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公开(公告)号：US08828912B2
公开(公告)日：2014-09-09
申请号：US13446291
申请日：2012-04-13
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00385 , B01J2219/00576 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725 , B01L3/502715 , B01L2200/026 , B01L2200/0684 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/087 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , C12Q1/68 , G01N1/34 , G01N33/54386
摘要： A microarray assembly for detection of a target molecule is disclosed. The microarray assemblies comprise an array chamber having a microarray located therein and features that facilitate liquid movement within the array chamber. Also disclosed are methods for making the microarray assembly using rollable films and methods for detecting microarray spots using an internal control fluorophore in the array spot.
摘要翻译： 公开了一种用于检测靶分子的微阵列组件。 微阵列组件包括具有位于其中的微阵列的阵列室，其特征在于使阵列室内的液体移动。 还公开了使用可卷曲膜制造微阵列组件的方法和使用阵列斑点中的内部控制荧光团检测微阵列斑点的方法。
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公开(公告)号：US08680026B2
公开(公告)日：2014-03-25
申请号：US12840826
申请日：2010-07-21
IPC分类号： C40B60/12
CPC分类号： B01J19/0046 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725 , B01L3/502723 , B01L3/50273 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/165 , B01L2400/0406 , B01L2400/0688
摘要： A microarray system is disclosed. The microarray system includes a microarray formed on a planar substrate and an incubation chamber formed around the microarray. The incubation chamber has a plurality of interior surfaces including a bottom surface on which the microarray is formed and a top surface that faces the bottom surface and is generally parallel to the bottom surface. At least one of a plurality of interior surfaces is a hydrophilic surface.
摘要翻译： 公开了一种微阵列系统。 微阵列系统包括形成在平面基底上的微阵列和形成在微阵列周围的孵育室。 孵育室具有多个内表面，其包括形成微阵列的底表面和面向底表面并且大致平行于底表面的顶表面。 多个内表面中的至少一个是亲水表面。
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公开(公告)号：US08680025B2
公开(公告)日：2014-03-25
申请号：US12149865
申请日：2008-05-09
IPC分类号： C40B60/12
CPC分类号： B01J19/0046 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725
摘要： A microarray system is disclosed. The microarray system includes a microarray formed on a planar substrate and an incubation chamber formed around the microarray. The incubation chamber has a plurality of interior surfaces including a bottom surface on which the microarray is formed and a top surface that faces the bottom surface and is generally parallel to the bottom surface. At least one of a plurality of interior surfaces is a hydrophilic surface.
摘要翻译： 公开了一种微阵列系统。 微阵列系统包括形成在平面基底上的微阵列和形成在微阵列周围的孵育室。 孵育室具有多个内表面，其包括形成微阵列的底表面和面向底表面并且大致平行于底表面的顶表面。 多个内表面中的至少一个是亲水表面。
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公开(公告)号：US20120283423A1
公开(公告)日：2012-11-08
申请号：US13541353
申请日：2012-07-03
CPC分类号： G01N1/405 , B01D39/201 , B01L3/0275 , B01L3/502753 , B01L2200/0631 , B01L2300/0681 , C12N15/1017
摘要： Methods and devices for isolating nucleic acids from a mixture containing such nucleic acids and extraneous matter are provided. In one embodiment, the method of the invention comprises passing the mixture through a glass frit under conditions effective to separate the nucleic acids from the extraneous matter. In a more specific embodiment, the glass frit is a sintered glass frit.
摘要翻译： 提供了从含有这种核酸和外来物质的混合物中分离核酸的方法和装置。 在一个实施方案中，本发明的方法包括在有效将核酸与外来物质分离的条件下使混合物通过玻璃料。 在更具体的实施方案中，玻璃料是烧结玻璃料。
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公开(公告)号：US20110071055A1
公开(公告)日：2011-03-24
申请号：US12886201
申请日：2010-09-20
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L2200/026 , B01L2200/10 , B01L2300/0681 , G01N1/34
摘要： An integrated cartridge for sample processing and analysis is disclosed. The integrated cartridge contains a sample preparation chamber having a sample inlet and a sample outlet, and a sample purification chamber adapted to receive a replaceable sample purification unit containing a housing and an extraction filter inside the housing. The extraction filter specifically binds to a molecule of interest. The sample purification chamber has a sample inlet that is in fluid communication with the sample outlet of the sample preparation chamber. Also disclosed is a microarray-based sample analysis (MBSA) system.
摘要翻译： 公开了用于样品处理和分析的集成盒。 集成盒包含具有样品入口和样品出口的样品制备室，以及样品净化室，其适于在壳体内容纳容纳壳体和提取过滤器的可更换样品净化单元。 提取过滤器与感兴趣的分子特异性结合。 样品净化室具有与样品制备室的样品出口流体连通的样品入口。 还公开了基于微阵列的样品分析（MBSA）系统。
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公开(公告)号：US08623789B2
公开(公告)日：2014-01-07
申请号：US12886201
申请日：2010-09-20
IPC分类号： G01N33/00
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L2200/026 , B01L2200/10 , B01L2300/0681 , G01N1/34
摘要： An integrated cartridge for sample processing and analysis is disclosed. The integrated cartridge contains a sample preparation chamber having a sample inlet and a sample outlet, and a sample purification chamber adapted to receive a replaceable sample purification unit containing a housing and an extraction filter inside the housing. The extraction filter specifically binds to a molecule of interest. The sample purification chamber has a sample inlet that is in fluid communication with the sample outlet of the sample preparation chamber. Also disclosed is a microarray-based sample analysis (MBSA) system.
摘要翻译： 公开了用于样品处理和分析的集成盒。 集成盒包含具有样品入口和样品出口的样品制备室，以及样品净化室，其适于在壳体内容纳容纳壳体和提取过滤器的可更换样品净化单元。 提取过滤器与感兴趣的分子特异性结合。 样品净化室具有与样品制备室的样品出口流体连通的样品入口。 还公开了基于微阵列的样品分析（MBSA）系统。
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公开(公告)号：US08603783B2
公开(公告)日：2013-12-10
申请号：US13564523
申请日：2012-08-01
申请人： Phillip Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
发明人： Phillip Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
IPC分类号： C12P19/34
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
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公开(公告)号：US20110207632A1
公开(公告)日：2011-08-25
申请号：US13098195
申请日：2011-04-29
申请人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
发明人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
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公开(公告)号：US07955841B2
公开(公告)日：2011-06-07
申请号：US12232669
申请日：2008-09-22
申请人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
发明人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
IPC分类号： C12M1/38
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
摘要翻译： 公开了一种用于控制反应室中的温度的装置。 该装置包括：囊组件，其包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体; 以及设置在所述壳体内的第一温度控制气囊，所述第一温度控制气囊构造成接收温度控制流体并且包括柔性的导热表面，所述表面与所述壳体的外表面的至少一部分接触 反应室接收温度控制液后。 还公开了膀胱热循环仪，温度控制气囊组件和在反应室中产生热循环的方法。
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公开(公告)号：US20090087903A1
公开(公告)日：2009-04-02
申请号：US12232669
申请日：2008-09-22
申请人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
发明人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
IPC分类号： C12M1/00
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
摘要翻译： 公开了一种用于控制反应室中的温度的装置。 该装置包括：囊组件，其包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体; 以及设置在所述壳体内的第一温度控制气囊，所述第一温度控制气囊构造成接收温度控制流体并且包括柔性的导热表面，所述表面与所述壳体的外表面的至少一部分接触 反应室接收温度控制液后。 还公开了膀胱热循环仪，温度控制气囊组件和在反应室中产生热循环的方法。
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