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公开(公告)号：US20200095206A1
公开(公告)日：2020-03-26
申请号：US16484045
申请日：2018-02-06
发明人： Sanford Markowitz , Yiyuan Yuan , Yongyou Zhang , Joseph Ready , Bin Hu
IPC分类号： C07D235/18 , C07D239/74 , C07D241/42 , C12N9/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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12.发明申请公开(公告)号：US20180125829A1
公开(公告)日：2018-05-10
申请号：US15799307
申请日：2017-10-31
发明人： Sanford Markowitz , Amar Desai , Joseph Ready
IPC分类号： A61K31/4365 , A61K31/495 , A61K38/19
摘要： A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
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公开(公告)号：US20240043440A1
公开(公告)日：2024-02-08
申请号：US18057589
申请日：2022-11-21
发明人： Sanford Markowitz , Monika Antczak , Joseph Ready , Yongyou Zhang
IPC分类号： C07D495/04 , C07D495/22
CPC分类号： C07D495/04 , C07D495/22
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20230192717A1
公开(公告)日：2023-06-22
申请号：US17926214
申请日：2021-05-19
申请人： RODEO THERAPEUTICS CORPORATION , Case Western Reserve University , Board of Regents of the University of Texas System
发明人： Stephen L Gwaltney , Joseph Ready , Monika Antczak , Sanford Markowitz , Amar Desai , Stanton Gerson
IPC分类号： C07D495/04 , A61K45/06 , C07D519/00
CPC分类号： C07D495/04 , A61K45/06 , C07D519/00
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US11426420B2
公开(公告)日：2022-08-30
申请号：US16603544
申请日：2018-04-09
发明人： Sanford Markowitz , Won Jin Ho , Yiyuan Yuan , Mukesh Jain , Mohamed Sabeh , Joseph Ready , Noelle Williams
IPC分类号： A61K31/704 , A61P9/00 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/7048 , C07K16/32
摘要： A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
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公开(公告)号：US09789116B2
公开(公告)日：2017-10-17
申请号：US15029943
申请日：2014-10-15
发明人： Sanford Markowitz , James K. V. Willson , Bruce Posner , Joseph Ready , Monika Antczak , Yongyou Zhang , Amar Desai , Stanton Gerson , William Greenlee
IPC分类号： A61K31/535 , A61K31/5377 , A61K31/4365 , A61K31/519 , A61K31/437 , A61K31/444 , A61K31/496
CPC分类号： A61K31/5377 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519 , C07D495/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20170173028A1
公开(公告)日：2017-06-22
申请号：US15029943
申请日：2014-10-15
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Monika Antczak , Youngyou Zhang , Amar Desai , Stanton Gerson , William Greenlee
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/437 , A61K31/444 , A61K31/4365 , A61K31/519
CPC分类号： A61K31/5377 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519 , C07D495/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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公开(公告)号：US20230165883A1
公开(公告)日：2023-06-01
申请号：US17893777
申请日：2022-08-23
发明人： Sanford Markowitz , Won Jin Ho , Yiyuan Yuan , Mukesh Jain , Mohamad Sabeh , Joseph Ready , Noelle Williams
IPC分类号： A61K31/704 , A61P9/00 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/7048 , C07K16/32
CPC分类号： A61K31/704 , A61P9/00 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/7048 , C07K16/32
摘要： A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
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公开(公告)号：US20230136730A1
公开(公告)日：2023-05-04
申请号：US17879379
申请日：2022-08-02
发明人： Sanford Markowitz , James K.V. Willson , Bruce Posner , Joseph Ready , Monika Antczak , Yongyou Zhang , Amar Desai , Stanton Gerson , William Greenlee , Sung Yeun Yang , KiBeom Bae
IPC分类号： A61K31/5377 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
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20.发明授权公开(公告)号：US09801863B2
公开(公告)日：2017-10-31
申请号：US15347587
申请日：2016-11-09
发明人： Sanford Markowitz , Amar Desai , Stanton Gerson , Joseph Ready
IPC分类号： A61K31/4365 , A61K38/19 , A61K31/495
CPC分类号： A61K31/4365 , A61K31/495 , A61K38/193
摘要： A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
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