公开(公告)号：US5384265A

公开(公告)日：1995-01-24

申请号：US37981

申请日：1993-03-26

Applicant: David A. Kidwell ,  Susan M. Conyers

Inventor： David A. Kidwell ,  Susan M. Conyers

IPC: G01N33/553 ,  G01N33/58

CPC classification number: G01N33/587 ,  G01N33/553 ,  Y10S436/805

Abstract: Catalytic colloidal metal particles bound to a biomolecule such as an antibody, avidin, or streptavidin are useful for detecting the presence of the biomolecule in an assay such as an immunoassay.

Abstract translation: 与生物分子如抗体，抗生物素蛋白或链霉亲和素结合的催化胶体金属颗粒可用于在诸如免疫测定的测定中检测生物分子的存在。

公开(公告)号：US5372930A

公开(公告)日：1994-12-13

申请号：US945057

申请日：1992-09-16

Applicant: Richard J. Colton ,  David A. Kidwell

Inventor： Richard J. Colton ,  David A. Kidwell

IPC: G01Q60/42 ,  G01N33/543 ,  G01Q70/14

CPC classification number: G01Q60/42 ,  B82Y35/00 ,  G01N33/54373 ,  Y10S977/877

Abstract: A sensor for ultra-low concentration chemical recognition comprises a force transducer, a tip coupled to this force transducer, and a substrate positioned for force interaction with the force transducer tip, where the substrate and tip are chemically modified with antigens, antibodies, nucleic acids, or chelating agents so that there is a specific force interaction between the tip and the substrate in the presence of the target species, and a measurably different force interaction in the absence of the target species.

Abstract translation: 用于超低浓度化学识别的传感器包括力传感器，连接到该力传感器的尖端，以及定位成与力传感器尖端的力相互作用的衬底，其中衬底和尖端被抗原，抗体，核酸 或螯合剂，使得在存在目标物种的情况下在尖端和基底之间存在特定的力相互作用，以及在不存在靶物种的情况下可测量地不同的力相互作用。

公开(公告)号：US5332659A

公开(公告)日：1994-07-26

申请号：US4009

申请日：1993-01-15

Applicant: David A. Kidwell

Inventor： David A. Kidwell

IPC: C12Q1/68 ,  G01N33/542 ,  G01N33/94 ,  G01N21/64

CPC classification number: C12Q1/6818 ,  G01N33/542 ,  G01N33/946

Abstract: A target polynucleic acid strand may be detected within a sample. A sensing strand of complementary polynucleic acid is labelled, at at least two internucleotide phosphate groups, with labels which vary their electronically interaction with each other, and thus their emission or absorption spectra, depending upon whether the sensing strand is bound to target polynucleic acid in the sample.

Abstract translation: 可以在样品内检测到目标多核酸链。 互补多核酸的感测链在至少两个核苷酸间磷酸酯基团处被标记，其标记可以改变它们彼此的电子相互作用，并且因此其发射或吸收光谱，这取决于感测链是否与靶多核酸结合 例子。

公开(公告)号：US09192918B2

公开(公告)日：2015-11-24

申请号：US13962024

申请日：2013-08-08

Applicant: David A. Kidwell

Inventor： David A. Kidwell

IPC: B01J23/58 ,  B01J23/44 ,  B01J21/04 ,  B01J23/42 ,  B01J23/63 ,  B01J29/04 ,  B01J35/10 ,  B01J37/02

CPC classification number: B01J23/58 ,  B01J21/04 ,  B01J23/42 ,  B01J23/44 ,  B01J23/63 ,  B01J29/04 ,  B01J35/1019 ,  B01J37/0201 ,  B01J37/0213

Abstract: Disclosed herein is a method for producing excess enthalpy by (a) either dispersing atomic metal ions or clusters on a support and reacting the metal ions with a chelating ligand or dispersing chelated atomic metal ions on a support and (b) pressurizing with hydrogen or deuterium to reduce the metal ion to a metal atom resulting in the growth of dispersed metal particles less than 2 nm in diameter on the support. During the particle growth, there is a growth period during which a critical particle size is reached and excess enthalpy is produced. The growth period is typically several days long.

Abstract translation: 本文公开了一种通过（a）将原子金属离子或簇分散在载体上并使金属离子与螯合配体或将螯合的原子金属离子分散在载体上并且（b）用氢或氘加压的方法来产生过量的焓 以将金属离子还原成金属原子，导致在载体上直径小于2nm的分散金属颗粒的生长。 在颗粒生长期间，存在达到临界粒径并产生过量焓的生长期。 生长期通常为几天。

公开(公告)号：US09182365B2

公开(公告)日：2015-11-10

申请号：US13921195

申请日：2013-06-18

Applicant: David A. Kidwell

Inventor： David A. Kidwell

IPC: B01F3/06 ,  G01N25/48 ,  B01J21/04 ,  B01J23/42 ,  B01J23/44 ,  B01J23/63 ,  B01J29/04

CPC classification number: G01N25/48 ,  B01J21/04 ,  B01J23/42 ,  B01J23/44 ,  B01J23/63 ,  B01J29/04

Abstract: A method for producing excess enthalpy by impregnating metallic precursors on an oxide support that reduces sintering and particle growth; drying the impregnated support at a temperature where the particle growth is minimal; reducing the metallic precursors at a second temperature where the particle growth results in supported metallic particles 2 nm or less in size; and pressurizing the supported metallic particles in the presence of deuterium. The metal particles may comprise palladium, platinum, mixtures thereof, or mixtures of palladium and/or platinum with other elements. Also disclosed is a method for measuring excess enthalpy by placing a test material in a pressure vessel; heating the pressure vessel; evacuating the pressure vessel; introducing deuterium, hydrogen, or both into the pressure vessel; measuring the enthalpy generated during pressurization; again evacuating the pressure vessel; and measuring the enthalpy used during depressurization.

Abstract translation: 通过将金属前体浸渍在减少烧结和颗粒生长的氧化物载体上来产生过量焓的方法; 在颗粒生长最小的温度下干燥浸渍的载体; 在第二温度下还原金属前体，其中颗粒生长导致尺寸为2nm或更小的负载金属颗粒; 并在氘存在下对负载的金属颗粒加压。 金属颗粒可以包括钯，铂，其混合物，或钯和/或铂与其它元素的混合物。 还公开了一种通过将测试材料放置在压力容器中来测量过量焓的方法; 加热压力容器; 排空压力容器; 将氘，氢或二者引入压力容器中; 测量加压过程中产生的焓; 再次抽空压力容器; 并测量在减压期间使用的焓。

公开(公告)号：US20130316897A1

公开(公告)日：2013-11-28

申请号：US13962024

申请日：2013-08-08

Applicant: David A. Kidwell

Inventor： David A. Kidwell

IPC: B01J23/58

CPC classification number: B01J23/58 ,  B01J21/04 ,  B01J23/42 ,  B01J23/44 ,  B01J23/63 ,  B01J29/04 ,  B01J35/1019 ,  B01J37/0201 ,  B01J37/0213

Abstract: Disclosed herein is a method for producing excess enthalpy by (a) either dispersing atomic metal ions or clusters on a support and reacting the metal ions with a chelating ligand or dispersing chelated atomic metal ions on a support and (b) pressurizing with hydrogen or deuterium to reduce the metal ion to a metal atom resulting in the growth of dispersed metal particles less than 2 nm in diameter on the support. During the particle growth, there is a growth period during which a critical particle size is reached and excess enthalpy is produced. The growth period is typically several days long

Abstract translation: 本文公开了一种通过（a）将原子金属离子或簇分散在载体上并使金属离子与螯合配体或将螯合的原子金属离子分散在载体上并且（b）用氢或氘加压的方法来产生过量的焓 以将金属离子还原成金属原子，导致在载体上直径小于2nm的分散金属颗粒的生长。 在颗粒生长期间，存在达到临界粒径并产生过量焓的生长期。 生长期通常为几天

公开(公告)号：US20130280128A1

公开(公告)日：2013-10-24

申请号：US13921195

申请日：2013-06-18

Applicant: David A. Kidwell

Inventor： David A. Kidwell

IPC: G01N25/48

CPC classification number: G01N25/48 ,  B01J21/04 ,  B01J23/42 ,  B01J23/44 ,  B01J23/63 ,  B01J29/04

Abstract: A method for producing excess enthalpy by impregnating metallic precursors on an oxide support that reduces sintering and particle growth; drying the impregnated support at a temperature where the particle growth is minimal; reducing the metallic precursors at a second temperature where the particle growth results in supported metallic particles 2 nm or less in size; and pressurizing the supported metallic particles in the presence of deuterium. The metal particles may comprise palladium, platinum, mixtures thereof, or mixtures of palladium and/or platinum with other elements. Also disclosed is a method for measuring excess enthalpy by placing a test material in a pressure vessel; heating the pressure vessel; evacuating the pressure vessel; introducing deuterium, hydrogen, or both into the pressure vessel; measuring the enthalpy generated during pressurization; again evacuating the pressure vessel; and measuring the enthalpy used during depressurization.

Abstract translation: 通过将金属前体浸渍在减少烧结和颗粒生长的氧化物载体上来产生过量焓的方法; 在颗粒生长最小的温度下干燥浸渍的载体; 在第二温度下还原金属前体，其中颗粒生长导致尺寸为2nm或更小的负载金属颗粒; 并在氘存在下对负载的金属颗粒加压。 金属颗粒可以包括钯，铂，其混合物，或钯和/或铂与其它元素的混合物。 还公开了一种通过将测试材料放置在压力容器中来测量过量焓的方法; 加热压力容器; 排空压力容器; 将氘，氢或二者引入压力容器中; 测量加压过程中产生的焓; 再次抽空压力容器; 并测量在减压期间使用的焓。

公开(公告)号：US20120144956A1

公开(公告)日：2012-06-14

申请号：US13323287

申请日：2011-12-12

Applicant: David A. Kidwell ,  Albert Epshteyn

Inventor： David A. Kidwell ,  Albert Epshteyn

IPC: B22F9/16 ,  C07K7/06 ,  C07C229/06 ,  B82Y40/00

CPC classification number: B22F9/24 ,  B22F2999/00 ,  B82Y30/00 ,  B82Y40/00 ,  B22F1/0018 ,  B22F2301/25

Abstract: A metron refers to a molecule which contains a pre-defined number of high affinity binding sites for metal ions. Metrons may be used to prepare homogenous populations of nanoparticles each composed of a same, specific number of atoms, wherein each particle has the same size ranging from 2 atoms to about ten nanometers.

Abstract translation: 指甲是指含有预定数量的金属离子的高亲合力结合位点的分子。 Metron可以用于制备均匀的纳米粒子群，每个纳米粒子由相同的特定数量的原子组成，其中每个粒子具有从2个原子到约10纳米的相同的大小。

公开(公告)号：US07618523B2

公开(公告)日：2009-11-17

申请号：US10833636

申请日：2004-04-26

Applicant: David A. Kidwell

Inventor： David A. Kidwell

IPC: G01N27/30

CPC classification number: G01N33/48714 ,  G01N27/3335

Abstract: A hand-held portable drug monitoring system to detect and quantitate cocaine and other organic drugs in saliva, sweat, and surface wipes by using an ion selective electrode or an array of ion selective electrodes. The ion selective electrode has a cast membrane reference electrode and a sensing electrode with a hydrophobic polymer, a plasticizer, and an ionophore selective for the organic drug to be tested. The ion selective electrode can be connected to a converter that coverts a voltage reading from the ion selective electrode to a quantitative drug concentration level. Also disclosed is the related method of using an ion selective electrode to detect an organic drug in saliva, sweat, and surface wipes, the method of testing electrical contact in an ion selective electrode, and the method of making a cast membrane reference electrode.

Abstract translation: 手提便携式药物监测系统，通过使用离子选择性电极或离子选择性电极阵列来检测和定量唾液，汗液和表面擦拭物中的可卡因和其他有机药物。 离子选择电极具有铸膜参比电极和具有疏水性聚合物，增塑剂和对待测有机药物选择性的离子载体的感测电极。 离子选择电极可以连接到转换器，其将从离子选择性电极读取的电压覆盖到定量药物浓度水平。 还公开了使用离子选择电极检测唾液，汗液和表面擦拭物中的有机药物的相关方法，测试离子选择性电极中的电接触的方法以及制备流延膜参比电极的方法。

公开(公告)号：US20090173629A1

公开(公告)日：2009-07-09

申请号：US12402271

申请日：2009-03-11

Applicant: David A. Kidwell

Inventor： David A. Kidwell

IPC: G01N27/26

CPC classification number: G01N33/48714 ,  G01N27/3335

Abstract: A miniature, lightweight, inexpensive, environmental monitoring system containing a number of sensors that can simultaneously and continuously monitor fluorescence, absorbance, conductivity, temperature, and several ions. Sensors that monitor similar parameters can cross-check data to increase the likelihood that a problem with the water will be discovered.

Abstract translation: 一个微型，轻便，便宜的环境监测系统，其中包含许多可同时连续监测荧光，吸光度，电导率，温度和几种离子的传感器。 监测类似参数的传感器可以交叉检查数据，以增加发现水的问题的可能性。