SENSOR CARTRIDGE
    12.
    发明申请
    SENSOR CARTRIDGE 审中-公开
    传感器盒

    公开(公告)号:US20100289483A1

    公开(公告)日:2010-11-18

    申请号:US12669218

    申请日:2008-07-16

    IPC分类号: G01N27/74

    CPC分类号: G01R33/1269

    摘要: The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).

    摘要翻译: 本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒(10)。 传感器盒(10)包括反应室(1)和至少彼此不同的第一和第二区域(2,3)。 第一区域(2)包括用第一类型的探针标记的磁性或可磁化物体(4a),用于特异性地结合第一类型的靶部分,并且第二区域(3)包括用第二类型标记的磁性或可磁化物体(4b) 的用于特异性结合第二类型的靶部分的探针,第一和第二区域(2,3)中的磁性或可磁化物体(4a,4b)可由样品流体直接接触。 本发明还提供了用于制造这种传感器装置(10)的方法以及使用这种传感器盒(10)确定样品流体中至少两种不同靶部分的存在和/或量的方法。

    CONTROLLABLE MAGNETIC SYSTEM FOR BIOSENSORS
    13.
    发明申请
    CONTROLLABLE MAGNETIC SYSTEM FOR BIOSENSORS 审中-公开
    生物传感器的可控磁系统

    公开(公告)号:US20090209042A1

    公开(公告)日:2009-08-20

    申请号:US12299788

    申请日:2007-05-08

    IPC分类号: G01N27/00

    CPC分类号: G01N33/54333 G01N27/745

    摘要: The invention relates to a magnetic system for biosensors and in particular to a magnetic system which can switch between attraction force and repulsion force near the sensor surface with more easy but also more effective means. This is realised with at least one coil (2) and at least two ferromagnetic cores (3) which are arranged in a concentric multilayered package, and a sensor or a sensor surface exposed to or covered with the biomaterial, which is arranged near to the magnetic system.

    摘要翻译: 本发明涉及一种用于生物传感器的磁性系统,特别涉及一种能够以更容易但更有效的方式在传感器表面附近的吸引力和排斥力之间切换的磁性系统。 这是通过布置在同心多层封装中的至少一个线圈(2)和至少两个铁磁芯(3)实现的,以及暴露于或覆盖生物材料的传感器或传感器表面,其布置在 磁系统。

    Data-Dependent Noise Predictor in Data-Aided Timing Recovery
    14.
    发明申请
    Data-Dependent Noise Predictor in Data-Aided Timing Recovery 审中-公开
    数据辅助定时恢复中的数据依赖噪声预测器

    公开(公告)号:US20080219392A1

    公开(公告)日:2008-09-11

    申请号:US11995013

    申请日:2006-07-06

    IPC分类号: H04L7/00 H04L25/00

    摘要: A communication system includes a communication channel (110) for time-synchronous transfer of data symbols a1, . . . , aN to a receiver (130). A sampling unit (132) is used for time-sequential sampling the channel under control of a sampling clock signal that is synchronous with transmittal of the data symbols. Each sample includes a representation of a data symbol and noise. A data-aided timing error detector (133) receives a representation of the samples. The detector includes a data-dependent noise predictor (310) for generating a predicted noise sequence ñ1, . . . , ñN where each predicted noise value nk for the k-th sample of the sequence depends on a cluster of a plurality of sampled data symbols and a noise whitening unit (320) for whitening of noise in the sample sequence by removing the predicted noise value ñk. The detector is arranged to provide a signal for correcting the sampling clock signal in dependence on the whitened sample sequence.

    摘要翻译: 一种通信系统包括用于数据符号a 1的时间同步传送的通信信道(110)。 。 。 ,向接收机(130)发送一个“N”。 采样单元(132)用于在与数据符号的发送同步的采样时钟信号的控制下对信道进行时间序列采样。 每个样本包括数据符号和噪声的表示。 数据辅助定时误差检测器(133)接收样本的表示。 检测器包括用于产生预测噪声序列的数据相关噪声预测器(310)。 。 。 ,其中序列的第k个样本的每个预测噪声值n k k取决于多个采样数据符号的簇和噪声白化单元( 320),用于通过去除预测的噪声值ñN k来采样序列中的噪声增白。 检测器被布置成根据白化样本序列提供用于校正采样时钟信号的信号。

    Accurate Magnetic Biosensor
    15.
    发明申请
    Accurate Magnetic Biosensor 审中-公开
    精确的磁性生物传感器

    公开(公告)号:US20080206104A1

    公开(公告)日:2008-08-28

    申请号:US11917211

    申请日:2006-06-12

    IPC分类号: B01J19/00 G01R33/09

    摘要: The invention provides a method, a device and a system for determining the concentration of at least one sort of targets in a fluid containing at least one sort of polarizable of polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable to specifically attach to at least one sort of biological entities linked to the magnetic labels, the sensing device further comprising at least one magnetic sensor element, the sensing device further comprising distinction means for time-resolved distinguishing between magnetic labels specifically attached to the binding sites versus labels non-specifically attached. The method and device according to the present invention may be applied to biomolecular diagnostics.

    摘要翻译: 本发明提供了一种用于确定在流体中含有至少一种可极化的极化磁性标签的流体中的至少一种靶的浓度的方法,装置和系统,所述感测表面包括至少一种结合 所述感测装置还包括至少一个磁性传感器元件,所述感测装置还包括用于时间分辨的区分装置,所述区别装置用于特别附着于所述磁性标签的磁性标签 结合位点与非特异性连接的标记。 根据本发明的方法和装置可以应用于生物分子诊断。

    Spherical Aberration Detector
    17.
    发明申请
    Spherical Aberration Detector 审中-公开
    球面异常检测器

    公开(公告)号:US20080192600A1

    公开(公告)日:2008-08-14

    申请号:US11915633

    申请日:2006-05-22

    IPC分类号: G11B5/58

    摘要: An optical scanning device (1) for scanning at least one information layer (2) of at least one optical record carrier (3). The device includes a radiation source (7) for providing at least a first radiation beam (4) comprising a first wavelength, an objective lens system (8) for converging the first radiation beam on a respective information layer (2), an information detector (23) for detecting at least a portion of the first radiation beam (22) reflected from the respective information layer, for determining information on said layer, and a spherical aberration detection system. The spherical aberration detection system includes an aberration detector (24) for detecting at least a portion of the reflected first radiation beam for determining spherical aberration of the first radiation beam, and a diffractive element (26) for diffracting at least a portion of the reflected first radiation beam towards the aberration detector (24), and for transmitting at least a portion of the reflected first radiation beam towards the information detector (23). In a first mode of operation the grating is arranged to introduce a phase change to an incident portion of a radiation beam for transmitting that portion towards the information detector (23). In a second mode of operation the grating is arranged to introduce a phase change to an incident portion of the reflected first radiation beam for diffracting that portion towards the aberration detector (24).

    摘要翻译: 一种用于扫描至少一个光学记录载体(3)的至少一个信息层(2)的光学扫描装置(1)。 该装置包括用于提供至少包括第一波长的第一辐射束(4)的辐射源(7),用于将第一辐射束会聚在相应的信息层(2)上的物镜系统(8),信息检测器 (23),用于检测从各个信息层反射的第一辐射束(22)的至少一部分,用于确定关于所述层的信息,以及球面像差检测系统。 球面像差检测系统包括:像差检测器(24),用于检测用于确定第一辐射束的球面像差的反射的第一辐射束的至少一部分;以及衍射元件(26),用于衍射至少部分反射 朝向像差检测器(24)的第一辐射束,并且用于将反射的第一辐射束的至少一部分传送到信息检测器(23)。 在第一操作模式中,光栅布置成将相位变化引入辐射束的入射部分,以将该部分传送到信息检测器(23)。 在第二操作模式中,光栅布置成将相变引入到反射的第一辐射束的入射部分,以将该部分衍射到像差检测器(24)。

    Method for detecting redispersion of beads
    18.
    发明授权
    Method for detecting redispersion of beads 有权
    检测珠子再分散的方法

    公开(公告)号:US08339608B2

    公开(公告)日:2012-12-25

    申请号:US12740148

    申请日:2008-10-30

    IPC分类号: G01N21/55

    摘要: A method of detecting redispersion of particles into a solution using for example FTIR. The method including providing a sensor surface with dry particles; illuminating the sensor surface with light along a first optical path and detecting the light reflected by the sensor surface; providing a liquid to a volume in contact with the sensor surface; and detecting the reflected light while the dry particles redisperse into the liquid. The angle between the first optical path and the sensor surface fulfils the condition of total internal reflection. Further, an FTIR cartridge may be provided for use in said method. The cartridge including a sensor surface accessible for FTIR detection including at least one binding area wherein label particles are situated.

    摘要翻译: 使用例如FTIR检测颗粒再次分散到溶液中的方法。 该方法包括向传感器表面提供干燥颗粒; 用沿着第一光路的光照射传感器表面并检测由传感器表面反射的光; 向与传感器表面接触的体积提供液体; 并且当干燥颗粒再分散到液体中时检测反射光。 第一光路和传感器表面之间的角度满足全内反射的条件。 此外,可以提供用于所述方法的FTIR盒。 该盒包括可用于FTIR检测的传感器表面,包括标签颗粒所在的至少一个结合区域。

    FLUID PROVIDING APPARATUS
    20.
    发明申请
    FLUID PROVIDING APPARATUS 有权
    流体提供装置

    公开(公告)号:US20110093213A1

    公开(公告)日:2011-04-21

    申请号:US13000031

    申请日:2009-06-22

    IPC分类号: G06F19/00 G01N21/59 G01N21/55

    摘要: The invention relates to a fluid providing apparatus (5; 34) for providing a fluid to an analyzing apparatus (17; 33) for analyzing the fluid and to the analyzing apparatus (17; 33). The fluid providing apparatus (34) comprises a casing (35), which has an introduction opening (7), through which a fluid transferring element (1) is introducible into the casing (35) for transferring the fluid to the fluid providing apparatus (34). The casing (35) comprises further a fluid releasing section (8) for releasing the fluid from the fluid transferring element (1) and a fluid transferring element detection section (36) for detecting whether the fluid transferring element (1) is introduced into the casing (35) by interacting with a fluid transferring element detection unit of the analyzing apparatus (17; 33).

    摘要翻译: 本发明涉及一种用于向用于分析流体和分析装置(17; 33)的分析装置(17; 33)提供流体的流体提供装置(5; 34)。 流体提供装置(34)包括具有引入开口(7)的壳体(35),流体转移元件(1)可以通过该导入开口引入到壳体(35)中,用于将流体传送到流体提供装置 34)。 壳体(35)还包括用于从流体传送元件(1)释放流体的流体释放部分(8)和用于检测流体传递元件(1)是否被引入到流体传输元件 壳体(35)通过与分析装置(17; 33)的流体转移元件检测单元相互作用。