公开(公告)号：US10035806B2

公开(公告)日：2018-07-31

申请号：US15286983

申请日：2016-10-06

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Melanie A. Yen ,  Harry B. Gray ,  Robert H. Grubbs ,  Joshua Palmer

IPC: C07D487/22 ,  A61K31/409 ,  C07F5/00

CPC classification number: C07D487/22 ,  C07F5/003

Abstract: The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein.

公开(公告)号：US09636428B2

公开(公告)日：2017-05-02

申请号：US14492324

申请日：2014-09-22

Applicant: California Institute of Technology ,  Children's Hospital Los Angeles

Inventor： Carl M. Blumenfeld ,  Karn Sorasaenee ,  Harry B. Gray ,  Robert H. Grubbs

IPC: A61B5/055 ,  A61K49/16 ,  A61K49/10 ,  A61K47/48 ,  A61K49/00

CPC classification number: A61K49/16 ,  A61K47/557 ,  A61K49/00 ,  A61K49/0052 ,  A61K49/0058

Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II:

公开(公告)号：US20150202331A1

公开(公告)日：2015-07-23

申请号：US14492324

申请日：2014-09-22

Applicant: California Institute of Technology ,  Children's Hospital Los Angeles

Inventor： Carl M. Blumenfeld ,  Karn Sorasaenee ,  Harry B. Gray ,  Robert H. Grubbs

IPC: A61K49/16 ,  A61K49/10 ,  A61K49/00

CPC classification number: A61K49/16 ,  A61K47/557 ,  A61K49/00 ,  A61K49/0052 ,  A61K49/0058

Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本公开涉及包括式I和II的金属氧化物的磺酸酯：

公开(公告)号：US20180254478A1

公开(公告)日：2018-09-06

申请号：US15903553

申请日：2018-02-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Simon C. Jones ,  Emmanuelle Despagnet-Ayoub ,  Brendon McNicholas ,  Harry B. Gray ,  Robert H. Grubbs

IPC: H01M4/36 ,  H01M8/18 ,  H01M8/0202 ,  C07F15/02 ,  C07F15/06 ,  C07F13/00 ,  C07F11/00

CPC classification number: H01M4/368 ,  C07F11/00 ,  C07F13/00 ,  C07F15/02 ,  C07F15/06 ,  H01M4/9008 ,  H01M8/0202 ,  H01M8/188 ,  H01M2300/0025 ,  Y02E60/528

Abstract: In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a Lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a Lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex. The one or more first ligands independently may comprise a Lewis basic functional group and each of said one or more second ligands independently may comprise a Lewis acidic functional group.

公开(公告)号：US20150328313A1

公开(公告)日：2015-11-19

申请号：US14650208

申请日：2013-12-18

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Robert H. Chow ,  Mark S. Humayun ,  Harry B. Gray ,  Robert H. Grubbs ,  Dennis Dougherty ,  Mark Thompson ,  Oliver Shafaat ,  Erin Lamb

IPC: A61K41/00 ,  C12N13/00

CPC classification number: A61K41/00 ,  A61B3/113 ,  A61K41/0023 ,  A61N5/062 ,  A61N2005/0648 ,  C12N13/00

Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

Abstract translation: 方法和组合物调节电可兴奋细胞的活性。 在暴露于光能下，增加或减少细胞的电活动的光伏化合物。 这些补充和/或替代视觉基于视觉系统的某些单元内的光能转换为电能。 用于规避视觉系统中一个或多个缺陷，损坏或病变细胞的“补丁”或桥梁。 另外，在几个实施例中，具有正常视力的受试者可以受益于本文公开的方法，组合物，系统和/或装置，因为可以提高正常视力。 曝光引起能量（例如，光能的接收，电能的转换和电能的传递）从光伏化合物到细胞，从而改变细胞的跨膜电位和/或开放一个或 更多的离子通道，从而调节电可激发细胞的活性。

公开(公告)号：US08968789B2

公开(公告)日：2015-03-03

申请号：US14178592

申请日：2014-02-12

Applicant: California Institute of Technology ,  Children's Hospital of Los Angeles

Inventor： Carl M. Blumenfeld ,  Harry B. Gray ,  Robert H. Grubbs ,  Karn Sorasaenee

IPC: A61K49/08 ,  C07D487/22 ,  C07F5/00 ,  C07F5/06 ,  A61K49/00

CPC classification number: C07F7/28 ,  A61K49/0021 ,  A61K49/0065 ,  A61K49/0067 ,  B01J2531/025 ,  C07D487/22 ,  C07F5/003 ,  C07F5/069

Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:

Abstract translation: 本发明涉及包括式I和II的金属氧化物的磺酸酯：