公开(公告)号：US11913868B2

公开(公告)日：2024-02-27

申请号：US17302651

申请日：2021-05-10

Applicant: CYTEK BIOSCIENCES, INC.

Inventor： Ming Yan ,  Yung-Chieh Hsieh ,  David Vrane ,  Eric Chase

IPC: G01N15/00 ,  G01J3/00 ,  G01J1/08 ,  G01N21/47 ,  G01N15/14 ,  G01J3/02 ,  G01J3/36 ,  G01N15/10 ,  G01J3/12

CPC classification number: G01N15/1436 ,  G01J1/08 ,  G01J3/021 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/36 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/47 ,  G01J2003/1213 ,  G01N2015/1006 ,  G01N2015/145

Abstract: In one embodiment, a flow cytometer is disclosed having a compact light detection module. The compact light detection module includes an image array with a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side. Each of the plurality of filters reflects light to one of the plurality of micro-mirrors and passes light of a differing wavelength range and each of the plurality of micro-mirrors reflects light to one of the plurality of filters, such that incident light into the image array zigzags back and forth between consecutive filters of the plurality of filters and consecutive micro-mirrors of the plurality of micro-mirrors. A radius of curvature of each of the plurality of micro-mirrors images the fiber aperture onto the odd filters and collimates the light beam on the even filters.

公开(公告)号：US11169076B2

公开(公告)日：2021-11-09

申请号：US15659610

申请日：2017-07-25

Applicant: CYTEK BIOSCIENCES, INC.

Inventor： Ming Yan ,  Yung-Chieh Hsieh ,  David Vrane ,  Eric Chase

IPC: G01N15/00 ,  G01N21/00 ,  G01J3/00 ,  G01N15/14 ,  G01J1/08 ,  G01J3/02 ,  G01J3/36 ,  G01N21/47 ,  G01J3/12 ,  G01N15/10

Abstract: In one embodiment, a flow cytometer is disclosed having a compact light detection module. The compact light detection module includes an image array with a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side. Each of the plurality of filters reflects light to one of the plurality of micro-mirrors and passes light of a differing wavelength range and each of the plurality of micro-mirrors reflects light to one of the plurality of filters, such that incident light into the image array zigzags back and forth between consecutive filters of the plurality of filters and consecutive micro-mirrors of the plurality of micro-mirrors. A radius of curvature of each of the plurality of micro-mirrors images the fiber aperture onto the odd filters and collimates the light beam on the even filters.

公开(公告)号：US20180299367A1

公开(公告)日：2018-10-18

申请号：US15942430

申请日：2018-03-30

Applicant: CYTEK BIOSCIENCES, INC.

Inventor： Ming Yan ,  Yung-Chieh Hsieh ,  David Vrane ,  Eric Chase ,  Wenbin Jiang

IPC: G01N15/14 ,  G01N21/53 ,  G01N21/64 ,  G01J3/44 ,  G01J3/14 ,  G01J3/18

Abstract: A system, an apparatus, and a method are provided for a modular flow cytometer with a compact size. In one embodiment, the modular flow cytometry system includes the following: a laser system for emitting laser beams; a flow cell assembly positioned to receive the laser beams at an interrogation region of a fluidics stream where fluoresced cells scatter the laser beams into fluorescent light; a fiber assembly positioned to collect the fluorescent light; and a compact light detection module including a first image array having a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side.

公开(公告)号：US20170307505A1

公开(公告)日：2017-10-26

申请号：US15498397

申请日：2017-04-26

Applicant: CYTEK BIOSCIENCES, INC.

Inventor： David Vrane ,  Ming Yan ,  Eric Chase ,  Wenbin Jiang

IPC: G01N15/14 ,  G01N21/64 ,  G01N15/00 ,  G01N15/10

Abstract: A system, an apparatus, and a method are provided for a modular flow cytometer with a compact size. In one embodiment, the modular flow cytometry system includes the following: a laser system for emitting laser beams; a flow cell assembly positioned to receive the laser beams at an interrogation region of a fluidics stream where fluoresced cells scatter the laser beams into fluorescent light; a fiber assembly positioned to collect the fluorescent light; and a grating system including a dispersive element and a receiver assembly, wherein the dispersive element is positioned to receive the fluorescent light from the fiber assembly and to direct spectrally dispersed light toward the receiver assembly.

公开(公告)号：US20170307503A1

公开(公告)日：2017-10-26

申请号：US15494260

申请日：2017-04-21

Applicant: CYTEK BIOSCIENCES, INC.

Inventor： Ming Yan ,  Eric Chase ,  Yung-Chieh Hsieh

IPC: G01N15/14 ,  G02B1/08 ,  G02B27/28 ,  G02B5/30 ,  G01N15/00

Abstract: A system, method, and apparatus are provided for cytometry with dual laser beams. In one example, the method includes directing an incident light beam from a source to enter an optical waveplate; polarizing the incident light beam into a polarized light beam in response to the incident light beam entering through the optical waveplate; directing the polarized light beam to enter a birefringent crystal; separating the polarized light beam into an ordinary light beam and an extraordinary light beam in response to the polarized light beam entering the birefringent crystal; directing the ordinary light beam and the extraordinary light beam to enter a lens; focusing the ordinary light beam and the extraordinary light beam into dual light beams separated by a beam displacement; and coupling the dual light beams to form a sample region having substantially uniform light intensity to analyze moving particles in the particle analyzer.