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11.发明授权Modulation of KSP kinesin activity with heterocyclic-fused pyrimidinone derivatives 失效用杂环稠合嘧啶酮衍生物调节KSP驱动蛋白活性公开(公告)号：US07332498B2
公开(公告)日：2008-02-19
申请号：US11284806
申请日：2005-11-23
IPC分类号： A61K31/519 , A61K31/5025 , C07D471/04 , C07D487/04 , C07D498/04 , C07D211/78 , C07D211/82 , C07D211/70 , C07D211/90 , C07D211/72 , C07D211/84 , C07D213/84 , C07D213/72 , C07D213/78 , C07D213/46 , C07D213/56
CPC分类号： C07D471/04 , C07D475/02 , C07D487/04
摘要： A method of modulating KSP kinesin activity in vitro comprising contacting KSP kinesin with at least one chemical entity chosen from compounds represented by Formula I: and pharmaceutically acceptable salts thereof, where the variables are as defined further herein.
摘要翻译： 一种在体外调节KSP驱动蛋白活性的方法，包括使KSP驱动蛋白与至少一种选自式I表示的化合物的化学实体及其药学上可接受的盐接触，其中变量如本文进一步定义。
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公开(公告)号：US20100234386A1
公开(公告)日：2010-09-16
申请号：US12599544
申请日：2008-05-08
申请人： Amita Chaudhari , Dashyant Dhanak , Carla Ann Donatelli , Thomas H. Faitg , Yanhong Feng , Steven David Knight , Cynthia A. Parrish , Jeffrey M. Ralph , Martha A. Sarpong , Domingos J. Silva
发明人： Amita Chaudhari , Dashyant Dhanak , Carla Ann Donatelli , Thomas H. Faitg , Yanhong Feng , Steven David Knight , Cynthia A. Parrish , Jeffrey M. Ralph , Martha A. Sarpong , Domingos J. Silva
IPC分类号： A61K31/498 , C07D401/02 , A61P29/00 , A61P9/00 , A61P25/00 , A61P11/06 , A61P13/12 , A61P35/00 , A61P15/00
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/14
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
摘要翻译： 发明的是使用喹喔啉衍生物抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用喹喔啉衍生物的移植排斥和肺部损伤。
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公开(公告)号：US07629477B2
公开(公告)日：2009-12-08
申请号：US12142621
申请日：2008-06-19
申请人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
发明人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC分类号： C07D311/22
CPC分类号： C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：US20090082349A1
公开(公告)日：2009-03-26
申请号：US12281187
申请日：2007-03-02
IPC分类号： A61K31/5377 , A61K31/517 , A61K31/502 , A61P37/00 , A61P29/00 , A61P9/00 , A61P25/00 , A61P35/00
CPC分类号： A61K31/5377
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
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公开(公告)号：US20090048252A1
公开(公告)日：2009-02-19
申请号：US12281181
申请日：2007-03-02
IPC分类号： A61K31/427 , A61K31/5377 , A61K31/496 , A61K31/454
CPC分类号： A61K31/5377
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
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公开(公告)号：US20090023742A1
公开(公告)日：2009-01-22
申请号：US12281179
申请日：2007-03-02
IPC分类号： A61K31/498 , A61K31/426 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/496 , A61P29/00 , A61P25/00 , A61P11/06 , A61P19/02 , A61P13/12 , A61P35/00 , A61P9/00 , A61P37/02 , A61K31/437 , A61K31/454 , A61K31/428 , A61K31/4709
CPC分类号： A61K31/496
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
摘要翻译： 发明了使用取代的噻唑啉酮抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用取代的噻唑啉酮的移植物排斥和肺损伤。
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公开(公告)号：US07166595B2
公开(公告)日：2007-01-23
申请号：US10429195
申请日：2003-05-02
申请人： Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
发明人： Han-Jie Zhou , David J. Morgans, Jr. , Gustave Bergnes , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Nicholas D. Adams
IPC分类号： C07D239/36 , A61K31/513 , A61K31/517 , C07D239/70
CPC分类号： C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：US08119678B2
公开(公告)日：2012-02-21
申请号：US13075076
申请日：2011-03-29
申请人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
发明人： Andrew McDonald , Gustave Bergnes , Bainian Feng , David J. Morgans, Jr. , Steven David Knight , Kenneth A. Newlander , Dashyant Dhanak , Christopher A. Brook
IPC分类号： A61K31/4164
CPC分类号： C07D405/06 , C07D311/22 , C07D311/36 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：US20090203732A1
公开(公告)日：2009-08-13
申请号：US12281188
申请日：2007-03-02
IPC分类号： A61K31/437 , A61P35/00 , A61P9/00 , A61P25/28 , A61P11/06 , A61P17/06 , A61P19/02 , A61P29/00 , A61P1/00
CPC分类号： A61K31/4745
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
摘要翻译： 发明了使用取代的噻唑啉酮抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用取代的噻唑啉酮的移植物排斥和肺损伤。
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公开(公告)号：US20090170882A1
公开(公告)日：2009-07-02
申请号：US11631138
申请日：2005-06-30
IPC分类号： A61K31/403 , C07D209/88 , A61K31/519 , A61P37/00 , A61P29/00 , A61P31/10 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04 , C07D209/86 , C07D209/88
摘要： Compounds, compositions and methods relating to kinesin inhibition are described herein.
摘要翻译： 本文描述了与驱动蛋白抑制有关的化合物，组合物和方法。
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