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公开(公告)号：US09074245B2
公开(公告)日：2015-07-07
申请号：US13542111
申请日：2012-07-05
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L2200/026 , B01L2200/10 , B01L2300/0681 , G01N1/34
摘要： A microarray-based sample analysis (MBSA) system includes a cartridge holder adapted to receive a replaceable cartridge that is configured to receive a detachable, replaceable sample analysis unit containing one or more reaction chambers for sample analysis; a fluid control subsystem that controls fluid flow; and an optical subsystem configured to capture an image of the microarray.
摘要翻译： 基于微阵列的样本分析（MBSA）系统包括适于接收替换的盒的盒保持器，其被配置为接收包含用于样本分析的一个或多个反应室的可拆卸的可更换样品分析单元; 控制流体流动的流体控制子系统; 以及被配置为捕获微阵列的图像的光学子系统。
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公开(公告)号：US20090111193A1
公开(公告)日：2009-04-30
申请号：US12213942
申请日：2008-06-26
CPC分类号： G01N1/34 , B01L3/5025 , B01L2200/0631 , B01L2300/0681 , B01L2300/0832 , G01N1/405 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： A sample preparation device is disclosed. The sample preparation device includes a housing defining a passage way between a first opening and a second opening; and a sample filter occupying a section of said passage way. The sample filter contains a monolith adsorbent that specifically binds to nucleic acids. Also disclosed are sample filters containing glass frit is coated with an capture agent that binds specifically to an analyte of interest, sample filters containing a hydrophilic matrix with impregnated chemicals that lyses cell membranes, a cartridge base and an integrated sample preparation cartridge.
摘要翻译： 公开了一种样品制备装置。 样品制备装置包括限定第一开口和第二开口之间的通道的壳体; 以及占据所述通道的一部分的样品过滤器。 样品过滤器包含与核酸特异性结合的整料吸附剂。 还公开了包含玻璃料的样品过滤器，其涂覆有特异性结合目的分析物的捕获剂，包含亲水基质的样品过滤器，其中浸渍的化学物质裂解细胞膜，滤筒基底和集成样品制备盒。
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公开(公告)号：US08759085B2
公开(公告)日：2014-06-24
申请号：US13098195
申请日：2011-04-29
申请人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
发明人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
摘要翻译： 公开了一种用于控制反应室中的温度的装置。 该装置包括：囊组件，其包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体; 以及设置在所述壳体内的第一温度控制气囊，所述第一温度控制气囊构造成接收温度控制流体并且包括柔性的导热表面，所述表面与所述壳体的外表面的至少一部分接触 反应室接收温度控制液后。 还公开了膀胱热循环仪，温度控制气囊组件和在反应室中产生热循环的方法。
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公开(公告)号：US08334117B2
公开(公告)日：2012-12-18
申请号：US13098299
申请日：2011-04-29
申请人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
发明人： Phil Belgrader , Christopher G. Cooney , Robert Doebler , Anna Hickerson , Bruce Irvine , Ali Nadim , James Sterling , Reza Miraghaie
IPC分类号： C12P19/34
CPC分类号： B01L7/52 , B01J2219/00495 , B01J2219/00531 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , B01L7/525 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2300/1805 , B01L2300/185 , C12M23/48 , C12M41/40 , C12P19/34 , G05D23/185
摘要： A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.
摘要翻译： 公开了一种用于控制反应室中的温度的装置。 该装置包括：囊组件，其包括尺寸适于容纳设置在壳体的内部容积内的反应室的壳体; 以及设置在所述壳体内的第一温度控制气囊，所述第一温度控制气囊构造成接收温度控制流体并且包括柔性的导热表面，所述表面与所述壳体的外表面的至少一部分接触 反应室接收温度控制液后。 还公开了膀胱热循环仪，温度控制气囊组件和在反应室中产生热循环的方法。
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公开(公告)号：US20120071355A9
公开(公告)日：2012-03-22
申请号：US12149865
申请日：2008-05-09
CPC分类号： B01J19/0046 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725
摘要： A microarray system is disclosed. The microarray system includes a microarray formed on a planar substrate and an incubation chamber formed around the microarray. The incubation chamber has a plurality of interior surfaces including a bottom surface on which the microarray is formed and a top surface that faces the bottom surface and is generally parallel to the bottom surface. At least one of a plurality of interior surfaces is a hydrophilic surface.
摘要翻译： 公开了一种微阵列系统。 微阵列系统包括形成在平面基底上的微阵列和形成在微阵列周围的孵育室。 孵育室具有多个内表面，其包括形成微阵列的底表面和面向底表面并且大致平行于底表面的顶表面。 多个内表面中的至少一个是亲水表面。
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公开(公告)号：US10300482B2
公开(公告)日：2019-05-28
申请号：US13314734
申请日：2011-12-08
申请人： Christopher G. Cooney , Phillip Belgrader , Arial Bueno , Steve Garber , Nitu Harshendu Thakore , Peter Qiang Qu
发明人： Christopher G. Cooney , Phillip Belgrader , Arial Bueno , Steve Garber , Nitu Harshendu Thakore , Peter Qiang Qu
摘要： An integrated sample analysis system is disclosed. The sample analysis system contains (1) a sample preparation/analysis module having sample purification device comprising a monolith that binds specifically to nucleic acids and a sample analysis device comprising a microarray enclosed in a reaction chamber having a hydrophilic interior surface; (2) a temperature control module comprising a thermocycler having a thermally conductive temperature-control bladder; and (3) an imaging device capable of capturing an image of the microarray in the reaction chamber.
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公开(公告)号：US20130079253A1
公开(公告)日：2013-03-28
申请号：US13542111
申请日：2012-07-05
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01L3/502715 , B01L2200/026 , B01L2200/10 , B01L2300/0681 , G01N1/34
摘要： A microarray-based sample analysis (MBSA) system includes a cartridge holder adapted to receive a replaceable cartridge that is configured to receive a detachable, replaceable sample analysis unit containing one or more reaction chambers for sample analysis; a fluid control subsystem that controls fluid flow; and an optical subsystem configured to capture an image of the microarray.
摘要翻译： 基于微阵列的样本分析（MBSA）系统包括适于接收替换的盒的盒保持器，其被配置为接收包含用于样本分析的一个或多个反应室的可拆卸的可更换样品分析单元; 控制流体流动的流体控制子系统; 以及被配置为捕获微阵列的图像的光学子系统。
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公开(公告)号：US20100284859A1
公开(公告)日：2010-11-11
申请号：US12840826
申请日：2010-07-21
IPC分类号： G01N33/00
CPC分类号： B01J19/0046 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725 , B01L3/502723 , B01L3/50273 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/165 , B01L2400/0406 , B01L2400/0688
摘要： A microarray system is disclosed. The microarray system includes a microarray formed on a planar substrate and an incubation chamber formed around the microarray. The incubation chamber has a plurality of interior surfaces including a bottom surface on which the microarray is formed and a top surface that faces the bottom surface and is generally parallel to the bottom surface. At least one of a plurality of interior surfaces is a hydrophilic surface.
摘要翻译： 公开了一种微阵列系统。 微阵列系统包括形成在平面基底上的微阵列和形成在微阵列周围的孵育室。 孵育室具有多个内表面，其包括形成微阵列的底表面和面向底表面并且大致平行于底表面的顶表面。 多个内表面中的至少一个是亲水表面。
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公开(公告)号：US20090280997A1
公开(公告)日：2009-11-12
申请号：US12149865
申请日：2008-05-09
CPC分类号： B01J19/0046 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00722 , B01J2219/00725
摘要： This invention embodies a method that can be used to increase the porosity of the gel substrate during the fabrication of microchips. This increase in gel porosity will allow larger molecules such as non-fragmented RNAs and DNA fragments greater then 100 base pairs in length, and proteins to be immobilized and introduced within the gel microchips.
摘要翻译： 本发明体现了一种可用于在制造微芯片期间增加凝胶基质的孔隙率的方法。 凝胶孔隙度的这种增加将允许更大的分子例如非片段RNA和DNA片段长度大于100个碱基对，并且蛋白质被固定并引入凝胶微芯片内。
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公开(公告)号：US20080124716A1
公开(公告)日：2008-05-29
申请号：US11605353
申请日：2006-11-29
CPC分类号： C12Q1/6813
摘要： Rapid detection of biomolecules in samples involving biochemical amplification of the target biomolecule is achieved by collecting or separating aliquots of the amplification reaction mixture prior to completion of amplification and assaying these samples as they are collected.
摘要翻译： 通过在扩增反应混合物的等分试样收集或分离之前，通过收集或分离这些样品进行分析，可以快速检测涉及靶生物分子生物化学扩增的样品中的生物分子。
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