou

    IPC: H01F1/12 ,  H01F1/00 ,  C12N15/10

    Abstract: Magnetic particles have a particle size of 500 nm of less and include a core and a polymer coating that surrounds and encapsulates the core. The core includes a metal, metal alloy, or metal oxide of at least one metal such as B, Mg, Al, Mn, Co, Ni, Cu, Fe Sm, Ln, Yb, Dy, Gd or Er and Nb. The magnetic core is polycrystalline particles which are superspin glass magnetic materials having coercivity greater than zero and magnetic remenance greater than zero at room temperature. Magnetic moment of these superspin glass magnetic materials at low field show increasing with temperature over room temperature. An in situ hydrolysis/precipitation method from precursor metal salts is used to form the polymer-encapsulated magnetic particles.

    POLYMER-ENCAPSULATED MAGNETIC NANOPARTICLES
    19.
    发明申请
    POLYMER-ENCAPSULATED MAGNETIC NANOPARTICLES 审中-公开

    公开(公告)号：US20180151278A1

    公开(公告)日：2018-05-31

    申请号：US15520581

    申请日：2015-10-23

    Applicant: CORNING INCORPORATED

    Inventor： Ann MeeJin Ferrie ,  Yan Jin ,  Lingyan Wang ,  Yue Zhou

    IPC: H01F1/12 ,  H01F1/00 ,  C12N15/10 ,  H01F1/34 ,  H01F1/36 ,  H01F1/20

    CPC classification number: H01F1/12 ,  C12N15/1013 ,  H01F1/0054 ,  H01F1/20 ,  H01F1/344 ,  H01F1/36

    Abstract: Magnetic particles (100) have a particle size (134) of 500 nm or less and include a core (110) and a polymer coating (120) that surrounds and encapsulates the core (110). The core (110) includes a metal, metal alloy, or metal oxide of at least one metal such as B, Mg, Al, Mn, Co, Ni, Cu, Fe Sm, Yb, Dy, Gd or Er and Nb. The magnetic core (100) is a polycrystalline particle and is a superspin glass magnetic material, having a coercivity greater than zero and a magnetic remenance greater than zero at room temperature. Above room temperature and at low field, the magnetic moment of these superspin glass magnetic materials increases with temperature. An in situ hydrolysis/precipitation method from precursor metal salts is used to form the polymer-encapsulated magnetic particles (100).

    MAGNETIC MICROCARRIERS
    20.
    发明申请
    MAGNETIC MICROCARRIERS 审中-公开
    磁性微型机

    公开(公告)号：US20160145600A1

    公开(公告)日：2016-05-26

    申请号：US14950771

    申请日：2015-11-24

    Applicant: Corning Incorporated

    Inventor： Stephen Joseph Caracci ,  Ye Fang ,  Ann MeeJin Ferrie ,  Yan Jin ,  Lingyan Wang ,  Yue Zhou

    IPC: C12N13/00 ,  H01F1/147 ,  H01F1/20 ,  C12N5/00 ,  G01N1/40

    CPC classification number: C12N13/00 ,  C12N1/02 ,  H01F1/26 ,  H01F1/37

    Abstract: Magnetic microcarrier beads have a particle size of 1 to 1000 micrometers and include a composite core and a polymer coating that surrounds and encapsulates the core. The composite core includes magnetic particles embedded within an indigestible polymer matrix. The coating is a digestible or indigestible polymer that facilitates cell adhesion to the surface of the beads during cell culture. Magnetic force can be used to agitate the microcarrier beads during cell culture as well as to separate the beads from cultured cells or processed bio-media.

    Abstract translation: 磁性微载体珠具有1至1000微米的粒度，并且包括复合芯和围绕并封装芯的聚合物涂层。 复合芯包括嵌入在难消化的聚合物基质内的磁性颗粒。 该涂层是可消化或消化不良的聚合物，其在细胞培养期间促进细胞与珠表面的粘附。 可以使用磁力在细胞培养过程中搅动微载体珠，以及将珠与培养的细胞或加工的生物培养基分离。

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