公开(公告)号：US20240123006A1

公开(公告)日：2024-04-18

申请号：US18546238

申请日：2022-02-15

Applicant: DSM IP ASSETS B.V.

Inventor： Joshua CLAYPOOL ,  Aaron COWIESON ,  Kevin FREEMAN ,  Ghislain SCHYNS

IPC: A61K36/06 ,  A23K10/30 ,  A23K20/158 ,  A23K20/163 ,  A23K50/75 ,  A61K31/05 ,  A61K31/4525 ,  A61P1/14

CPC classification number: A61K36/06 ,  A23K10/30 ,  A23K20/158 ,  A23K20/163 ,  A23K50/75 ,  A61K31/05 ,  A61K31/4525 ,  A61P1/14

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome improve the health and welfare of the animal. The present disclosure further relates to methods of modulating level of secondary metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level of tryptophan metabolism derivates.

公开(公告)号：US20240075059A1

公开(公告)日：2024-03-07

申请号：US18261762

申请日：2022-01-19

Applicant: DSM IP Assets B.V.

Inventor： Joshua Thomas CLAYPOOL ,  Ghislain SCHYNS ,  Carrie Louise WALK

IPC: A61K33/04 ,  A23K20/105 ,  A23K20/174 ,  A23K20/20 ,  A23K50/75 ,  A61K9/00 ,  A61K31/355 ,  A61P31/04

CPC classification number: A61K33/04 ,  A23K20/105 ,  A23K20/174 ,  A23K20/30 ,  A23K50/75 ,  A61K9/0056 ,  A61K31/355 ,  A61P31/04

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level said metabolites.

公开(公告)号：US20230405091A1

公开(公告)日：2023-12-21

申请号：US18248616

申请日：2021-10-15

Applicant: DSM IP ASSETS B.V. ,  NOVOZYMES A/S

Inventor： Joshua CLAYPOOL ,  Ghislain SCHYNS

IPC: A61K38/44 ,  A23K20/189 ,  A23K20/147 ,  A23K50/30 ,  A23K50/75

CPC classification number: A61K38/446 ,  C12Y115/01001 ,  A23K20/189 ,  A23K20/147 ,  A23K50/30 ,  A23K50/75

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating metabolites present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level said metabolites.

公开(公告)号：US20230368914A1

公开(公告)日：2023-11-16

申请号：US18022361

申请日：2021-08-24

Applicant: DSM IP ASSETS B.V.

Inventor： Kevin FREEMAN ,  Joshua CLAYPOOL ,  Ghislain SCHYNS ,  Riccardo SFRISO

IPC: G16H50/20 ,  G16H50/30 ,  G16H20/60 ,  A61B5/00

CPC classification number: G16H50/20 ,  G16H50/30 ,  G16H20/60 ,  A61B5/4866

Abstract: In some aspects, the disclosure is directed to methods and systems for identifying a set of predictor metabolites which are predictive of a state of an animal subject. For that purpose, a plurality of data sets of respective ones of a plurality of animal subjects may be obtained, wherein each of the plurality of data sets comprises measurement data comprising an indication of a concentration of each of a plurality of metabolites in a sample of a microbiome of a respective animal subject. A label may be provided at least in part characterizing the state of the animal subject. A feature selection process may be applied to the plurality of data sets to select and thereby identify a subset of the plurality of metabolites of which subset the concentrations are a statistically significant predictor of the state according to the label.

公开(公告)号：US20210393658A1

公开(公告)日：2021-12-23

申请号：US17292132

申请日：2019-11-08

Applicant: DSM IP Assets B.V. ,  Midori USA, Inc.

Inventor： Stephane DUVAL ,  John Michael GEREMIA ,  Lisa Ann LAPRADE ,  April Waguespack LEVY ,  Estefania PEREZ CALVO ,  Ghislain SCHYNS ,  Viviane VERLHAC ,  Joshua CLAYPOOL

IPC: A61K31/702 ,  A23K20/163 ,  A23K50/75 ,  A23K50/30

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating the microbial species present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level or function of microbial species.