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公开(公告)号:US11961295B2
公开(公告)日:2024-04-16
申请号:US17822068
申请日:2022-08-24
Applicant: Cytiva Sweden AB
Inventor: Petra Bangtsson , Johan Arthursson , Key Hyckenberg , Lotta Hedkvist
CPC classification number: G06V20/20 , G06T7/001 , G06T11/00 , G06T2207/30164
Abstract: A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.
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公开(公告)号:US20230046191A1
公开(公告)日:2023-02-16
申请号:US17822068
申请日:2022-08-24
Applicant: Cytiva Sweden AB
Inventor: Petra Bangtsson , Johan Arthursson , Key Hyckenberg , Lotta Hedkvist
Abstract: A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.
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公开(公告)号:US20210269888A1
公开(公告)日:2021-09-02
申请号:US17253067
申请日:2019-07-01
Applicant: Cytiva Sweden AB
Inventor: Key Hyckenberg , Helena Skoglar , Gunnar Malmquist , Mikael Carlsten , Roger Lundqvist , Dan Andersson , Linda Mathiasson , Lars Mattsson , Sara Sendabo , Mikael Berg
Abstract: The present invention relates to a method for optimizing a bioprocess purification system comprising a bioreactor configured to provide a harvest comprising a target composition, and a purification process arranged downstream the bioreactor and being configured for purification of the harvest to produce a target product having a desired characteristics. The method comprising: a) detecting (32) at least one quality attribute indicative of characteristics of the target product in a downstream process, b) identifying (33) correlations between the at least one quality attribute measured in the downstream process and parameters to control a cell culture process in the bioreactor, and c) controlling (34) the cell culture process to meet the desired characteristics based on the identified correlations, whereby the target characteristics is within a pre-determined range.
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公开(公告)号:US20240096096A1
公开(公告)日:2024-03-21
申请号:US18525144
申请日:2023-11-30
Applicant: Cytiva Sweden AB
Inventor: Petra Bangtsson , Johan Arthursson , Key Hyckenberg , Lotta Hedkvist
CPC classification number: G06V20/20 , G06T7/001 , G06T11/00 , G06T2207/30164
Abstract: A method of automated configuration in a bioprocess system and to verify a process defined by a flow path representation. The method comprises the steps of: capturing one image of the bioprocess system comprising tubing for the fluid communication between units of the bioprocess system; analyzing the captured image to identify the tubing connecting units of the bioprocess system; producing a processed representation from the captured image wherein at least a part of the tubing is identified; and comparing the processed representation with the flow path representation to verify their functional concordance.
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15.
公开(公告)号:US20230028051A1
公开(公告)日:2023-01-26
申请号:US17938618
申请日:2022-10-06
Applicant: Cytiva Sweden AB
Inventor: Jens Widehammar , Key Hyckenberg , Orjan Grelsson , Lars Mattsson , Kjell Karlsson
IPC: G01N30/86
Abstract: The present invention relates to a liquid chromatography system configured to operate with at least one column and configured for purification of a sample comprising a target product using a predefined process. The liquid chromatography system comprises a controller configured to: control the operation of the chromatography system to run the predefined process; retrieve column data accessible from a data storage, the column data being specific to each column; and adapt at least one process parameter of the predefined process for each column based on column data. Whereby the predefined process is adapted to each column to obtain the target product and maintain the performance of the liquid chromatography system.
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公开(公告)号:US11455797B2
公开(公告)日:2022-09-27
申请号:US17056484
申请日:2019-05-21
Applicant: Cytiva Sweden AB
Inventor: Petra Bangtsson , Johan Arthursson , Key Hyckenberg , Lotta Hedkvist
Abstract: The present invention relates to a method of automated configuration in a bioprocess system (10) and to verify a process defined by a flow path representation. The method comprises the steps of: —capturing one image of the bioprocess system (10) comprising tubing (50) for the fluid communication between units of the bioprocess system (10); —analyzing the captured image to identify the tubing (50) connecting units of the bioprocess system (10); —producing a processed representation from the captured image wherein at least a part of the tubing (50) is identified; and —comparing the processed representation with the flow path representation to verify their functional concordance.
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公开(公告)号:US20220163493A1
公开(公告)日:2022-05-26
申请号:US17602701
申请日:2020-04-16
Applicant: CYTIVA SWEDEN AB
Inventor: Jens Widehammar , Key Hyckenberg , Orjan Grelsson , Lars Mattsson , Kjell Karlsson
IPC: G01N30/86
Abstract: Disclosed is a chromatography system arranged to perform automated chromatography column efficiency testing for a specific column to determine efficiency parameters such as h and As and optionally to further provide guidance to the user with respect to column efficiency, the system having a controller arranged to automatically access data to enable the calculation of a column compression plate height, said data being derived from at least stored parameters of the specific column and the resin to be used in that column, thereby to calculate the efficiency of the column.
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