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    Powders
    11.
    发明授权
    Powders 失效
    粉末

    公开(公告)号：US06989155B1

    公开(公告)日：2006-01-24

    申请号：US09857392

    申请日：1999-12-09

    Applicant: David Ganderton ,  David Alexander Vodden Morton ,  Paul Lucas

    Inventor： David Ganderton ,  David Alexander Vodden Morton ,  Paul Lucas

    IPC: A61K9/14 ,  A61K9/50 ,  B32B15/02

    CPC classification number: A61K9/0075 ,  A61K9/145 ,  Y10T428/2982

    Abstract: Particles of an amino acid such as leucine may be formed from an amino acid vapor, for example by aerosol condensation, or by spray drying. The amino acid particles have a bulk density of not more than 0.1 gcm−3 or have a mass median aerodynamic diameter of not more than 10 μm or are in the form of flakes having a thickness of not more than 100 μm. The inclusion of the particles of amino acid in powder for use in dry powder inhalers has been found to improve the respirable fraction of the active material in the powder.

    Abstract translation: 氨基酸如亮氨酸的颗粒可以由氨基酸蒸气形成，例如通过气溶胶冷凝或通过喷雾干燥形成。 氨基酸颗粒的堆积密度不超过0.1g / cm3，或质量中值空气动力学直径不大于10um，或者为薄片形式，其厚度不大于 100个妈妈 发现将氨基酸颗粒包含在干粉吸入器中的粉末中可以改善粉末中活性物质的可呼吸分数。

    Mouthpiece for a particulate inhaler
    12.
    发明授权
    Mouthpiece for a particulate inhaler 失效
    颗粒吸入器的口腔

    公开(公告)号：US06810875B2

    公开(公告)日：2004-11-02

    申请号：US10283418

    申请日：2002-11-18

    Applicant: John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Iain Grierson McDerment

    Inventor： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Iain Grierson McDerment

    IPC: B65D8306

    CPC classification number: A61M15/0065 ,  A61M11/002 ,  A61M15/0021 ,  A61M2202/064 ,  A61M2206/14

    Abstract: Mouthpieces for particulate inhalers typically have either stationary particle deflectors or rotatable devices for changing the flow of particulate material through the mouthpiece. However, these mouthpieces do not prevent the build up of particulate drug on the walls of the mouthpiece. Thus, there is provided a mouthpiece (10) for use in an inhaler for particulate medicament, the mouthpiece having an inlet (12) and an outlet (13) for particulate medicament, a helical member (15) disposed between the inlet and the outlet for, in use, imparting a rotational movement to an air flow which is drawn through the mouthpiece and in which medicament is entrained, wherein the helical member (15) is, in use, axially movable between a first position and a second position such that it restricts the build up of medicament on the inside of the mouthpiece (10).

    Pharmaceutical formulations for dry powder inhalers
    18.
    发明授权
    Pharmaceutical formulations for dry powder inhalers 有权
    干粉吸入器的药物制剂

    公开(公告)号：US07541022B2

    公开(公告)日：2009-06-02

    申请号：US10257886

    申请日：2001-04-17

    Applicant: John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzno Ferrarini

    Inventor： John Nicholas Staniforth ,  David Alexander Vodden Morton ,  Rajbir Gill ,  Gaetano Brambilla ,  Rossella Musa ,  Lorenzno Ferrarini

    IPC: A61K9/14 ,  A61K9/16

    CPC classification number: A61K9/16 ,  A61K9/0075 ,  A61K9/145 ,  A61K9/1682 ,  A61K31/167 ,  A61K31/58

    Abstract: A powder for use in a dry powder inhaler comprises: i) a fraction n of fine particle size constituted by a mixture of physiologically acceptable excipient and an additive; ii) a fraction of coarse particles; and iii) at least one active ingredient. The powder is suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from pulmonary diseases such as asthma. In particular, the invention provides a formulation to be administered as dry powder for inhalation which is freely flowable, can be produced in a simple way, is physically and chemically stable and capable of delivering accurate doses and/or high fine particle fraction of low strength active ingredients by using a high- or medium resistance device.

    Abstract translation: 用于干粉吸入器的粉末包括：i）由生理上可接受的赋形剂和添加剂的混合物构成的细粒度的分数n; ii）一部分粗颗粒; 和iii）至少一种活性成分。 该粉末适用于将有效成分有效递送至患有肺部疾病如哮喘的患者的低呼吸道。 特别地，本发明提供了作为可自由流动的用于吸入的干燥粉末施用的制剂，可以以简单的方式产生，物理和化学稳定并且能够输送精确剂量和/或低强度的高细颗粒级分 使用高或中等阻力装置的活性成分。

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